Keyword Connections

•  Claus Schneider
•  David Gailani

•  H. Ruley
•  Raymond Burk

•  Richard Armstrong
•  Tina Iverson

Resources

• Targeting vector linearization

Communities

• No matching connections

Publications

• Effect of bradykinin-receptor blockade on the response to angiotensin-converting-enzyme inhibitor in normotensive and hypertensive subjects.
  Gainer JV, Morrow JD, Loveland A, King DJ, Brown NJ
  (1998) N Engl J Med 339: 1285-92
• Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis.
  Pedchenko V, Bondar O, Fogo AB, Vanacore R, Voziyan P, Kitching AR, Wieslander J, Kashtan C, Borza DB, Neilson EG, Wilson CB, Hudson BG
  (2010) N Engl J Med 363: 343-54
• Intensive blood-pressure control in hypertensive chronic kidney disease.
  Appel LJ, Wright JT, Greene T, Agodoa LY, Astor BC, Bakris GL, Cleveland WH, Charleston J, Contreras G, Faulkner ML, Gabbai FB, Gassman JJ, Hebert LA, Jamerson KA, Kopple JD, Kusek JW, Lash JP, Lea JP, Lewis JB, Lipkowitz MS, Massry SG, Miller ER, Norris K, Phillips RA, Pogue VA, Randall OS, Rostand SG, Smogorzewski MJ, Toto RD, Wang X, AASK Collaborative Research Group
  (2010) N Engl J Med 363: 918-29
• Genetic determinants of response to warfarin during initial anticoagulation.
  Schwarz UI, Ritchie MD, Bradford Y, Li C, Dudek SM, Frye-Anderson A, Kim RB, Roden DM, Stein CM
  (2008) N Engl J Med 358: 999-1008
• Major congenital malformations after first-trimester exposure to ACE inhibitors.
  Cooper WO, Hernandez-Diaz S, Arbogast PG, Dudley JA, Dyer S, Gideon PS, Hall K, Ray WA
  (2006) N Engl J Med 354: 2443-51
• Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling pathways.
  Rouzer CA, Marnett LJ
  (2011) Chem Rev 111: 5899-921
• Intracellular signalling. Key enzyme in leptin-induced anorexia.
  Niswender KD, Morton GJ, Stearns WH, Rhodes CJ, Myers MG, Schwartz MW
  (2001) Nature 413: 794-5
• Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.
  Huang DT, Hunt HW, Zhuang M, Ohi MD, Holton JM, Schulman BA
  (2007) Nature 445: 394-8
• Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation.
  Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, Chen Z, Lee MK, Attar N, Sazegar H, Chodon T, Nelson SF, McArthur G, Sosman JA, Ribas A, Lo RS
  (2010) Nature 468: 973-7
• Clustered illegitimate recombination events in mammalian cells involving very short sequence homologies.
  Ruley HE, Fried M
  (1983) Nature 304: 181-4
• NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP.
  Sun C, Cai M, Gunasekera AH, Meadows RP, Wang H, Chen J, Zhang H, Wu W, Xu N, Ng SC, Fesik SW
  (1999) Nature 401: 818-22
• Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis.
  Yin XM, Wang K, Gross A, Zhao Y, Zinkel S, Klocke B, Roth KA, Korsmeyer SJ
  (1999) Nature 400: 886-91
• Syk tyrosine kinase required for mouse viability and B-cell development.
  Cheng AM, Rowley B, Pao W, Hayday A, Bolen JB, Pawson T
  (1995) Nature 378: 303-6
• Proof of principle for epitope-focused vaccine design.
  Correia BE, Bates JT, Loomis RJ, Baneyx G, Carrico C, Jardine JG, Rupert P, Correnti C, Kalyuzhniy O, Vittal V, Connell MJ, Stevens E, Schroeter A, Chen M, Macpherson S, Serra AM, Adachi Y, Holmes MA, Li Y, Klevit RE, Graham BS, Wyatt RT, Baker D, Strong RK, Crowe JE, Johnson PR, Schief WR
  (2014) Nature 507: 201-6
• Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation.
  Friedrich R, Panizzi P, Fuentes-Prior P, Richter K, Verhamme I, Anderson PJ, Kawabata S, Huber R, Bode W, Bock PE
  (2003) Nature 425: 535-9
• Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.
  Prahallad A, Sun C, Huang S, Di Nicolantonio F, Salazar R, Zecchin D, Beijersbergen RL, Bardelli A, Bernards R
  (2012) Nature 483: 100-3
• Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75.
  Casaccia-Bonnefil P, Carter BD, Dobrowsky RT, Chao MV
  (1996) Nature 383: 716-9
• High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP.
  Rodríguez CI, Buchholz F, Galloway J, Sequerra R, Kasper J, Ayala R, Stewart AF, Dymecki SM
  (2000) Nat Genet 25: 139-40
• Cytochrome P450 enzymes in the generation of commercial products.
  Guengerich FP
  (2002) Nat Rev Drug Discov 1: 359-66
• Drug metabolism by Escherichia coli expressing human cytochromes P450.
  Parikh A, Gillam EM, Guengerich FP
  (1997) Nat Biotechnol 15: 784-8
• Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
  Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, Palmer M, Shamji AF, Wawer MJ, McManus O, Wu M, Zou B, Yu H, Golden JE, Schoenen FJ, Simeonov A, Jadhav A, Jackson MR, Pinkerton AB, Chung TD, Griffin PR, Cravatt BF, Hodder PS, Roush WR, Roberts E, Chung DH, Jonsson CB, Noah JW, Severson WE, Ananthan S, Edwards B, Oprea TI, Conn PJ, Hopkins CR, Wood MR, Stauffer SR, Emmitte KA, NIH Molecular Libraries Project Team
  (2015) Cell 161: 1252-65
• Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin.
  Winder DG, Mansuy IM, Osman M, Moallem TM, Kandel ER
  (1998) Cell 92: 25-37
• Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins.
  Rameh LE, Chen CS, Cantley LC
  (1995) Cell 83: 821-30
• Roles of serine/threonine phosphatases in hippocampal synaptic plasticity.
  Winder DG, Sweatt JD
  (2001) Nat Rev Neurosci 2: 461-74
• Allosteric activators of glucokinase: potential role in diabetes therapy.
  Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF
  (2003) Science 301: 370-3
• Histamine inhibition of neutrophil lysosomal enzyme release: an H2 histamine receptor response.
  Busse WW, Sosman J
  (1976) Science 194: 737-8
• Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants.
  Ramamoorthy S, Blakely RD
  (1999) Science 285: 763-6
• Cell cycle regulation of myosin-V by calcium/calmodulin-dependent protein kinase II.
  Karcher RL, Roland JT, Zappacosta F, Huddleston MJ, Annan RS, Carr SA, Gelfand VI
  (2001) Science 293: 1317-20
• Neurosteroids: cytochrome P-450scc in rat brain.
  Le Goascogne C, Robel P, Gouézou M, Sananès N, Baulieu EE, Waterman M
  (1987) Science 237: 1212-5
• Expression of bovine 17 alpha-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS 1) cells.
  Zuber MX, Simpson ER, Waterman MR
  (1986) Science 234: 1258-61
• Purification of an allene oxide synthase and identification of the enzyme as a cytochrome P-450.
  Song WC, Brash AR
  (1991) Science 253: 781-4
• TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
  Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE, Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, He L, Cominelli F, Di Martino L, Djuric Z, Milne GL, Chance M, Sanabria J, Dealwis C, Mikkola D, Naidoo J, Wei S, Tai HH, Gerson SL, Ready JM, Posner B, Willson JK, Markowitz SD
  (2015) Science 348: aaa2340
• Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase.
  Gould KL, Moreno S, Tonks NK, Nurse P
  (1990) Science 250: 1573-6
• A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.
  Westphal RS, Anderson KA, Means AR, Wadzinski BE
  (1998) Science 280: 1258-61
• A sperm cytoskeletal protein that signals oocyte meiotic maturation and ovulation.
  Miller MA, Nguyen VQ, Lee MH, Kosinski M, Schedl T, Caprioli RM, Greenstein D
  (2001) Science 291: 2144-7
• The structure of human 5-lipoxygenase.
  Gilbert NC, Bartlett SG, Waight MT, Neau DB, Boeglin WE, Brash AR, Newcomer ME
  (2011) Science 331: 217-9