Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia. DeBaun MR, Gordon M, McKinstry RC, Noetzel MJ, White DA, Sarnaik SA, Meier ER, Howard TH, Majumdar S, Inusa BP, Telfer PT, Kirby-Allen M, McCavit TL, Kamdem A, Airewele G, Woods GM, Berman B, Panepinto JA, Fuh BR, Kwiatkowski JL, King AA, Fixler JM, Rhodes MM, Thompson AA, Heiny ME, Redding-Lallinger RC, Kirkham FJ, Dixon N, Gonzalez CE, Kalinyak KA, Quinn CT, Strouse JJ, Miller JP, Lehmann H, Kraut MA, Ball WS, Hirtz D, Casella JF (2014) N Engl J Med 371: 699-710 Transfusions for silent cerebral infarcts in sickle cell anemia. DeBaun MR, Casella JF (2014) N Engl J Med 371: 1841-2 The index case for the fungal meningitis outbreak in the United States. Pettit AC, Kropski JA, Castilho JL, Schmitz JE, Rauch CA, Mobley BC, Wang XJ, Spires SS, Pugh ME (2012) N Engl J Med 367: 2119-25 Elevation of IgE in children with sickle cell disease is associated with doctor diagnosis of asthma and increased morbidity. An P, Barron-Casella EA, Strunk RC, Hamilton RG, Casella JF, DeBaun MR (2011) J Allergy Clin Immunol 127: 1440-6 Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC (2019) Nat Commun 10: 187 Silent infarcts in sickle cell disease occur in the border zone region and are associated with low cerebral blood flow. Ford AL, Ragan DK, Fellah S, Binkley MM, Fields ME, Guilliams KP, An H, Jordan LC, McKinstry RC, Lee JM, DeBaun MR (2018) Blood 132: 1714-1723 Silent cerebral infarcts and cerebral aneurysms are prevalent in adults with sickle cell anemia. Kassim AA, Pruthi S, Day M, Rodeghier M, Gindville MC, Brodsky MA, DeBaun MR, Jordan LC (2016) Blood 127: 2038-40 Silent cerebral infarcts: a review on a prevalent and progressive cause of neurologic injury in sickle cell anemia. DeBaun MR, Armstrong FD, McKinstry RC, Ware RE, Vichinsky E, Kirkham FJ (2012) Blood 119: 4587-96 Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure. DeBaun MR, Sarnaik SA, Rodeghier MJ, Minniti CP, Howard TH, Iyer RV, Inusa B, Telfer PT, Kirby-Allen M, Quinn CT, Bernaudin F, Airewele G, Woods GM, Panepinto JA, Fuh B, Kwiatkowski JK, King AA, Rhodes MM, Thompson AA, Heiny ME, Redding-Lallinger RC, Kirkham FJ, Sabio H, Gonzalez CE, Saccente SL, Kalinyak KA, Strouse JJ, Fixler JM, Gordon MO, Miller JP, Noetzel MJ, Ichord RN, Casella JF (2012) Blood 119: 3684-90 Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease. Hulbert ML, McKinstry RC, Lacey JL, Moran CJ, Panepinto JA, Thompson AA, Sarnaik SA, Woods GM, Casella JF, Inusa B, Howard J, Kirkham FJ, Anie KA, Mullin JE, Ichord R, Noetzel M, Yan Y, Rodeghier M, Debaun MR (2011) Blood 117: 772-9 Reversible posterior leukoencephalopathy syndrome and silent cerebral infarcts are associated with severe acute chest syndrome in children with sickle cell disease. Henderson JN, Noetzel MJ, McKinstry RC, White DA, Armstrong M, DeBaun MR (2003) Blood 101: 415-9 Poor school and cognitive functioning with silent cerebral infarcts and sickle cell disease. Schatz J, Brown RT, Pascual JM, Hsu L, DeBaun MR (2001) Neurology 56: 1109-11 Silent infarct is a risk factor for infarct recurrence in adults with sickle cell anemia. Jordan LC, Kassim AA, Donahue MJ, Juttukonda MR, Pruthi S, Davis LT, Rodeghier M, Lee CA, Patel NJ, DeBaun MR (2018) Neurology 91: e781-e784 Cognitive screening examinations for silent cerebral infarcts in sickle cell disease. DeBaun MR, Schatz J, Siegel MJ, Koby M, Craft S, Resar L, Chu JY, Launius G, Dadash-Zadeh M, Lee RB, Noetzel M (1998) Neurology 50: 1678-82 Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia. McCullough L, Wu L, Haughey N, Liang X, Hand T, Wang Q, Breyer RM, Andreasson K (2004) J Neurosci 24: 257-68 Baroreflex failure in a patient with central nervous system lesions involving the nucleus tractus solitarii. Biaggioni I, Whetsell WO, Jobe J, Nadeau JH (1994) Hypertension 23: 491-5 Cerebral infarction in sickle cell disease: transcranial Doppler US versus neurologic examination. Siegel MJ, Luker GD, Glauser TA, DeBaun MR (1995) Radiology 197: 191-4 Intrinsic pathway of coagulation and arterial thrombosis. Gailani D, Renné T (2007) Arterioscler Thromb Vasc Biol 27: 2507-13 Oxidative stress and matrix metalloproteinase-9 in acute ischemic stroke: the Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) study. Kelly PJ, Morrow JD, Ning M, Koroshetz W, Lo EH, Terry E, Milne GL, Hubbard J, Lee H, Stevenson E, Lederer M, Furie KL (2008) Stroke 39: 100-4 Neuroimaging Advances in Pediatric Stroke. Donahue MJ, Dlamini N, Bhatia A, Jordan LC (2019) Stroke 50: 240-248 Participation of bone marrow-derived cells in long-term repair processes after experimental stroke. Beck H, Voswinckel R, Wagner S, Ziegelhoeffer T, Heil M, Helisch A, Schaper W, Acker T, Hatzopoulos AK, Plate KH (2003) J Cereb Blood Flow Metab 23: 709-17 Incidental findings on brain magnetic resonance imaging of children with sickle cell disease. Jordan LC, McKinstry RC, Kraut MA, Ball WS, Vendt BA, Casella JF, DeBaun MR, Strouse JJ, Silent Infarct Transfusion Trial Investigators (2010) Pediatrics 126: 53-61 Silent cerebral infarcts in sickle cell anemia: a risk factor analysis. The Cooperative Study of Sickle Cell Disease. Kinney TR, Sleeper LA, Wang WC, Zimmerman RA, Pegelow CH, Ohene-Frempong K, Wethers DL, Bello JA, Vichinsky EP, Moser FG, Gallagher DM, DeBaun MR, Platt OS, Miller ST (1999) Pediatrics 103: 640-5 Intracranial vasculopathy and infarct recurrence in children with sickle cell anaemia, silent cerebral infarcts and normal transcranial Doppler velocities. Choudhury NA, DeBaun MR, Ponisio MR, Jordan LC, Rodeghier M, Pruthi S, McKinstry RC (2018) Br J Haematol 183: 324-326 Magnetic resonance angiography-defined intracranial vasculopathy is associated with silent cerebral infarcts and glucose-6-phosphate dehydrogenase mutation in children with sickle cell anaemia. Thangarajh M, Yang G, Fuchs D, Ponisio MR, McKinstry RC, Jaju A, Noetzel MJ, Casella JF, Barron-Casella E, Hooper WC, Boulet SL, Bean CJ, Pyle ME, Payne AB, Driggers J, Trau HA, Vendt BA, Rodeghier M, DeBaun MR (2012) Br J Haematol 159: 352-9 Thrombospondin-1 and L-selectin are associated with silent cerebral infarct in children with sickle cell anaemia. Faulcon LM, Fu Z, Dulloor P, Barron-Casella E, Savage W, Jennings JM, Van Eyk JE, Debaun M, Casella JF, Everett A (2013) Br J Haematol 162: 421-4 Oxidized low-density lipoprotein is present in astrocytes surrounding cerebral infarcts and stimulates astrocyte interleukin-6 secretion. Shie FS, Neely MD, Maezawa I, Wu H, Olson SJ, Jürgens G, Montine KS, Montine TJ (2004) Am J Pathol 164: 1173-81 Headache and migraine in children with sickle cell disease are associated with lower hemoglobin and higher pain event rates but not silent cerebral infarction. Dowling MM, Noetzel MJ, Rodeghier MJ, Quinn CT, Hirtz DG, Ichord RN, Kwiatkowski JL, Roach ES, Kirkham FJ, Casella JF, DeBaun MR (2014) J Pediatr 164: 1175-1180.e1 Reply: To PMID 24529619. DeBaun MR, Dowling MM (2014) J Pediatr 165: 646 Silent cerebral infarction, income, and grade retention among students with sickle cell anemia. King AA, Rodeghier MJ, Panepinto JA, Strouse JJ, Casella JF, Quinn CT, Dowling MM, Sarnaik SA, Thompson AA, Woods GM, Minniti CP, Redding-Lallinger RC, Kirby-Allen M, Kirkham FJ, McKinstry R, Noetzel MJ, White DA, Kwiatkowski JK, Howard TH, Kalinyak KA, Inusa B, Rhodes MM, Heiny ME, Fuh B, Fixler JM, Gordon MO, DeBaun MR (2014) Am J Hematol 89: E188-92 Plasma glial fibrillary acidic protein levels in children with sickle cell disease. Savage WJ, Barron-Casella E, Fu Z, Dulloor P, Williams L, Crain BJ, White DA, Jennings JM, Van Eyk JE, Debaun MR, Everett A, Casella JF (2011) Am J Hematol 86: 427-9 Parent education and biologic factors influence on cognition in sickle cell anemia. King AA, Strouse JJ, Rodeghier MJ, Compas BE, Casella JF, McKinstry RC, Noetzel MJ, Quinn CT, Ichord R, Dowling MM, Miller JP, Debaun MR (2014) Am J Hematol 89: 162-7 Health-related quality of life in children with sickle cell anemia: impact of blood transfusion therapy. Beverung LM, Strouse JJ, Hulbert ML, Neville K, Liem RI, Inusa B, Fuh B, King A, Meier ER, Casella J, DeBaun MR, Panepinto JA, SIT trial investigators (2015) Am J Hematol 90: 139-43 Children with sickle cell anemia with normal transcranial Doppler ultrasounds and without silent infarcts have a low incidence of new strokes. Jordan LC, Roberts Williams DO, Rodeghier MJ, Covert Greene BV, Ponisio MR, Casella JF, McKinstry RC, Noetzel MJ, Kirkham FJ, Meier ER, Fuh B, McNaull M, Sarnaik S, Majumdar S, McCavit TL, DeBaun MR (2018) Am J Hematol 93: 760-768 Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease. Bhatnagar P, Barron-Casella E, Bean CJ, Milton JN, Baldwin CT, Steinberg MH, Debaun M, Casella JF, Arking DE (2013) PLoS One 8: e74193 Asymmetries in visual-spatial processing following childhood stroke. Schatz J, Craft S, Koby M, DeBaun MR (2004) Neuropsychology 18: 340-52 Peroxisome proliferator-activated receptor-gamma ligands reduce inflammation and infarction size in transient focal ischemia. Sundararajan S, Gamboa JL, Victor NA, Wanderi EW, Lust WD, Landreth GE (2005) Neuroscience 130: 685-96 Extension of the neuroprotective time window for thiazolidinediones in ischemic stroke is dependent on time of reperfusion. Gamboa J, Blankenship DA, Niemi JP, Landreth GE, Karl M, Hilow E, Sundararajan S (2010) Neuroscience 170: 846-57 Randomization is not associated with socio-economic and demographic factors in a multi-center clinical trial of children with sickle cell anemia. Roberts DO, Covert B, Rodeghier MJ, Parmar N, DeBaun MR, Thompson AA, Liem RI (2014) Pediatr Blood Cancer 61: 1529-1535 Blood transfusion therapy is feasible in a clinical trial setting in children with sickle cell disease and silent cerebral infarcts. King AA, Noetzel M, White DA, McKinstry RC, Debaun MR (2008) Pediatr Blood Cancer 50: 599-602
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