Identification of the endothelial cell binding site for factor IX. Cheung WF, van den Born J, Kühn K, Kjellén L, Hudson BG, Stafford DW (1996) Proc Natl Acad Sci U S A 93: 11068-73 Fixing human factor IX (fIX): correction of a cryptic RNA splice enables the production of biologically active fIX in the mammary gland of transgenic mice. Yull F, Harold G, Wallace R, Cowper A, Percy J, Cottingham I, Clark AJ (1995) Proc Natl Acad Sci U S A 92: 10899-903 Model for a factor IX activation complex on blood platelets: dimeric conformation of factor XIa is essential. Gailani D, Ho D, Sun MF, Cheng Q, Walsh PN (2001) Blood 97: 3117-22 Factor IX is activated in vivo by the tissue factor mechanism. Bauer KA, Kass BL, ten Cate H, Hawiger JJ, Rosenberg RD (1990) Blood 76: 731-6 Defective binding of factor XI-N248 to activated human platelets. Sun MF, Baglia FA, Ho D, Martincic D, Ware RE, Walsh PN, Gailani D (2001) Blood 98: 125-9 Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor. Puy C, Tucker EI, Matafonov A, Cheng Q, Zientek KD, Gailani D, Gruber A, McCarty OJ (2015) Blood 125: 1488-96 The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice. Cheng Q, Zhao Y, Lawson WE, Polosukhin VV, Johnson JE, Blackwell TS, Gailani D (2005) Blood 106: 3055-7 Structure and function of factor XI. Emsley J, McEwan PA, Gailani D (2010) Blood 115: 2569-77 Mammalian cDNA and prokaryotic reporter sequences silence adjacent transgenes in transgenic mice. Clark AJ, Harold G, Yull FE (1997) Nucleic Acids Res 25: 1009-14 Exosite-mediated substrate recognition of factor IX by factor XIa. The factor XIa heavy chain is required for initial recognition of factor IX. Ogawa T, Verhamme IM, Sun MF, Bock PE, Gailani D (2005) J Biol Chem 280: 23523-30 A sequential mechanism for exosite-mediated factor IX activation by factor XIa. Geng Y, Verhamme IM, Messer A, Sun MF, Smith SB, Bajaj SP, Gailani D (2012) J Biol Chem 287: 38200-9 The factor IX gamma-carboxyglutamic acid (Gla) domain is involved in interactions between factor IX and factor XIa. Aktimur A, Gabriel MA, Gailani D, Toomey JR (2003) J Biol Chem 278: 7981-7 Identification of amino acids in the factor XI apple 3 domain required for activation of factor IX. Sun MF, Zhao M, Gailani D (1999) J Biol Chem 274: 36373-8 Identification of a factor IX binding site on the third apple domain of activated factor XI. Sun Y, Gailani D (1996) J Biol Chem 271: 29023-8 Characterization of Novel Forms of Coagulation Factor XIa: independence of factor XIa subunits in factor IX activation. Smith SB, Verhamme IM, Sun MF, Bock PE, Gailani D (2008) J Biol Chem 283: 6696-705 Effect of nuclear localization and hydrodynamic delivery-induced cell division on phiC31 integrase activity. Woodard LE, Hillman RT, Keravala A, Lee S, Calos MP (2010) Gene Ther 17: 217-26 Long-term phenotypic correction in factor IX knockout mice by using ΦC31 integrase-mediated gene therapy. Keravala A, Chavez CL, Hu G, Woodard LE, Monahan PE, Calos MP (2011) Gene Ther 18: 842-8 Females with FVIII and FIX deficiency have reduced joint range of motion. Sidonio RF, Mili FD, Li T, Miller CH, Hooper WC, DeBaun MR, Soucie M, Hemophilia Treatment Centers Network (2014) Am J Hematol 89: 831-6 Functional role of residue 193 (chymotrypsin numbering) in serine proteases: influence of side chain length and beta-branching on the catalytic activity of blood coagulation factor XIa. Schmidt AE, Sun MF, Ogawa T, Bajaj SP, Gailani D (2008) Biochemistry 47: 1326-35 The mechanism underlying activation of factor IX by factor XIa. Gailani D, Geng Y, Verhamme I, Sun MF, Bajaj SP, Messer A, Emsley J (2014) Thromb Res 133 Suppl 1: S48-51 Activation of factor IX by factor XIa. Gailani D (2000) Trends Cardiovasc Med 10: 198-204
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.