MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis. Rebustini IT, Myers C, Lassiter KS, Surmak A, Szabova L, Holmbeck K, Pedchenko V, Hudson BG, Hoffman MP (2009) Dev Cell 17: 482-93 Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Means AL, Ray KC, Singh AB, Washington MK, Whitehead RH, Harris RC, Wright CV, Coffey RJ, Leach SD (2003) Gastroenterology 124: 1020-36 Targeted Apoptosis of Parietal Cells Is Insufficient to Induce Metaplasia in Stomach. Burclaff J, Osaki LH, Liu D, Goldenring JR, Mills JC (2017) Gastroenterology 152: 762-766.e7 Transmembrane and soluble isoforms of heparin-binding epidermal growth factor-like growth factor regulate distinct processes in the pancreas. Ray KC, Blaine SA, Washington MK, Braun AH, Singh AB, Harris RC, Harding PA, Coffey RJ, Means AL (2009) Gastroenterology 137: 1785-94 Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Barnard JA, Beauchamp RD, Russell WE, Dubois RN, Coffey RJ (1995) Gastroenterology 108: 564-80 Induction of heparin-binding epidermal growth factor-like growth factor mRNA in rat kidney after acute injury. Homma T, Sakai M, Cheng HF, Yasuda T, Coffey RJ, Harris RC (1995) J Clin Invest 96: 1018-25 Helicobacter pylori upregulates expression of epidermal growth factor-related peptides, but inhibits their proliferative effect in MKN 28 gastric mucosal cells. Romano M, Ricci V, Di Popolo A, Sommi P, Del Vecchio Blanco C, Bruni CB, Ventura U, Cover TL, Blaser MJ, Coffey RJ, Zarrilli R (1998) J Clin Invest 101: 1604-13 Production of heparin binding epidermal growth factor-like growth factor in the early phase of regeneration after acute renal injury. Isolation and localization of bioactive molecules. Sakai M, Zhang M, Homma T, Garrick B, Abraham JA, McKanna JA, Harris RC (1997) J Clin Invest 99: 2128-38 Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells. Chen JK, Capdevila J, Harris RC (2002) Proc Natl Acad Sci U S A 99: 6029-34 Amphiregulin exosomes increase cancer cell invasion. Higginbotham JN, Demory Beckler M, Gephart JD, Franklin JL, Bogatcheva G, Kremers GJ, Piston DW, Ayers GD, McConnell RE, Tyska MJ, Coffey RJ (2011) Curr Biol 21: 779-86 Induction of collecting duct morphogenesis in vitro by heparin-binding epidermal growth factor-like growth factor. Takemura T, Hino S, Kuwajima H, Yanagida H, Okada M, Nagata M, Sasaki S, Barasch J, Harris RC, Yoshioka K (2001) J Am Soc Nephrol 12: 964-972 Role of membrane-bound heparin-binding epidermal growth factor-like growth factor (HB-EGF) in renal epithelial cell branching. Takemura T, Hino S, Okada M, Murata Y, Yanagida H, Ikeda M, Yoshioka K, Harris RC (2002) Kidney Int 61: 1968-79 IL-4/IL-13-mediated polarization of renal macrophages/dendritic cells to an M2a phenotype is essential for recovery from acute kidney injury. Zhang MZ, Wang X, Wang Y, Niu A, Wang S, Zou C, Harris RC (2017) Kidney Int 91: 375-386 Low nitric oxide bioavailability upregulates renal heparin binding EGF-like growth factor expression. Miyazawa T, Zeng F, Wang S, Fan X, Cheng H, Yang H, Bian A, Fogo AB, Harris RC (2013) Kidney Int 84: 1176-88 Coexpression of CD9 augments the ability of membrane-bound heparin-binding epidermal growth factor-like growth factor (proHB-EGF) to preserve renal epithelial cell viability. Takemura T, Hino S, Murata Y, Yanagida H, Okada M, Yoshioka K, Harris RC (1999) Kidney Int 55: 71-81 Lysophosphatidic acid, a disintegrin and metalloprotease-17 and heparin-binding epidermal growth factor-like growth factor in ovarian cancer: the first word, not the last. Braun AH, Coffey RJ (2005) Clin Cancer Res 11: 4639-43 Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia. Ray KC, Moss ME, Franklin JL, Weaver CJ, Higginbotham J, Song Y, Revetta FL, Blaine SA, Bridges LR, Guess KE, Coffey RJ, Crawford HC, Washington MK, Means AL (2014) Oncogene 33: 823-31 Membrane-associated HB-EGF modulates HGF-induced cellular responses in MDCK cells. Singh AB, Tsukada T, Zent R, Harris RC (2004) J Cell Sci 117: 1365-79 Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo. Bezbradica JS, Stanic AK, Matsuki N, Bour-Jordan H, Bluestone JA, Thomas JW, Unutmaz D, Van Kaer L, Joyce S (2005) J Immunol 174: 4696-705 Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite. Chen J, Chen JK, Falck JR, Guthi JS, Anjaiah S, Capdevila JH, Harris RC (2007) Mol Cell Biol 27: 3023-34 Prolactin and ErbB4/HER4 signaling interact via Janus kinase 2 to induce mammary epithelial cell gene expression differentiation. Muraoka-Cook RS, Sandahl M, Hunter D, Miraglia L, Earp HS (2008) Mol Endocrinol 22: 2307-21 A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor. Yan F, Liu L, Dempsey PJ, Tsai YH, Raines EW, Wilson CL, Cao H, Cao Z, Liu L, Polk DB (2013) J Biol Chem 288: 30742-30751 The membrane-bound form of heparin-binding epidermal growth factor-like growth factor promotes survival of cultured renal epithelial cells. Takemura T, Kondo S, Homma T, Sakai M, Harris RC (1997) J Biol Chem 272: 31036-42 Juxtacrine activation of epidermal growth factor (EGF) receptor by membrane-anchored heparin-binding EGF-like growth factor protects epithelial cells from anoikis while maintaining an epithelial phenotype. Singh AB, Sugimoto K, Harris RC (2007) J Biol Chem 282: 32890-901 Auto- and cross-induction within the mammalian epidermal growth factor-related peptide family. Barnard JA, Graves-Deal R, Pittelkow MR, DuBois R, Cook P, Ramsey GW, Bishop PR, Damstrup L, Coffey RJ (1994) J Biol Chem 269: 22817-22 Activation of Epidermal Growth Factor Receptor in Macrophages Mediates Feedback Inhibition of M2 Polarization and Gastrointestinal Tumor Cell Growth. Zhao G, Liu L, Peek RM, Hao X, Polk DB, Li H, Yan F (2016) J Biol Chem 291: 20462-72 ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis. Zeng F, Zhang MZ, Singh AB, Zent R, Harris RC (2007) Mol Biol Cell 18: 4446-56 TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase. Lee DC, Sunnarborg SW, Hinkle CL, Myers TJ, Stevenson MY, Russell WE, Castner BJ, Gerhart MJ, Paxton RJ, Black RA, Chang A, Jackson LF (2003) Ann N Y Acad Sci 995: 22-38 Regulation of heparin-binding EGF-like growth factor by miR-212 and acquired cetuximab-resistance in head and neck squamous cell carcinoma. Hatakeyama H, Cheng H, Wirth P, Counsell A, Marcrom SR, Wood CB, Pohlmann PR, Gilbert J, Murphy B, Yarbrough WG, Wheeler DL, Harari PM, Guo Y, Shyr Y, Slebos RJ, Chung CH (2010) PLoS One 5: e12702 Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance. Singh AB, Sugimoto K, Dhawan P, Harris RC (2007) Am J Physiol Cell Physiol 293: C1660-8 Epidermal growth factor receptor regulates pancreatic fibrosis. Blaine SA, Ray KC, Branch KM, Robinson PS, Whitehead RH, Means AL (2009) Am J Physiol Gastrointest Liver Physiol 297: G434-41 TNF-α converting enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survival. Hilliard VC, Frey MR, Dempsey PJ, Peek RM, Polk DB (2011) Am J Physiol Gastrointest Liver Physiol 301: G338-46 TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion. Le Bras GF, Taylor C, Koumangoye RB, Revetta F, Loomans HA, Andl CD (2015) Exp Cell Res 330: 29-42 Noninvasive quantitative magnetization transfer MRI reveals tubulointerstitial fibrosis in murine kidney. Wang F, Wang S, Zhang Y, Li K, Harris RC, Gore JC, Zhang MZ (2019) NMR Biomed 32: e4128
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