Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics Z, Lee VM, Hersh LB, Sapolsky RM, Mirnics K, Sisodia SS (2005) Cell 120: 701-13 DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes. Mirnics ZK, Mirnics K, Terrano D, Lewis DA, Sisodia SS, Schor NF (2003) Mol Psychiatry 8: 863-78 Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Huppert SS, Ilagan MX, De Strooper B, Kopan R (2005) Dev Cell 8: 677-88 A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2. Zhang X, Garbett K, Veeraraghavalu K, Wilburn B, Gilmore R, Mirnics K, Sisodia SS (2012) J Neurosci 32: 8633-48 Presenilin-1-dependent transcriptome changes. Mirnics K, Korade Z, Arion D, Lazarov O, Unger T, Macioce M, Sabatini M, Terrano D, Douglass KC, Schor NF, Sisodia SS (2005) J Neurosci 25: 1571-8 Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice. Bernardo A, Harrison FE, McCord M, Zhao J, Bruchey A, Davies SS, Jackson Roberts L, Mathews PM, Matsuoka Y, Ariga T, Yu RK, Thompson R, McDonald MP (2009) Neurobiol Aging 30: 1777-91 Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics. Rao SK, Ross JM, Harrison FE, Bernardo A, Reiserer RS, Reiserer RS, Mobley JA, McDonald MP (2015) Neurobiol Dis 78: 45-55 P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1. Mirnics ZK, Yan C, Portugal C, Kim TW, Saragovi HU, Sisodia SS, Mirnics K, Schor NF (2005) Neurobiol Dis 20: 969-85 Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer's disease and a novel protective role for ascorbate. Dixit S, Fessel JP, Harrison FE (2017) Free Radic Biol Med 112: 515-523 Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease. Lewis TL, Cao D, Lu H, Mans RA, Su YR, Jungbauer L, Linton MF, Fazio S, LaDu MJ, Li L (2010) J Biol Chem 285: 36958-68 Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers. Mahoney MB, Parks AL, Ruddy DA, Tiong SY, Esengil H, Phan AC, Philandrinos P, Winter CG, Chatterjee R, Huppert K, Fisher WW, L'Archeveque L, Mapa FA, Woo W, Ellis MC, Curtis D (2006) Genetics 172: 2309-24 Aerosol Delivery of Curcumin Reduced Amyloid-β Deposition and Improved Cognitive Performance in a Transgenic Model of Alzheimer's Disease. McClure R, Ong H, Janve V, Barton S, Zhu M, Li B, Dawes M, Jerome WG, Anderson A, Massion P, Gore JC, Pham W (2017) J Alzheimers Dis 55: 797-811 Inhalable curcumin: offering the potential for translation to imaging and treatment of Alzheimer's disease. McClure R, Yanagisawa D, Stec D, Abdollahian D, Koktysh D, Xhillari D, Jaeger R, Stanwood G, Chekmenev E, Tooyama I, Gore JC, Pham W (2015) J Alzheimers Dis 44: 283-95 Diminished taxol/GTP-stimulated tubulin polymerization in diseased region of brain from patients with late-onset or inherited Alzheimer's disease or frontotemporal dementia with parkinsonism linked to chromosome-17 but not individuals with mild cognitive impairment. Boutté AM, Neely MD, Bird TD, Montine KS, Montine TJ (2005) J Alzheimers Dis 8: 1-6 Transcriptome differences between the frontal cortex and hippocampus of wild-type and humanized presenilin-1 transgenic mice. Unger T, Korade Z, Lazarov O, Terrano D, Schor NF, Sisodia SS, Mirnics K (2005) Am J Geriatr Psychiatry 13: 1041-51 Vitamin C deficiency in the brain impairs cognition, increases amyloid accumulation and deposition, and oxidative stress in APP/PSEN1 and normally aging mice. Dixit S, Bernardo A, Walker JM, Kennard JA, Kim GY, Kessler ES, Harrison FE (2015) ACS Chem Neurosci 6: 570-81 Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Yang X, Klein R, Tian X, Cheng HT, Kopan R, Shen J (2004) Dev Biol 269: 81-94 True and false discovery in DNA microarray experiments: transcriptome changes in the hippocampus of presenilin 1 mutant mice. Unger T, Korade Z, Lazarov O, Terrano D, Sisodia SS, Mirnics K (2005) Methods 37: 261-73 Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice. Kennard JA, Harrison FE (2014) Behav Brain Res 264: 34-42 Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type mice. Harrison FE, Hosseini AH, McDonald MP, May JM (2009) Pharmacol Biochem Behav 93: 443-50 Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic mice. Harrison FE, May JM, McDonald MP (2010) Pharmacol Biochem Behav 94: 543-52 Ultrastructural studies in APP/PS1 mice expressing human ApoE isoforms: implications for Alzheimer's disease. Dikranian K, Kim J, Stewart FR, Levy MA, Holtzman DM (2012) Int J Clin Exp Pathol 5: 482-95 Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease. Warner TA, Kang JQ, Kennard JA, Harrison FE (2015) Epilepsy Res 110: 20-5 Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice. Harrison FE, Allard J, Bixler R, Usoh C, Li L, May JM, McDonald MP (2009) Nutr Neurosci 12: 203-18
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.