Diclofenac delays micropore closure following microneedle treatment in human subjects. Brogden NK, Milewski M, Ghosh P, Hardi L, Crofford LJ, Stinchcomb AL (2012) J Control Release 163: 220-9 Diclofenac enables unprecedented week-long microneedle-enhanced delivery of a skin impermeable medication in humans. Brogden NK, Banks SL, Crofford LJ, Stinchcomb AL (2013) Pharm Res 30: 1947-55 A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385. Rowlinson SW, Kiefer JR, Prusakiewicz JJ, Pawlitz JL, Kozak KR, Kalgutkar AS, Stallings WC, Kurumbail RG, Marnett LJ (2003) J Biol Chem 278: 45763-9 Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib. Blobaum AL, Marnett LJ (2007) J Biol Chem 282: 16379-90 Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes. Yamazaki H, Inoue K, Chiba K, Ozawa N, Kawai T, Suzuki Y, Goldstein JA, Guengerich FP, Shimada T (1998) Biochem Pharmacol 56: 243-51 Exploring the molecular determinants of substrate-selective inhibition of cyclooxygenase-2 by lumiracoxib. Windsor MA, Valk PL, Xu S, Banerjee S, Marnett LJ (2013) Bioorg Med Chem Lett 23: 5860-4 Randomised controlled trial of the onset of analgesic efficacy of dexketoprofen and diclofenac in lower limb injury. Leman P, Kapadia Y, Herington J (2003) Emerg Med J 20: 511-3
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.