Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic. Yang T, Atack TC, Stroud DM, Zhang W, Hall L, Roden DM (2012) Circ Res 111: 322-32 Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension. Fessel JP, Porter NA, Moore KP, Sheller JR, Roberts LJ (2002) Proc Natl Acad Sci U S A 99: 16713-8 Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress. Bastarache JA, Sebag SC, Clune JK, Grove BS, Lawson WE, Janz DR, Roberts LJ, Dworski R, Mackman N, Ware LB (2012) Thorax 67: 1032-9 Insulin sensitively controls the glucagon response to mild hypoglycemia in the dog. Igawa K, Mugavero M, Shiota M, Neal DW, Cherrington AD (2002) Diabetes 51: 3033-42 Effects of insulin deficiency or excess on hepatic gluconeogenic flux during glycogenolytic inhibition in the conscious dog. Edgerton DS, Cardin S, Pan C, Neal D, Farmer B, Converse M, Cherrington AD (2002) Diabetes 51: 3151-62 Isofurans: novel products of lipid peroxidation that define the occurrence of oxidant injury in settings of elevated oxygen tension. Fessel JP, Jackson Roberts L (2005) Antioxid Redox Signal 7: 202-9 Are isofurans and neuroprostanes increased after subarachnoid hemorrhage and traumatic brain injury? Corcoran TB, Mas E, Barden AE, Durand T, Galano JM, Roberts LJ, Phillips M, Ho KM, Mori TA (2011) Antioxid Redox Signal 15: 2663-7 Is there a role for isofurans and neuroprostanes in pre-eclampsia and normal pregnancy? Barden AE, Corcoran TB, Mas E, Durand T, Galano JM, Roberts LJ, Paech M, Muchatuta NA, Phillips M, Mori TA (2012) Antioxid Redox Signal 16: 165-9 Postoperative acute kidney injury is associated with hemoglobinemia and an enhanced oxidative stress response. Billings FT, Ball SK, Roberts LJ, Pretorius M (2011) Free Radic Biol Med 50: 1480-7 Overexpression of Cu/Zn-superoxide dismutase and/or catalase accelerates benzo(a)pyrene detoxification by upregulation of the aryl hydrocarbon receptor in mouse endothelial cells. Wang Z, Yang H, Ramesh A, Roberts LJ, Zhou L, Lin X, Zhao Y, Guo Z (2009) Free Radic Biol Med 47: 1221-9 Measurement of F2- isoprostanes and isofurans using gas chromatography-mass spectrometry. Milne GL, Gao B, Terry ES, Zackert WE, Sanchez SC (2013) Free Radic Biol Med 59: 36-44 Hemoglobin attenuates the effects of inspired oxygen on plasma isofurans in humans during upper-limb surgery. Corcoran TB, Barden AE, Mas E, Grape S, Koren V, Phillips M, Roberts LJ, Mori TA (2011) Free Radic Biol Med 51: 1235-9 Effects of hyperglycemia on hepatic gluconeogenic flux during glycogen phosphorylase inhibition in the conscious dog. Edgerton DS, Cardin S, Neal D, Farmer B, Lautz M, Pan C, Cherrington AD (2004) Am J Physiol Endocrinol Metab 286: E510-22 New insights regarding tissue Se and Hg interactions on oxidative stress from plasma IsoP and IsoF measures in the Canadian Inuit population. Alkazemi D, Egeland GM, Roberts LJ, Chan HM, Kubow S (2013) J Lipid Res 54: 1972-9 Seizure-induced formation of isofurans: novel products of lipid peroxidation whose formation is positively modulated by oxygen tension. Patel M, Liang LP, Hou H, Williams BB, Kmiec M, Swartz HM, Fessel JP, Roberts LJ (2008) J Neurochem 104: 264-70 Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease. Fessel JP, Hulette C, Powell S, Roberts LJ, Zhang J (2003) J Neurochem 85: 645-50 Comparison of rates of enzymatic oxidation of aflatoxin B1, aflatoxin G1, and sterigmatocystin and activities of the epoxides in forming guanyl-N7 adducts and inducing different genetic responses. Baertschi SW, Raney KD, Shimada T, Harris TM, Guengerich FP (1989) Chem Res Toxicol 2: 114-2 Plasma biomarkers of oxidative stress and genetic variants in age-related macular degeneration. Brantley MA, Osborn MP, Sanders BJ, Rezaei KA, Lu P, Li C, Milne GL, Cai J, Sternberg P (2012) Am J Ophthalmol 153: 460-467.e1 The short-term effects of antioxidant and zinc supplements on oxidative stress biomarker levels in plasma: a pilot investigation. Brantley MA, Osborn MP, Sanders BJ, Rezaei KA, Lu P, Li C, Milne GL, Cai J, Sternberg P (2012) Am J Ophthalmol 153: 1104-9.e2 Isoprostane and isofuran lipid mediators accumulate in stored red blood cells and influence platelet function in vitro. Spinelli SL, Lannan KL, Casey AE, Croasdell A, Curran TM, Henrichs KF, Pollock SJ, Milne GA, Refaai MA, Francis CW, Phipps RP, Blumberg N (2014) Transfusion 54: 1569-79 PET radiotracer [¹⁸F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation. Perrone MG, Malerba P, Uddin J, Vitale P, Panella A, Crews BC, Daniel CK, Ghebreselasie K, Nickels M, Tantawy MN, Manning HC, Marnett LJ, Scilimati A (2014) Eur J Med Chem 80: 562-568 A phase I trial of CEP-701 + gemcitabine in patients with advanced adenocarcinoma of the pancreas. Chan E, Mulkerin D, Rothenberg M, Holen KD, Lockhart AC, Thomas J, Berlin J (2008) Invest New Drugs 26: 241-7 DNA abasic lesions in a different light: solution structure of an endogenous topoisomerase II poison. Cline SD, Jones WR, Stone MP, Osheroff N (1999) Biochemistry 38: 15500-7 Bolaamphiphile-class surfactants can stabilize and support the function of solubilized integral membrane proteins. Li Q, Mittal R, Huang L, Travis B, Sanders CR (2009) Biochemistry 48: 11606-8 To Avoid Chasing Incorrect Chemical Structures of Chiral Compounds: Raman Optical Activity and Vibrational Circular Dichroism Spectroscopies. Polavarapu PL, Covington CL, Raghavan V (2017) Chemphyschem 18: 2459-2465 A nomenclature system for isofurans. Taber DF, Fessel JP, Roberts LJ (2004) Prostaglandins Other Lipid Mediat 73: 47-50 Lead optimization of the VU0486321 series of mGlu(1) PAMs. Part 2: SAR of alternative 3-methyl heterocycles and progress towards an in vivo tool. Garcia-Barrantes PM, Cho HP, Metts AM, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW (2016) Bioorg Med Chem Lett 26: 751-756 Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 1: SAR of modifications to the central aryl core. Garcia-Barrantes PM, Cho HP, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW (2015) Bioorg Med Chem Lett 25: 5107-10 Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs. Garcia-Barrantes PM, Cho HP, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW (2016) Bioorg Med Chem Lett 26: 1869-72 Clinical impact of double protease inhibitor boosting with lopinavir/ritonavir and amprenavir as part of salvage antiretroviral therapy. Loutfy M, Raboud J, Thompson C, Tseng A, Abdurrahman Z, Kovacs C, Rachlis A, Phillips E, Rubin G, Gough K, Walmsley S (2003) HIV Clin Trials 4: 301-10 The biochemistry of the isoprostane, neuroprostane, and isofuran pathways of lipid peroxidation. Roberts LJ, Fessel JP (2004) Chem Phys Lipids 128: 173-86 Measurement of products of docosahexaenoic acid peroxidation, neuroprostanes, and neurofurans. Arneson KO, Roberts LJ (2007) Methods Enzymol 433: 127-43 Association of plasma F2-isoprostanes and isofurans concentrations with erythropoiesis-stimulating agent resistance in maintenance hemodialysis patients. Rivara MB, Ikizler TA, Ellis CD, Mehrotra R, Himmelfarb J (2015) BMC Nephrol 16: 79
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