Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients. Dutta R, McDonough J, Yin X, Peterson J, Chang A, Torres T, Gudz T, Macklin WB, Lewis DA, Fox RJ, Rudick R, Mirnics K, Trapp BD (2006) Ann Neurol 59: 478-89 The radial diffusivity and magnetization transfer pool size ratio are sensitive markers for demyelination in a rat model of type III multiple sclerosis (MS) lesions. Janve VA, Zu Z, Yao SY, Li K, Zhang FL, Wilson KJ, Ou X, Does MD, Subramaniam S, Gochberg DF (2013) Neuroimage 74: 298-305 Respiration and ROS production in brain and spinal cord mitochondria of transgenic rats with mutant G93a Cu/Zn-superoxide dismutase gene. Panov A, Kubalik N, Zinchenko N, Hemendinger R, Dikalov S, Bonkovsky HL (2011) Neurobiol Dis 44: 53-62 Astrogliopathy and oligodendrogliopathy are early events in CNS demyelination. Zhang F, Yao SY, Whetsell WO, Sriram S (2013) Glia 61: 1261-73 Copper accumulation and lipid oxidation precede inflammation and myelin lesions in N,N-diethyldithiocarbamate peripheral myelinopathy. Viquez OM, Valentine HL, Amarnath K, Milatovic D, Valentine WM (2008) Toxicol Appl Pharmacol 229: 77-85 Parenteral N,N-diethyldithiocarbamate produces segmental demyelination in the rat that is not dependent on cysteine carbamylation. Tonkin EG, Valentine HL, Zimmerman LJ, Valentine WM (2003) Toxicol Appl Pharmacol 189: 139-50 Peripheral nerve protein expression and carbonyl content in N,N-diethlydithiocarbamate myelinopathy. Viquez OM, Valentine HL, Friedman DB, Olson SJ, Valentine WM (2007) Chem Res Toxicol 20: 370-9 Nitrogen substituent polarity influences dithiocarbamate-mediated lipid oxidation, nerve copper accumulation, and myelin injury. Valentine HL, Viquez OM, Amarnath K, Amarnath V, Zyskowski J, Kassa EN, Valentine WM (2009) Chem Res Toxicol 22: 218-26 COX-2 inhibitors modulate IL-12 signaling through JAK-STAT pathway leading to Th1 response in experimental allergic encephalomyelitis. Muthian G, Raikwar HP, Johnson C, Rajasingh J, Kalgutkar A, Marnett LJ, Bright JJ (2006) J Clin Immunol 26: 73-85 Longitudinal assessment of spinal cord injuries in nonhuman primates with quantitative magnetization transfer. Wang F, Li K, Mishra A, Gochberg D, Min Chen L, Gore JC (2016) Magn Reson Med 75: 1685-96 LPS mediated injury to oligodendrocytes is mediated by the activation of nNOS: relevance to human demyelinating disease. Yao S, Pandey P, Ljunggren-Rose A, Sriram S (2010) Nitric Oxide 22: 197-204 Activation of NOD2/RIPK2 pathway induces mitochondrial injury to oligodendrocyte precursor cells in vitro and CNS demyelination in vivo. Natarajan C, Yao SY, Zhang F, Sriram S (2013) J Neuroimmunol 265: 51-60 Role of glial cells in innate immunity and their role in CNS demyelination. Sriram S (2011) J Neuroimmunol 239: 13-20 TNF-receptor 1 deficiency fails to alter the clinical and pathological course in mice with globoid cell leukodystrophy (twitcher mice) but affords protection following LPS challenge. Pedchenko TV, Bronshteyn IG, LeVine SM (2000) J Neuroimmunol 110: 186-94 Desferrioxamine suppresses experimental allergic encephalomyelitis induced by MBP in SJL mice. Pedchenko TV, LeVine SM (1998) J Neuroimmunol 84: 188-97 Multicomponent T2 analysis of dithiocarbamate-mediated peripheral nerve demyelination. Valentine HL, Does MD, Marshall V, Tonkin EG, Valentine WM (2007) Neurotoxicology 28: 645-54
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