Pharmacology and functions of metabotropic glutamate receptors. Conn PJ, Pin JP (1997) Annu Rev Pharmacol Toxicol 37: 205-37 Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A. Zheng F, Erreger K, Low CM, Banke T, Lee CJ, Conn PJ, Traynelis SF (2001) Nat Neurosci 4: 894-901 Peripheral group I metabotropic glutamate receptors modulate nociception in mice. Bhave G, Karim F, Carlton SM, Gereau RW (2001) Nat Neurosci 4: 417-23 Pet-1 is required across different stages of life to regulate serotonergic function. Liu C, Maejima T, Wyler SC, Casadesus G, Herlitze S, Deneris ES (2010) Nat Neurosci 13: 1190-8 Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice. Ade KK, Wan Y, Hamann HC, O'Hare JK, Guo W, Quian A, Kumar S, Bhagat S, Rodriguiz RM, Wetsel WC, Conn PJ, Dzirasa K, Huber KM, Calakos N (2016) Biol Psychiatry 80: 522-33 A shift in the role of glutamatergic signaling in the nucleus accumbens core with the development of an addicted phenotype. Doyle SE, Ramôa C, Garber G, Newman J, Toor Z, Lynch WJ (2014) Biol Psychiatry 76: 810-5 Alcohol inhibits NR2B-containing NMDA receptors in the ventral bed nucleus of the stria terminalis. Kash TL, Matthews RT, Winder DG (2008) Neuropsychopharmacology 33: 1379-90 Group II and III metabotropic glutamate receptors suppress excitatory synaptic transmission in the dorsolateral bed nucleus of the stria terminalis. Grueter BA, Winder DG (2005) Neuropsychopharmacology 30: 1302-11 Ketamine and MAG Lipase Inhibitor-Dependent Reversal of Evolving Depressive-Like Behavior During Forced Abstinence From Alcohol Drinking. Holleran KM, Wilson HH, Fetterly TL, Bluett RJ, Centanni SW, Gilfarb RA, Rocco LE, Patel S, Winder DG (2016) Neuropsychopharmacology 41: 2062-71 Metabotropic glutamate receptor 5-induced phosphorylation of extracellular signal-regulated kinase in astrocytes depends on transactivation of the epidermal growth factor receptor. Peavy RD, Chang MS, Sanders-Bush E, Conn PJ (2001) J Neurosci 21: 9619-28 Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus. Klar R, Walker AG, Ghose D, Grueter BA, Engers DW, Hopkins CR, Lindsley CW, Xiang Z, Conn PJ, Niswender CM (2015) J Neurosci 35: 7600-15 Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus. Poisik OV, Mannaioni G, Traynelis S, Smith Y, Conn PJ (2003) J Neurosci 23: 122-30 Intracellular modulation of NMDA receptor function by antipsychotic drugs. Leveque JC, Macías W, Rajadhyaksha A, Carlson RR, Barczak A, Kang S, Li XM, Coyle JT, Huganir RL, Heckers S, Konradi C (2000) J Neurosci 20: 4011-20 In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression. Grueter BA, McElligott ZA, Robison AJ, Mathews GC, Winder DG (2008) J Neurosci 28: 9261-70 Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus. Awad H, Hubert GW, Smith Y, Levey AI, Conn PJ (2000) J Neurosci 20: 7871-9 Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function. Mannaioni G, Marino MJ, Valenti O, Traynelis SF, Conn PJ (2001) J Neurosci 21: 5925-34 Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS. Yin S, Noetzel MJ, Johnson KA, Zamorano R, Jalan-Sakrikar N, Gregory KJ, Conn PJ, Niswender CM (2014) J Neurosci 34: 79-94 Novel blockade of protein kinase A-mediated phosphorylation of AMPA receptors. Vanhoose AM, Clements JM, Winder DG (2006) J Neurosci 26: 1138-45 Activation of group I metabotropic glutamate receptors produces a direct excitation and disinhibition of GABAergic projection neurons in the substantia nigra pars reticulata. Marino MJ, Wittmann M, Bradley SR, Hubert GW, Smith Y, Conn PJ (2001) J Neurosci 21: 7001-12 Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex. Zeng LH, Ouyang Y, Gazit V, Cirrito JR, Jansen LA, Ess KC, Yamada KA, Wozniak DF, Holtzman DM, Gutmann DH, Wong M (2007) Neurobiol Dis 28: 184-96 Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors. Marino MJ, Conn PJ (2006) Curr Opin Pharmacol 6: 98-102 Gabapentin inhibits catecholamine release from adrenal chromaffin cells. Todd RD, McDavid SM, Brindley RL, Jewell ML, Currie KP (2012) Anesthesiology 116: 1013-24 Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7. Niswender CM, Johnson KA, Miller NR, Ayala JE, Luo Q, Williams R, Saleh S, Orton D, Weaver CD, Conn PJ (2010) Mol Pharmacol 77: 459-68 A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. O'Brien JA, Lemaire W, Chen TB, Chang RS, Jacobson MA, Ha SN, Lindsley CW, Schaffhauser HJ, Sur C, Pettibone DJ, Conn PJ, Williams DL (2003) Mol Pharmacol 64: 731-40 Difference in mGluR5 interaction between positive allosteric modulators from two structural classes. Williams DL, O'Brien JA, Lemaire W, Chen TB, Chang RS, Jacobson MA, Ha SN, Wisnoski DD, Lindsley CW, Sur C, Duggan ME, Pettibone DJ, Conn PJ (2003) Ann N Y Acad Sci 1003: 481-4 Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus. Poisik O, Raju DV, Verreault M, Rodriguez A, Abeniyi OA, Conn PJ, Smith Y (2005) Neuropharmacology 49 Suppl 1: 57-69 Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. D'Amore V, Santolini I, van Rijn CM, Biagioni F, Molinaro G, Prete A, Conn PJ, Lindsley CW, Zhou Y, Vinson PN, Rodriguez AL, Jones CK, Stauffer SR, Nicoletti F, van Luijtelaar G, Ngomba RT (2013) Neuropharmacology 66: 330-8 Modulation of pyramidal cell output in the medial prefrontal cortex by mGluR5 interacting with CB1. Kiritoshi T, Sun H, Ren W, Stauffer SR, Lindsley CW, Conn PJ, Neugebauer V (2013) Neuropharmacology 66: 170-8 Functional selectivity induced by mGlu₄ receptor positive allosteric modulation and concomitant activation of Gq coupled receptors. Yin S, Zamorano R, Conn PJ, Niswender CM (2013) Neuropharmacology 66: 122-32 Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells. Sheffler DJ, Conn PJ (2008) Neuropharmacology 55: 419-27 Metabotropic glutamate receptors mGluR4 and mGluR8 regulate transmission in the lateral olfactory tract-piriform cortex synapse. Jones PJ, Xiang Z, Conn PJ (2008) Neuropharmacology 55: 440-6 Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated. Ayala JE, Niswender CM, Luo Q, Banko JL, Conn PJ (2008) Neuropharmacology 54: 804-14 Activation of groups I or III metabotropic glutamate receptors inhibits excitatory transmission in the rat subthalamic nucleus. Awad-Granko H, Conn PJ (2001) Neuropharmacology 41: 32-41 Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery. Sengmany K, Singh J, Stewart GD, Conn PJ, Christopoulos A, Gregory KJ (2017) Neuropharmacology 115: 60-72 M muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons. Lv X, Dickerson JW, Rook JM, Lindsley CW, Conn PJ, Xiang Z (2017) Neuropharmacology 118: 209-222 Regulation of stargazin synaptic trafficking by C-terminal PDZ ligand phosphorylation in bidirectional synaptic plasticity. Stein EL, Chetkovich DM (2010) J Neurochem 113: 42-53 Phosphorylation of mitogen-activated protein kinase in cultured rat cortical glia by stimulation of metabotropic glutamate receptors. Peavy RD, Conn PJ (1998) J Neurochem 71: 603-12 Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling. Li J, Guo Y, Schroeder FA, Youngs RM, Schmidt TW, Ferris C, Konradi C, Akbarian S (2004) J Neurochem 90: 1117-31 Activation of metabotropic glutamate receptors in the hippocampus increases cyclic AMP accumulation. Winder DG, Conn PJ (1992) J Neurochem 59: 375-8 Inhibition of glutamate-induced mitochondrial depolarization by tamoxifen in cultured neurons. Hoyt KR, McLaughlin BA, Higgins DS, Reynolds IJ (2000) J Pharmacol Exp Ther 293: 480-6
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