The transcription factor NF-ATc is essential for cardiac valve formation. Ranger AM, Grusby MJ, Hodge MR, Gravallese EM, de la Brousse FC, Hoey T, Mickanin C, Baldwin HS, Glimcher LH (1998) Nature 392: 186-90 Inflammation, growth factors, and pulmonary vascular remodeling. Hassoun PM, Mouthon L, Barberà JA, Eddahibi S, Flores SC, Grimminger F, Jones PL, Maitland ML, Michelakis ED, Morrell NW, Newman JH, Rabinovitch M, Schermuly R, Stenmark KR, Voelkel NF, Yuan JX, Humbert M (2009) J Am Coll Cardiol 54: S10-S19 Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. Dai C, Hang Y, Shostak A, Poffenberger G, Hart N, Prasad N, Phillips N, Levy SE, Greiner DL, Shultz LD, Bottino R, Kim SK, Powers AC (2017) J Clin Invest 127: 3835-3844 Embryonic heart failure in NFATc1-/- mice: novel mechanistic insights from in utero ultrasound biomicroscopy. Phoon CK, Ji RP, Aristizábal O, Worrad DM, Zhou B, Baldwin HS, Turnbull DH (2004) Circ Res 95: 92-9 Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation. Wu B, Wang Y, Lui W, Langworthy M, Tompkins KL, Hatzopoulos AK, Baldwin HS, Zhou B (2011) Circ Res 109: 183-92 NFATc1 identifies a population of proximal tubule cell progenitors. Langworthy M, Zhou B, de Caestecker M, Moeckel G, Baldwin HS (2009) J Am Soc Nephrol 20: 311-21 Nuclear factor of activated T-cell activity is associated with metastatic capacity in colon cancer. Tripathi MK, Deane NG, Zhu J, An H, Mima S, Wang X, Padmanabhan S, Shi Z, Prodduturi N, Ciombor KK, Chen X, Washington MK, Zhang B, Beauchamp RD (2014) Cancer Res 74: 6947-57 Activation of NFAT signaling establishes a tumorigenic microenvironment through cell autonomous and non-cell autonomous mechanisms. Tripathi P, Wang Y, Coussens M, Manda KR, Casey AM, Lin C, Poyo E, Pfeifer JD, Basappa N, Bates CM, Ma L, Zhang H, Pan M, Ding L, Chen F (2014) Oncogene 33: 1840-9 Characterization of Nfatc1 regulation identifies an enhancer required for gene expression that is specific to pro-valve endocardial cells in the developing heart. Zhou B, Wu B, Tompkins KL, Boyer KL, Grindley JC, Baldwin HS (2005) Development 132: 1137-46 Myocardial differentiation is dependent upon endocardial signaling during early cardiogenesis . Saint-Jean L, Barkas N, Harmelink C, Tompkins KL, Oakey RJ, Baldwin HS (2019) Development 146: Regulation of NF-kappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-kappa B p50. Torgerson TR, Colosia AD, Donahue JP, Lin YZ, Hawiger J (1998) J Immunol 161: 6084-92 Impaired intracellular calcium mobilization and NFATc1 availability in tolerant anti-insulin B cells. Acevedo-Suárez CA, Kilkenny DM, Reich MB, Thomas JW (2006) J Immunol 177: 2234-41 CRACking the code without Rosetta: molecular regulation of calcium-stimulated gene transcription after T cell activation. Boothby M (2010) J Immunol 185: 4969-71 Regulatory defects in Cbl and mitogen-activated protein kinase (extracellular signal-related kinase) pathways cause persistent hyperexpression of CD40 ligand in human lupus T cells. Yi Y, McNerney M, Datta SK (2000) J Immunol 165: 6627-34 Regulation of the murine Nfatc1 gene by NFATc2. Zhou B, Cron RQ, Wu B, Genin A, Wang Z, Liu S, Robson P, Baldwin HS (2002) J Biol Chem 277: 10704-11 Cross-talk between G(s)- and G(q)-coupled pathways in regulation of interleukin-4 by A(2B) adenosine receptors in human mast cells. Ryzhov S, Goldstein AE, Biaggioni I, Feoktistov I (2006) Mol Pharmacol 70: 727-35 Fibroblast growth factor receptor-1 interacts with the T-cell receptor signalling pathway. Byrd VM, Kilkenny DM, Dikov MM, Reich MB, Rocheleau JV, Armistead WJ, Thomas JW, Miller GG (2003) Immunol Cell Biol 81: 440-50 Endocardial cells are a distinct endothelial lineage derived from Flk1+ multipotent cardiovascular progenitors. Misfeldt AM, Boyle SC, Tompkins KL, Bautch VL, Labosky PA, Baldwin HS (2009) Dev Biol 333: 78-89 RNA-Seq reveals a role for NFAT-signaling in human retinal microvascular endothelial cells treated with TNFα. Savage SR, Bretz CA, Penn JS (2015) PLoS One 10: e0116941 Transcriptional reprogramming during T helper cell differentiation. Aune TM (2001) Immunol Res 23: 193-204 NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis. Bretz CA, Savage SR, Capozzi ME, Suarez S, Penn JS (2015) Sci Rep 5: 14963 NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. Bonami RH, Wolfle WT, Thomas JW, Kendall PL (2014) Mol Immunol 62: 321-8 NFAT4 deficiency results in incomplete liver regeneration following partial hepatectomy. Pierre KB, Jones CM, Pierce JM, Nicoud IB, Earl TM, Chari RS (2009) J Surg Res 154: 226-33
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