Model for a factor IX activation complex on blood platelets: dimeric conformation of factor XIa is essential. Gailani D, Ho D, Sun MF, Cheng Q, Walsh PN (2001) Blood 97: 3117-22 Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis. Tucker EI, Verbout NG, Leung PY, Hurst S, McCarty OJ, Gailani D, Gruber A (2012) Blood 119: 4762-8 A cofactor for factor XI activation. Gailani D (2011) Blood 118: 6730-1 Factor IX is activated in vivo by the tissue factor mechanism. Bauer KA, Kass BL, ten Cate H, Hawiger JJ, Rosenberg RD (1990) Blood 76: 731-6 The dimeric structure of factor XI and zymogen activation. Geng Y, Verhamme IM, Smith SB, Sun MF, Matafonov A, Cheng Q, Smith SA, Morrissey JH, Gailani D (2013) Blood 121: 3962-9 Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor. Puy C, Tucker EI, Matafonov A, Cheng Q, Zientek KD, Gailani D, Gruber A, McCarty OJ (2015) Blood 125: 1488-96 Factor XI as a target for antithrombotic therapy. Bane CE, Gailani D (2014) Drug Discov Today 19: 1454-8 Sulfated pentagalloylglucoside is a potent, allosteric, and selective inhibitor of factor XIa. Al-Horani RA, Ponnusamy P, Mehta AY, Gailani D, Desai UR (2013) J Med Chem 56: 867-78 Discovery of allosteric modulators of factor XIa by targeting hydrophobic domains adjacent to its heparin-binding site. Karuturi R, Al-Horani RA, Mehta SC, Gailani D, Desai UR (2013) J Med Chem 56: 2415-28 Structural role of Gly(193) in serine proteases: investigations of a G555E (GLY193 in chymotrypsin) mutant of blood coagulation factor XI. Schmidt AE, Ogawa T, Gailani D, Bajaj SP (2004) J Biol Chem 279: 29485-92 A sequential mechanism for exosite-mediated factor IX activation by factor XIa. Geng Y, Verhamme IM, Messer A, Sun MF, Smith SB, Bajaj SP, Gailani D (2012) J Biol Chem 287: 38200-9 The factor IX gamma-carboxyglutamic acid (Gla) domain is involved in interactions between factor IX and factor XIa. Aktimur A, Gabriel MA, Gailani D, Toomey JR (2003) J Biol Chem 278: 7981-7 Characterization of a heparin binding site on the heavy chain of factor XI. Zhao M, Abdel-Razek T, Sun MF, Gailani D (1998) J Biol Chem 273: 31153-9 Identification of a factor IX binding site on the third apple domain of activated factor XI. Sun Y, Gailani D (1996) J Biol Chem 271: 29023-8 Exosite-mediated substrate recognition of factor IX by factor XIa. The factor XIa heavy chain is required for initial recognition of factor IX. Ogawa T, Verhamme IM, Sun MF, Bock PE, Gailani D (2005) J Biol Chem 280: 23523-30 Characterization of Novel Forms of Coagulation Factor XIa: independence of factor XIa subunits in factor IX activation. Smith SB, Verhamme IM, Sun MF, Bock PE, Gailani D (2008) J Biol Chem 283: 6696-705 Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes. Itakura A, Verbout NG, Phillips KG, Insall RH, Gailani D, Tucker EI, Gruber A, McCarty OJ (2011) J Leukoc Biol 90: 923-7 Factor XI activation by thrombin and factor XIa. Gailani D, Broze GJ (1993) Semin Thromb Hemost 19: 396-404 Contributions of basic amino acids in the autolysis loop of factor XIa to serpin specificity. Rezaie AR, Sun MF, Gailani D (2006) Biochemistry 45: 9427-33 Functional role of residue 193 (chymotrypsin numbering) in serine proteases: influence of side chain length and beta-branching on the catalytic activity of blood coagulation factor XIa. Schmidt AE, Sun MF, Ogawa T, Bajaj SP, Gailani D (2008) Biochemistry 47: 1326-35 Characterization of a heparin-binding site on the catalytic domain of factor XIa: mechanism of heparin acceleration of factor XIa inhibition by the serpins antithrombin and C1-inhibitor. Yang L, Sun MF, Gailani D, Rezaie AR (2009) Biochemistry 48: 1517-24 The mechanism underlying activation of factor IX by factor XIa. Gailani D, Geng Y, Verhamme I, Sun MF, Bajaj SP, Messer A, Emsley J (2014) Thromb Res 133 Suppl 1: S48-51
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