Dynamic Evolution of Nitric Oxide Detoxifying Flavohemoglobins, a Family of Single-Protein Metabolic Modules in Bacteria and Eukaryotes. Wisecaver JH, Alexander WG, King SB, Hittinger CT, Rokas A (2016) Mol Biol Evol 33: 1979-87 Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure. Boutaud O, Moore KP, Reeder BJ, Harry D, Howie AJ, Wang S, Carney CK, Masterson TS, Amin T, Wright DW, Wilson MT, Oates JA, Roberts LJ (2010) Proc Natl Acad Sci U S A 107: 2699-704 Enzymatic synthesis of a bicyclobutane fatty acid by a hemoprotein lipoxygenase fusion protein from the cyanobacterium Anabaena PCC 7120. Schneider C, Niisuke K, Boeglin WE, Voehler M, Stec DF, Porter NA, Brash AR (2007) Proc Natl Acad Sci U S A 104: 18941-5 Human mAbs to Staphylococcus aureus IsdA Provide Protection Through Both Heme-Blocking and Fc-Mediated Mechanisms. Bennett MR, Bombardi RG, Kose N, Parrish EH, Nagel MB, Petit RA, Read TD, Schey KL, Thomsen IP, Skaar EP, Crowe JE (2019) J Infect Dis 219: 1264-1273 Two heme-dependent terminal oxidases power Staphylococcus aureus organ-specific colonization of the vertebrate host. Hammer ND, Reniere ML, Cassat JE, Zhang Y, Hirsch AO, Indriati Hood M, Skaar EP (2013) mBio 4: The hydrophobic amino-terminal sequence of bovine 17 alpha-hydroxylase is required for the expression of a functional hemoprotein in COS 1 cells. Clark BJ, Waterman MR (1991) J Biol Chem 266: 5898-904 Cytochrome P450-type hydroxylation and epoxidation in a tyrosine-liganded hemoprotein, catalase-related allene oxide synthase. Boeglin WE, Brash AR (2012) J Biol Chem 287: 24139-47 Nitric oxide generation from nitroprusside by vascular tissue. Evidence that reduction of the nitroprusside anion and cyanide loss are required. Bates JN, Baker MT, Guerra R, Harrison DG (1991) Biochem Pharmacol 42 Suppl: S157-65 The flexible loop of Staphylococcus aureus IsdG is required for its degradation in the absence of heme. Reniere ML, Haley KP, Skaar EP (2011) Biochemistry 50: 6730-7 Reaction of nitric oxide with heme proteins: studies on metmyoglobin, opossum methemoglobin, and microperoxidase. Sharma VS, Isaacson RA, John ME, Waterman MR, Chevion M (1983) Biochemistry 22: 3897-902 Rational design of a functional metalloenzyme: introduction of a site for manganese binding and oxidation into a heme peroxidase. Wilcox SK, Putnam CD, Sastry M, Blankenship J, Chazin WJ, McRee DE, Goodin DB (1998) Biochemistry 37: 16853-62 Interpretations of cytochrome P450 mechanisms from kinetic studies. Guengerich FP, Bell LC, Okazaki O (1995) Biochimie 77: 573-80 Rate-limiting steps in cytochrome P450 catalysis. Guengerich FP (2002) Biol Chem 383: 1553-64 Activity of various metalloporphyrin protein complexes with microsomal heme oxygenase. Schacter BA, Waterman MR (1974) Life Sci 14: 47-53 Unusual susceptibility of heme proteins to damage by glucose during non-enzymatic glycation. Cussimanio BL, Booth AA, Todd P, Hudson BG, Khalifah RG (2003) Biophys Chem 105: 743-55
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