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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Connections to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine are shown below. Double-click or tap a node for more information.
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- Fetal neuronal grafts in monkeys given methylphenyltetrahydropyridine.
Redmond DE, Sladek JR, Roth RH, Collier TJ, Elsworth JD, Deutch AY, Haber S
(1986) Lancet 1: 1125-7 - Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease.
Ahmed MR, Berthet A, Bychkov E, Porras G, Li Q, Bioulac BH, Carl YT, Bloch B, Kook S, Aubert I, Dovero S, Doudnikoff E, Gurevich VV, Gurevich EV, Bezard E
(2010) Sci Transl Med 2: 28ra28 - Cortical regulation of striatal medium spiny neuron dendritic remodeling in parkinsonism: modulation of glutamate release reverses dopamine depletion-induced dendritic spine loss.
Garcia BG, Neely MD, Deutch AY
(2010) Cereb Cortex 20: 2423-32 - Developmental exposure to the pesticide dieldrin alters the dopamine system and increases neurotoxicity in an animal model of Parkinson's disease.
Richardson JR, Caudle WM, Wang M, Dean ED, Pennell KD, Miller GW
(2006) FASEB J 20: 1695-7 - Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.
Bajpai P, Sangar MC, Singh S, Tang W, Bansal S, Chowdhury G, Cheng Q, Fang JK, Martin MV, Guengerich FP, Avadhani NG
(2013) J Biol Chem 288: 4436-51 - Mitochondrially targeted cytochrome P450 2D6 is involved in monomethylamine-induced neuronal damage in mouse models.
Chattopadhyay M, Chowdhury AR, Feng T, Assenmacher CA, Radaelli E, Guengerich FP, Avadhani NG
(2019) J Biol Chem 294: 10336-10348 - Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity.
Hanna IH, Krauser JA, Cai H, Kim MS, Guengerich FP
(2001) J Biol Chem 276: 39553-61 - Functional MRI of basal ganglia responsiveness to levodopa in parkinsonian rhesus monkeys.
Chen Q, Andersen AH, Zhang Z, Ovadia A, Cass WA, Gash DM, Avison MJ
(1999) Exp Neurol 158: 63-75 - Reversal of parkinsonism by fetal nerve cell transplants in primate brain.
Sladek JR, Collier TJ, Haber SN, Deutch AY, Elsworth JD, Roth RH, Redmond DE
(1987) Ann N Y Acad Sci 495: 641-57 - Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism.
Sladek JR, Redmond DE, Collier TJ, Haber SN, Elsworth JD, Deutch AY, Roth RH
(1987) Prog Brain Res 71: 309-23 - Cortical serotonin and norepinephrine denervation in parkinsonism: preferential loss of the beaded serotonin innervation.
Nayyar T, Bubser M, Ferguson MC, Neely MD, Shawn Goodwin J, Montine TJ, Deutch AY, Ansah TA
(2009) Eur J Neurosci 30: 207-16 - Decreased Rhes mRNA levels in the brain of patients with Parkinson's disease and MPTP-treated macaques.
Napolitano F, Booth Warren E, Migliarini S, Punzo D, Errico F, Li Q, Thiolat ML, Vescovi AL, Calabresi P, Bezard E, Morelli M, Konradi C, Pasqualetti M, Usiello A
(2017) PLoS One 12: e0181677 - 25-Hydroxyvitamin D depletion does not exacerbate MPTP-induced dopamine neuron damage in mice.
Dean ED, Mexas LM, Cápiro NL, McKeon JE, DeLong MR, Pennell KD, Doorn JA, Tangpricha V, Miller GW, Evatt ML
(2012) PLoS One 7: e39227 - Physical activity is linked to ceruloplasmin in the striatum of intact but not MPTP-treated primates.
Leak RK, Garbett KA, Dettmer AM, Zhang Z, Mirnics K, Cameron JL
(2012) Cell Tissue Res 350: 401-7 - Triggering endogenous neuroprotective processes through exercise in models of dopamine deficiency.
Zigmond MJ, Cameron JL, Leak RK, Mirnics K, Russell VA, Smeyne RJ, Smith AD
(2009) Parkinsonism Relat Disord 15 Suppl 3: S42-5 - Morphological, neurochemical, and behavioral characterizations associated with the combined treatment of diethyldithiocarbamate and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.
Yurek DM, Deutch AY, Roth RH, Sladek JR
(1989) Brain Res 497: 250-9 - Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines and metabolites in primate brain and CSF.
Elsworth JD, Deutch AY, Redmond DE, Sladek JR, Roth RH
(1987) Brain Res 415: 293-9 - Differential responsiveness to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatum.
Elsworth JD, Deutch AY, Redmond DE, Sladek JR, Roth RH
(1987) Life Sci 40: 193-202 - Profiling genes related to mitochondrial function in mice treated with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Gu G, Deutch AY, Franklin J, Levy S, Wallace DC, Zhang J
(2003) Biochem Biophys Res Commun 308: 197-205 - Mapping drug-induced changes in cerebral R2* by Multiple Gradient Recalled Echo functional MRI.
Chen Q, Andersen AH, Zhang Z, Ovadia A, Gash DM, Avison MJ
(1996) Magn Reson Imaging 14: 469-76 - Principal component analysis of the dynamic response measured by fMRI: a generalized linear systems framework.
Andersen AH, Gash DM, Avison MJ
(1999) Magn Reson Imaging 17: 795-815 - Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Deutch AY, Elsworth JD, Goldstein M, Fuxe K, Redmond DE, Sladek JR, Roth RH
(1986) Neurosci Lett 68: 51-6 - MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate.
Elsworth JD, Deutch AY, Redmond DE, Sladek JR, Roth RH
(1990) Neurosci Lett 114: 316-22
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