Regulation of net hepatic glucose uptake in vivo. Pagliassotti MJ, Cherrington AD (1992) Annu Rev Physiol 54: 847-60 Insulin's direct effects on the liver dominate the control of hepatic glucose production. Edgerton DS, Lautz M, Scott M, Everett CA, Stettler KM, Neal DW, Chu CA, Cherrington AD (2006) J Clin Invest 116: 521-7 Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration. Myers SR, McGuinness OP, Neal DW, Cherrington AD (1991) J Clin Invest 87: 930-9 Acute reactant cytokines and neutrophil adhesion after warm ischemia in cirrhotic and noncirrhotic human livers. Clavien PA, Camargo CA, Gorczynski R, Washington MK, Levy GA, Langer B, Greig PD (1996) Hepatology 23: 1456-63 Direct and indirect effects of insulin on glucose uptake and storage by the liver. Satake S, Moore MC, Igawa K, Converse M, Farmer B, Neal DW, Cherrington AD (2002) Diabetes 51: 1663-71 Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes. Gregory JM, Kraft G, Scott MF, Neal DW, Farmer B, Smith MS, Hastings JR, Allen EJ, Donahue EP, Rivera N, Winnick JJ, Edgerton DS, Nishimura E, Fledelius C, Brand CL, Cherrington AD (2015) Diabetes 64: 3439-51 In the absence of counterregulatory hormones, the increase in hepatic glucose production during insulin-induced hypoglycemia in the dog is initiated in the liver rather than the brain. Connolly CC, Myers SR, Neal DW, Hastings JR, Cherrington AD (1996) Diabetes 45: 1805-13 A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Sindelar DK, Balcom JH, Chu CA, Neal DW, Cherrington AD (1996) Diabetes 45: 1594-604 Liver glycogen loading dampens glycogen synthesis seen in response to either hyperinsulinemia or intraportal glucose infusion. Winnick JJ, An Z, Kraft G, Ramnanan CJ, Irimia JM, Smith M, Lautz M, Roach PJ, Cherrington AD (2013) Diabetes 62: 96-101 Portal vein glucose entry triggers a coordinated cellular response that potentiates hepatic glucose uptake and storage in normal but not high-fat/high-fructose-fed dogs. Coate KC, Kraft G, Irimia JM, Smith MS, Farmer B, Neal DW, Roach PJ, Shiota M, Cherrington AD (2013) Diabetes 62: 392-400 Magnitude of negative arterial-portal glucose gradient alters net hepatic glucose balance in conscious dogs. Pagliassotti MJ, Myers SR, Moore MC, Neal DW, Cherrington AD (1991) Diabetes 40: 1659-68 Suppression of endogenous glucose production by mild hyperinsulinemia during exercise is determined predominantly by portal venous insulin. Camacho RC, Pencek RR, Lacy DB, James FD, Wasserman DH (2004) Diabetes 53: 285-93 Hepatic glycogen supercompensation activates AMP-activated protein kinase, impairs insulin signaling, and reduces glycogen deposition in the liver. Winnick JJ, An Z, Ramnanan CJ, Smith M, Irimia JM, Neal DW, Moore MC, Roach PJ, Cherrington AD (2011) Diabetes 60: 398-407 A cyclic guanosine monophosphate-dependent pathway can regulate net hepatic glucose uptake in vivo. An Z, Winnick JJ, Moore MC, Farmer B, Smith M, Irimia JM, Roach PJ, Cherrington AD (2012) Diabetes 61: 2433-41 Portal venous 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion overcomes hyperinsulinemic suppression of endogenous glucose output. Camacho RC, Pencek RR, Lacy DB, James FD, Donahue EP, Wasserman DH (2005) Diabetes 54: 373-82 Inhalation of insulin (Exubera) is associated with augmented disposal of portally infused glucose in dogs. Edgerton DS, Neal DW, Scott M, Bowen L, Wilson W, Hobbs CH, Leach C, Sivakumaran S, Strack TR, Cherrington AD (2005) Diabetes 54: 1164-70 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside causes acute hepatic insulin resistance in vivo. Pencek RR, Shearer J, Camacho RC, James FD, Lacy DB, Fueger PT, Donahue EP, Snead W, Wasserman DH (2005) Diabetes 54: 355-60 Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog. Shiota M, Galassetti P, Monohan M, Neal DW, Cherrington AD (1998) Diabetes 47: 867-73 Basal hepatic glucose production is regulated by the portal vein insulin concentration. Sindelar DK, Chu CA, Venson P, Donahue EP, Neal DW, Cherrington AD (1998) Diabetes 47: 523-9 Central versus peripheral glucose sensing and the response to hypoglycemia. Cherrington AD (2008) Diabetes 57: 1158-9 Portal infusion of amino acids is more efficient than peripheral infusion in stimulating liver protein synthesis at the same hepatic amino acid load in dogs. Dardevet D, Kimball SR, Jefferson LS, Cherrington AD, Rémond D, DiCostanzo CA, Moore MC (2008) Am J Clin Nutr 88: 986-96 Hyperinsulinemia after pancreatic transplantation. Prediction by a novel computer model and in vivo verification. Earnhardt RC, Kindler DD, Weaver AM, Cornett G, Elahi D, Veldhuis JD, Hanks JB (1993) Ann Surg 218: 428-41; discussion 441-3 Liver ischemia contributes to early islet failure following intraportal transplantation: benefits of liver ischemic-preconditioning. Yin D, Ding JW, Shen J, Ma L, Hara M, Chong AS (2006) Am J Transplant 6: 60-8 Intrahepatic bile duct regeneration in mice does not require Hnf6 or Notch signaling through Rbpj. Walter TJ, Vanderpool C, Cast AE, Huppert SS (2014) Am J Pathol 184: 1479-88 Impact of portal glucose delivery on glucose metabolism in conscious, unrestrained mice. Chueh FY, Malabanan C, McGuinness OP (2006) Am J Physiol Endocrinol Metab 291: E1206-11 Effects of the nitric oxide donor SIN-1 on net hepatic glucose uptake in the conscious dog. An Z, DiCostanzo CA, Moore MC, Edgerton DS, Dardevet DP, Neal DW, Cherrington AD (2008) Am J Physiol Endocrinol Metab 294: E300-6 Portal infusion of a selective serotonin reuptake inhibitor enhances hepatic glucose disposal in conscious dogs. Moore MC, DiCostanzo CA, Dardevet D, Lautz M, Farmer B, Neal DW, Cherrington AD (2004) Am J Physiol Endocrinol Metab 287: E1057-63 Effects of intraportal exenatide on hepatic glucose metabolism in the conscious dog. Edgerton DS, An Z, Johnson KM, Farmer T, Farmer B, Neal D, Cherrington AD (2013) Am J Physiol Endocrinol Metab 305: E132-9 Splanchnic free fatty acid kinetics. Jensen MD, Cardin S, Edgerton D, Cherrington A (2003) Am J Physiol Endocrinol Metab 284: E1140-8 Portal glucose delivery stimulates muscle but not liver protein metabolism. Kraft G, Coate KC, Dardevet D, Farmer B, Donahue EP, Williams PE, Cherrington AD, Moore MC (2012) Am J Physiol Endocrinol Metab 303: E1202-11 Glucose autoregulation is the dominant component of the hormone-independent counterregulatory response to hypoglycemia in the conscious dog. Gregory JM, Rivera N, Kraft G, Winnick JJ, Farmer B, Allen EJ, Donahue EP, Smith MS, Edgerton DS, Williams PE, Cherrington AD (2017) Am J Physiol Endocrinol Metab 313: E273-E283 Impact of chronic fructose infusion on hepatic metabolism during TPN administration. Donmoyer CM, Lacy DB, Zhang Y, Chen SS, McGuinness OP (2002) Am J Physiol Endocrinol Metab 283: E1151-8 Importance of the hepatic arterial glucose level in generation of the portal signal in conscious dogs. Hsieh PS, Moore MC, Neal DW, Cherrington AD (2000) Am J Physiol Endocrinol Metab 279: E284-92 Intraportal GLP-1 infusion increases nonhepatic glucose utilization without changing pancreatic hormone levels. Johnson KM, Edgerton DS, Rodewald T, Scott M, Farmer B, Neal D, Cherrington AD (2007) Am J Physiol Endocrinol Metab 293: E1085-91 Unlike mice, dogs exhibit effective glucoregulation during low-dose portal and peripheral glucose infusion. Moore MC, Cardin S, Edgerton DS, Farmer B, Neal DW, Lautz M, Cherrington AD (2004) Am J Physiol Endocrinol Metab 286: E226-33 Effect of intraportal glucagon-like peptide-1 on glucose metabolism in conscious dogs. Nishizawa M, Moore MC, Shiota M, Gustavson SM, Snead WL, Neal DW, Cherrington AD (2003) Am J Physiol Endocrinol Metab 284: E1027-36 Combined intraportal infusion of acetylcholine and adrenergic blockers augments net hepatic glucose uptake. Shiota M, Jackson P, Galassetti P, Scott M, Neal DW, Cherrington AD (2000) Am J Physiol Endocrinol Metab 278: E544-52 Portal 5-hydroxytryptophan infusion enhances glucose disposal in conscious dogs. Moore MC, Kimura K, Shibata H, Honjoh T, Saito M, Everett CA, Smith MS, Cherrington AD (2005) Am J Physiol Endocrinol Metab 289: E225-31 Hepatic portal venous delivery of a nitric oxide synthase inhibitor enhances net hepatic glucose uptake. Moore MC, Dicostanzo CA, Smith MS, Farmer B, Rodewald TD, Neal DW, Williams PE, Cherrington AD (2008) Am J Physiol Endocrinol Metab 294: E768-77 Comparison of the physiological relevance of systemic vs. portal insulin delivery to evaluate whole body glucose flux during an insulin clamp. Farmer TD, Jenkins EC, O'Brien TP, McCoy GA, Havlik AE, Nass ER, Nicholson WE, Printz RL, Shiota M (2015) Am J Physiol Endocrinol Metab 308: E206-22
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