Human monoclonal Fab fragments derived from a combinatorial library bind to respiratory syncytial virus F glycoprotein and neutralize infectivity. Barbas CF, Crowe JE, Cababa D, Jones TM, Zebedee SL, Murphy BR, Chanock RM, Burton DR (1992) Proc Natl Acad Sci U S A 89: 10164-8 Preference for IgG mAb binding insulin in solution or on surfaces is related to immunoglobulin variable region structures. Tikhomirov OY, Thomas JW (1997) J Autoimmun 10: 541-9 An insertion mutation that distorts antibody binding site architecture enhances function of a human antibody. Krause JC, Ekiert DC, Tumpey TM, Smith PB, Wilson IA, Crowe JE (2011) mBio 2: e00345-10 Infant and adult human B cell responses to rotavirus share common immunodominant variable gene repertoires. Weitkamp JH, Kallewaard N, Kusuhara K, Bures E, Williams JV, LaFleur B, Greenberg HB, Crowe JE (2003) J Immunol 171: 4680-8 Reversion of somatic mutations of the respiratory syncytial virus-specific human monoclonal antibody Fab19 reveal a direct relationship between association rate and neutralizing potency. Bates JT, Keefer CJ, Utley TJ, Correia BE, Schief WR, Crowe JE (2013) J Immunol 190: 3732-9 Amino acid and nucleotide sequences of variable regions of mouse immunoglobulin light chains of the lambda 3-subtype. Reilly EB, Reilly RM, Breyer RM, Sauer RT, Eisen HN (1984) J Immunol 133: 471-5 B lymphocyte "original sin" in the bone marrow enhances islet autoreactivity in type 1 diabetes-prone nonobese diabetic mice. Henry-Bonami RA, Williams JM, Rachakonda AB, Karamali M, Kendall PL, Thomas JW (2013) J Immunol 190: 5992-6003 V region diversity in human anti-insulin antibodies. Preferential use of a VHIII gene subset. Thomas JW (1993) J Immunol 150: 1375-82 T cell-independent response to Brucella-insulin identifies a preimmune repertoire for insulin. Thomas JW, Kralick PM, Ewulonu UK (1997) J Immunol 159: 2334-41 Natural killer T cells restricted by the monomorphic MHC class 1b CD1d1 molecules behave like inflammatory cells. Mempel M, Ronet C, Suarez F, Gilleron M, Puzo G, Van Kaer L, Lehuen A, Kourilsky P, Gachelin G (2002) J Immunol 168: 365-71 B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice. Hulbert C, Riseili B, Rojas M, Thomas JW (2001) J Immunol 167: 5535-8 Immunodominance of the VH1-46 antibody gene segment in the primary repertoire of human rotavirus-specific B cells is reduced in the memory compartment through somatic mutation of nondominant clones. Tian C, Luskin GK, Dischert KM, Higginbotham JN, Shepherd BE, Crowe JE (2008) J Immunol 180: 3279-88 Multiple germline kappa light chains generate anti-insulin B cells in nonobese diabetic mice. Woodward EJ, Thomas JW (2005) J Immunol 175: 1073-9 Functional maturation of the human antibody response to rotavirus. Kallewaard NL, McKinney BA, Gu Y, Chen A, Prasad BV, Crowe JE (2008) J Immunol 180: 3980-9 Tertiary lymphoid structures in the pancreas promote selection of B lymphocytes in autoimmune diabetes. Kendall PL, Yu G, Woodward EJ, Thomas JW (2007) J Immunol 178: 5643-51 Localization of isoketal adducts in vivo using a single-chain antibody. Davies SS, Talati M, Wang X, Mernaugh RL, Amarnath V, Fessel J, Meyrick BO, Sheller J, Roberts LJ (2004) Free Radic Biol Med 36: 1163-74 Anti-insulin and regulatory anti-idiotypic antibodies use the same germ-line VHIX gene. Thomas JW (1992) Eur J Immunol 22: 2445-8 Expression and regulation of clonally ignorant B cells. Thomas JW, Hulbert C (1995) Ann N Y Acad Sci 764: 461-2 Heterogeneity among Helicobacter pylori strains in expression of the outer membrane protein BabA. Hennig EE, Mernaugh R, Edl J, Cao P, Cover TL (2004) Infect Immun 72: 3429-35 Improving Loop Modeling of the Antibody Complementarity-Determining Region 3 Using Knowledge-Based Restraints. Finn JA, Koehler Leman J, Willis JR, Cisneros A, Crowe JE, Meiler J (2016) PLoS One 11: e0154811 Tissue-specific expressed antibody variable gene repertoires. Briney BS, Willis JR, Finn JA, McKinney BA, Crowe JE (2014) PLoS One 9: e100839 Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire. Briney BS, Willis JR, Hicar MD, Thomas JW, Crowe JE (2012) Immunology 137: 56-64 Antigen-specific responses in autoimmunity and tolerance. Thomas JW (2001) Immunol Res 23: 235-44 Genetic and structural determinants of virus neutralizing antibodies. Crowe JE, Suara RO, Brock S, Kallewaard N, House F, Weitkamp JH (2001) Immunol Res 23: 135-45 Vkappa polymorphisms in NOD mice are spread throughout the entire immunoglobulin kappa locus and are shared by other autoimmune strains. Henry RA, Kendall PL, Woodward EJ, Hulbert C, Thomas JW (2010) Immunogenetics 62: 507-20 Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naïve and memory B cells. Tian C, Luskin GK, Dischert KM, Higginbotham JN, Shepherd BE, Crowe JE (2007) Mol Immunol 44: 2173-83 Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations. Hicar MD, Chen X, Kalams SA, Sojar H, Landucci G, Forthal DN, Spearman P, Crowe JE (2016) Mol Immunol 70: 94-103 The human neonatal B cell response to respiratory syncytial virus uses a biased antibody variable gene repertoire that lacks somatic mutations. Williams JV, Weitkamp JH, Blum DL, LaFleur BJ, Crowe JE (2009) Mol Immunol 47: 407-14 VH gene structure predicts a large potential anti-insulin repertoire. Mitchell HC, Thomas JW (1995) Mol Immunol 32: 311-21 Rotavirus-specific CD5+ B cells in young children exhibit a distinct antibody repertoire compared with CD5- B cells. Weitkamp JH, Lafleur BJ, Crowe JE (2006) Hum Immunol 67: 33-42 Natural evolution of a human virus-specific antibody gene repertoire by somatic hypermutation requires both hotspot-directed and randomly-directed processes. Weitkamp JH, Lafleur BJ, Greenberg HB, Crowe JE (2005) Hum Immunol 66: 666-76
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