-
Communities
-
Explore Vanderbilt communities
By latest
Featured community
Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
-
- Resources
-
People
-
Publications
-
Explore publications
-
Keyword Connections
Connections to bcl-X Protein are shown below. Double-click or tap a node for more information.
Please note that publication matches are limited to 40 in this view. If you expected more, please view all publication matches for bcl-X Protein.
Members
- No matching connections
Resources
- No matching connections
Communities
- No matching connections
Publications
- Bcl-x(L) forms an ion channel in synthetic lipid membranes.
Minn AJ, Vélez P, Schendel SL, Liang H, Muchmore SW, Fesik SW, Fill M, Thompson CB
(1997) Nature 385: 353-7 - X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.
Muchmore SW, Sattler M, Liang H, Meadows RP, Harlan JE, Yoon HS, Nettesheim D, Chang BS, Thompson CB, Wong SL, Ng SL, Fesik SW
(1996) Nature 381: 335-41 - Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.
Sattler M, Liang H, Nettesheim D, Meadows RP, Harlan JE, Eberstadt M, Yoon HS, Shuker SB, Chang BS, Minn AJ, Thompson CB, Fesik SW
(1997) Science 275: 983-6 - p53 has a direct apoptogenic role at the mitochondria.
Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, Moll UM
(2003) Mol Cell 11: 577-90 - 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation.
Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, Greenberg ME
(2000) Mol Cell 6: 41-51 - Selective regulation of Bcl-XL by a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies.
Packham G, White EL, Eischen CM, Yang H, Parganas E, Ihle JN, Grillot DA, Zambetti GP, Nuñez G, Cleveland JL
(1998) Genes Dev 12: 2475-87 - Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms.
Minn AJ, Kettlun CS, Liang H, Kelekar A, Vander Heiden MG, Chang BS, Fesik SW, Fill M, Thompson CB
(1999) EMBO J 18: 632-43 - Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2.
Chang BS, Minn AJ, Muchmore SW, Fesik SW, Thompson CB
(1997) EMBO J 16: 968-77 - The role of NF-{kappa}B-1 and NF-{kappa}B-2-mediated resistance to apoptosis in lymphomas.
Bernal-Mizrachi L, Lovly CM, Ratner L
(2006) Proc Natl Acad Sci U S A 103: 9220-5 - Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus.
Huang Q, Petros AM, Virgin HW, Fesik SW, Olejniczak ET
(2002) Proc Natl Acad Sci U S A 99: 3428-33 - Solution structure of the antiapoptotic protein bcl-2.
Petros AM, Medek A, Nettesheim DG, Kim DH, Yoon HS, Swift K, Matayoshi ED, Oltersdorf T, Fesik SW
(2001) Proc Natl Acad Sci U S A 98: 3012-7 - Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation.
Chiang CW, Harris G, Ellig C, Masters SC, Subramanian R, Shenolikar S, Wadzinski BE, Yang E
(2001) Blood 97: 1289-97 - Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts.
Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, Lodish HF
(2001) Blood 98: 3261-73 - Kinome-wide functional screen identifies role of PLK1 in hormone-independent, ER-positive breast cancer.
Bhola NE, Jansen VM, Bafna S, Giltnane JM, Balko JM, Estrada MV, Meszoely I, Mayer I, Abramson V, Ye F, Sanders M, Dugger TC, Allen EV, Arteaga CL
(2015) Cancer Res 75: 405-14 - A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo.
Shoemaker AR, Oleksijew A, Bauch J, Belli BA, Borre T, Bruncko M, Deckwirth T, Frost DJ, Jarvis K, Joseph MK, Marsh K, McClellan W, Nellans H, Ng S, Nimmer P, O'Connor JM, Oltersdorf T, Qing W, Shen W, Stavropoulos J, Tahir SK, Wang B, Warner R, Zhang H, Fesik SW, Rosenberg SH, Elmore SW
(2006) Cancer Res 66: 8731-9 - Antiapoptotic function of NF-kappaB in T lymphocytes is influenced by their differentiation status: roles of Fas, c-FLIP, and Bcl-xL.
Mora AL, Corn RA, Stanic AK, Goenka S, Aronica M, Stanley S, Ballard DW, Joyce S, Boothby M
(2003) Cell Death Differ 10: 1032-44 - PPAR-gamma agonist protects podocytes from injury.
Kanjanabuch T, Ma LJ, Chen J, Pozzi A, Guan Y, Mundel P, Fogo AB
(2007) Kidney Int 71: 1232-9 - RAF265 inhibits the growth of advanced human melanoma tumors.
Su Y, Vilgelm AE, Kelley MC, Hawkins OE, Liu Y, Boyd KL, Kantrow S, Splittgerber RC, Short SP, Sobolik T, Zaja-Milatovic S, Dahlman KB, Amiri KI, Jiang A, Lu P, Shyr Y, Stuart DD, Levy S, Sosman JA, Richmond A
(2012) Clin Cancer Res 18: 2184-98 - Resistance to TRAIL is mediated by DARPP-32 in gastric cancer.
Belkhiri A, Zhu S, Chen Z, Soutto M, El-Rifai W
(2012) Clin Cancer Res 18: 3889-900 - Constitutive expression of BCL-X(L) in the T lineage attenuates collagen-induced arthritis in Bcl-X(L) transgenic mice.
Chen Y, Rosloniec E, Price J, Boothby M, Chen J
(2002) Arthritis Rheum 46: 514-21 - Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1.
Eischen CM, Packham G, Nip J, Fee BE, Hiebert SW, Zambetti GP, Cleveland JL
(2001) Oncogene 20: 6983-93 - BAD/BCL-[X(L)] heterodimerization leads to bypass of G0/G1 arrest.
Chattopadhyay A, Chiang CW, Yang E
(2001) Oncogene 20: 4507-18 - 'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.
Lin X, Morgan-Lappe S, Huang X, Li L, Zakula DM, Vernetti LA, Fesik SW, Shen Y
(2007) Oncogene 26: 3972-9 - Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma.
Crowther AJ, Gama V, Bevilacqua A, Chang SX, Yuan H, Deshmukh M, Gershon TR
(2013) J Neurosci 33: 18098-108 - 6-Mercaptopurine, monocytes, and atherosclerosis.
Linton MF, Fazio S
(2010) Arterioscler Thromb Vasc Biol 30: 1494-6 - Intrinsic apoptotic pathway activation increases response to anti-estrogens in luminal breast cancers.
Williams MM, Lee L, Werfel T, Joly MMM, Hicks DJ, Rahman B, Elion D, McKernan C, Sanchez V, Estrada MV, Massarweh S, Elledge R, Duvall C, Cook RS
(2018) Cell Death Dis 9: 21 - Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
Friberg A, Vigil D, Zhao B, Daniels RN, Burke JP, Garcia-Barrantes PM, Camper D, Chauder BA, Lee T, Olejniczak ET, Fesik SW
(2013) J Med Chem 56: 15-30 - Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis.
Petros AM, Dinges J, Augeri DJ, Baumeister SA, Betebenner DA, Bures MG, Elmore SW, Hajduk PJ, Joseph MK, Landis SK, Nettesheim DG, Rosenberg SH, Shen W, Thomas S, Wang X, Zanze I, Zhang H, Fesik SW
(2006) J Med Chem 49: 656-63 - Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
Wendt MD, Shen W, Kunzer A, McClellan WJ, Bruncko M, Oost TK, Ding H, Joseph MK, Zhang H, Nimmer PM, Ng SC, Shoemaker AR, Petros AM, Oleksijew A, Marsh K, Bauch J, Oltersdorf T, Belli BA, Martineau D, Fesik SW, Rosenberg SH, Elmore SW
(2006) J Med Chem 49: 1165-81 - Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
Bruncko M, Oost TK, Belli BA, Ding H, Joseph MK, Kunzer A, Martineau D, McClellan WJ, Mitten M, Ng SC, Nimmer PM, Oltersdorf T, Park CM, Petros AM, Shoemaker AR, Song X, Wang X, Wendt MD, Zhang H, Fesik SW, Rosenberg SH, Elmore SW
(2007) J Med Chem 50: 641-62 - Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design.
Burke JP, Bian Z, Shaw S, Zhao B, Goodwin CM, Belmar J, Browning CF, Vigil D, Friberg A, Camper DV, Rossanese OW, Lee T, Olejniczak ET, Fesik SW
(2015) J Med Chem 58: 3794-805 - Synergy between phosphatidylinositol 3-kinase/Akt pathway and Bcl-xL in the control of apoptosis in adenocarcinoma cells of the lung.
Qian J, Zou Y, Rahman JS, Lu B, Massion PP
(2009) Mol Cancer Ther 8: 101-9 - IL-15 regulates homeostasis and terminal maturation of NKT cells.
Gordy LE, Bezbradica JS, Flyak AI, Spencer CT, Dunkle A, Sun J, Stanic AK, Boothby MR, He YW, Zhao Z, Van Kaer L, Joyce S
(2011) J Immunol 187: 6335-45 - A critical role for protein kinase C-theta-mediated T cell survival in cardiac allograft rejection.
Manicassamy S, Yin D, Zhang Z, Molinero LL, Alegre ML, Sun Z
(2008) J Immunol 181: 513-20 - NF-kappa B controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes.
Stanic AK, Bezbradica JS, Park JJ, Matsuki N, Mora AL, Van Kaer L, Boothby MR, Joyce S
(2004) J Immunol 172: 2265-73 - Histone Deacetylase 3 Is Required for Efficient T Cell Development.
Stengel KR, Zhao Y, Klus NJ, Kaiser JF, Gordy LE, Joyce S, Hiebert SW, Summers AR
(2015) Mol Cell Biol 35: 3854-65 - The BH3 domain of Bcl-x(S) is required for inhibition of the antiapoptotic function of Bcl-x(L).
Chang BS, Kelekar A, Harris MH, Harlan JE, Fesik SW, Thompson CB
(1999) Mol Cell Biol 19: 6673-81 - Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.
Kelekar A, Chang BS, Harlan JE, Fesik SW, Thompson CB
(1997) Mol Cell Biol 17: 7040-6 - Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis.
Eischen CM, Woo D, Roussel MF, Cleveland JL
(2001) Mol Cell Biol 21: 5063-70 - Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis.
Chiang CW, Kanies C, Kim KW, Fang WB, Parkhurst C, Xie M, Henry T, Yang E
(2003) Mol Cell Biol 23: 6350-62
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.
