Small science: high stakes. Gamazon ER (2012) Science 338: 883 De novo DNA demethylation and noncoding transcription define active intergenic regulatory elements. Schlesinger F, Smith AD, Gingeras TR, Hannon GJ, Hodges E (2013) Genome Res 23: 1601-14 Phosphorylation-dependent derepression by the response regulator HnoC in the Shewanella oneidensis nitric oxide signaling network. Plate L, Marletta MA (2013) Proc Natl Acad Sci U S A 110: E4648-57 Control of BMP gene expression by long-range regulatory elements. Pregizer S, Mortlock DP (2009) Cytokine Growth Factor Rev 20: 509-15 Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans. Ferguson JF, Meyer NJ, Qu L, Xue C, Liu Y, DerOhannessian SL, Rushefski M, Paschos GK, Tang S, Schadt EE, Li M, Christie JD, Reilly MP (2015) Hum Mol Genet 24: 1801-12 Melanocyte-lineage expression of Cre recombinase using Mitf regulatory elements. Alizadeh A, Fitch KR, Niswender CM, McKnight GS, Barsh GS (2008) Pigment Cell Melanoma Res 21: 63-9 Distal regions of the human IFNG locus direct cell type-specific expression. Collins PL, Chang S, Henderson M, Soutto M, Davis GM, McLoed AG, Townsend MJ, Glimcher LH, Mortlock DP, Aune TM (2010) J Immunol 185: 1492-501 Separate transcriptionally regulated pathways specify distinct classes of sister dendrites in a nociceptive neuron. O'Brien BMJ, Palumbos SD, Novakovic M, Shang X, Sundararajan L, Miller DM (2017) Dev Biol 432: 248-257 Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Boyer DF, Fujitani Y, Gannon M, Powers AC, Stein RW, Wright CV (2006) Dev Biol 298: 616-31 Acinetobacter baumannii response to host-mediated zinc limitation requires the transcriptional regulator Zur. Mortensen BL, Rathi S, Chazin WJ, Skaar EP (2014) J Bacteriol 196: 2616-26 Negative regulation of Vsx1 by its paralog Chx10/Vsx2 is conserved in the vertebrate retina. Clark AM, Yun S, Veien ES, Wu YY, Chow RL, Dorsky RI, Levine EM (2008) Brain Res 1192: 99-113 Repressive BMP2 gene regulatory elements near the BMP2 promoter. Jiang S, Chandler RL, Fritz DT, Mortlock DP, Rogers MB (2010) Biochem Biophys Res Commun 392: 124-8 Leishmania-induced repression of selected non-coding RNA genes containing B-box element at their promoters in alternatively polarized M2 macrophages. Farrow AL, Rana T, Mittal MK, Misra S, Chaudhuri G (2011) Mol Cell Biochem 350: 47-57
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