-
Communities
-
Explore Vanderbilt communities
By latest
Featured community
Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
-
- Resources
-
People
-
Publications
-
Explore publications
-
Keyword Connections
Connections to Receptor, Insulin are shown below. Double-click or tap a node for more information.
Please note that publication matches are limited to 40 in this view. If you expected more, please view all publication matches for Receptor, Insulin.
Members
- No matching connections
Resources
- No matching connections
Communities
- No matching connections
Publications
- Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM
(2001) Nature 413: 131-8 - Disruption of IRS-2 causes type 2 diabetes in mice.
Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF
(1998) Nature 391: 900-4 - Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.
Nakae J, Biggs WH, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D
(2002) Nat Genet 32: 245-53 - Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins.
Rameh LE, Chen CS, Cantley LC
(1995) Cell 83: 821-30 - Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.
Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR
(1999) Cell 96: 329-39 - Suppression of aging in mice by the hormone Klotho.
Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M
(2005) Science 309: 1829-33 - TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.
Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N
(2006) Nat Med 12: 107-13 - Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N
(2007) Nat Med 13: 1193-202 - Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.
Scarlett JM, Rojas JM, Matsen ME, Kaiyala KJ, Stefanovski D, Bergman RN, Nguyen HT, Dorfman MD, Lantier L, Wasserman DH, Mirzadeh Z, Unterman TG, Morton GJ, Schwartz MW
(2016) Nat Med 22: 800-6 - Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer.
Lovly CM, McDonald NT, Chen H, Ortiz-Cuaran S, Heukamp LC, Yan Y, Florin A, Ozretić L, Lim D, Wang L, Chen Z, Chen X, Lu P, Paik PK, Shen R, Jin H, Buettner R, Ansén S, Perner S, Brockmann M, Bos M, Wolf J, Gardizi M, Wright GM, Solomon B, Russell PA, Rogers TM, Suehara Y, Red-Brewer M, Tieu R, de Stanchina E, Wang Q, Zhao Z, Johnson DH, Horn L, Wong KK, Thomas RK, Ladanyi M, Pao W
(2014) Nat Med 20: 1027-34 - A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.
Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton L, Lefai E, Simon MC, Maher JJ, Mithieux G, Rajas F, Annes J, McGuinness OP, Thurston G, Giaccia AJ, Kuo CJ
(2013) Nat Med 19: 1331-1337 - Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.
Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, Kahn CR
(2000) Mol Cell 6: 87-97 - Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis.
Baumgartl J, Baudler S, Scherner M, Babaev V, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton M, Brüning JC
(2006) Cell Metab 3: 247-56 - Insulin signaling in alpha cells modulates glucagon secretion in vivo.
Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, Herrera PL, Polonsky KS, McGuinness OP, Kulkarni RN
(2009) Cell Metab 9: 350-61 - Pdx1 restores beta cell function in Irs2 knockout mice.
Kushner JA, Ye J, Schubert M, Burks DJ, Dow MA, Flint CL, Dutta S, Wright CV, Montminy MR, White MF
(2002) J Clin Invest 109: 1193-201 - Monocyte-T lymphocyte interaction for regulation of insulin receptors of the activated T lymphocyte.
Helderman JH, Ayuso R, Rosenstock J, Raskin P
(1987) J Clin Invest 79: 566-71 - Role of insulin in the intermediary metabolism of the activated thymic-derived lymphocyte.
Helderman JH
(1981) J Clin Invest 67: 1636-42 - Rapid mixed lymphocyte culture testing by analysis of the insulin receptor on alloactivated T lymphocytes: implications for human tissue typing.
Helderman JH, Strom TB, Garovoy MR
(1981) J Clin Invest 67: 509-13 - Insulin exits skeletal muscle capillaries by fluid-phase transport.
Williams IM, Valenzuela FA, Kahl SD, Ramkrishna D, Mezo AR, Young JD, Wells KS, Wasserman DH
(2018) J Clin Invest 128: 699-714 - Emergence of insulin receptors upon alloimmune T cells in the rat.
Helderman JH, Strom TB
(1977) J Clin Invest 59: 338-44 - The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.
Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH, Wright CV, White MF, Arden KC, Accili D
(2002) J Clin Invest 110: 1839-47 - The role of hepatic insulin receptors in the regulation of glucose production.
Cherrington AD
(2005) J Clin Invest 115: 1136-9 - Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins.
Guix M, Faber AC, Wang SE, Olivares MG, Song Y, Qu S, Rinehart C, Seidel B, Yee D, Arteaga CL, Engelman JA
(2008) J Clin Invest 118: 2609-19 - The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation.
Carricaburu V, Lamia KA, Lo E, Favereaux L, Payrastre B, Cantley LC, Rameh LE
(2003) Proc Natl Acad Sci U S A 100: 9867-72 - Another version of the human insulin receptor kinase domain: expression, purification, and characterization.
Villalba M, Wente SR, Russell DS, Ahn JC, Reichelderfer CF, Rosen OM
(1989) Proc Natl Acad Sci U S A 86: 7848-52 - Mn2(+)-binding properties of a recombinant protein-tyrosine kinase derived from the human insulin receptor.
Wente SR, Villalba M, Schramm VL, Rosen OM
(1990) Proc Natl Acad Sci U S A 87: 2805-9 - A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer.
Fox EM, Miller TW, Balko JM, Kuba MG, Sánchez V, Smith RA, Liu S, González-Angulo AM, Mills GB, Ye F, Shyr Y, Manning HC, Buck E, Arteaga CL
(2011) Cancer Res 71: 6773-84 - Four RFLPs of the human insulin receptor gene: PstI, KpnI, RsaI (2 RFLPs).
Cox NJ, Spielman RS, Kahn CR, Müller-Wieland D, Kriauciunas KM, Taub R
(1988) Nucleic Acids Res 16: 8204 - Insulin-receptor and apolipoprotein genes contribute to development of NIDDM in Chinese Americans.
Xiang KS, Cox NJ, Sanz N, Huang P, Karam JH, Bell GI
(1989) Diabetes 38: 17-23 - Bone formation is impaired in a model of type 1 diabetes.
Thrailkill KM, Liu L, Wahl EC, Bunn RC, Perrien DS, Cockrell GE, Skinner RA, Hogue WR, Carver AA, Fowlkes JL, Aronson J, Lumpkin CK
(2005) Diabetes 54: 2875-81 - Reversal of type 1 diabetes in mice by brown adipose tissue transplant.
Gunawardana SC, Piston DW
(2012) Diabetes 61: 674-82 - Regulation of Insulin Receptor Pathway and Glucose Metabolism by CD36 Signaling.
Samovski D, Dhule P, Pietka T, Jacome-Sosa M, Penrose E, Son NH, Flynn CR, Shoghi KI, Hyrc KL, Goldberg IJ, Gamazon ER, Abumrad NA
(2018) Diabetes 67: 1272-1284 - Linkage studies on NIDDM and the insulin and insulin-receptor genes.
Cox NJ, Epstein PA, Spielman RS
(1989) Diabetes 38: 653-8 - Global assessment of regulation of phosphorylation of insulin receptor substrate-1 by insulin in vivo in human muscle.
Yi Z, Langlais P, De Filippis EA, Luo M, Flynn CR, Schroeder S, Weintraub ST, Mapes R, Mandarino LJ
(2007) Diabetes 56: 1508-16 - Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets.
Kato T, Shimano H, Yamamoto T, Ishikawa M, Kumadaki S, Matsuzaka T, Nakagawa Y, Yahagi N, Nakakuki M, Hasty AH, Takeuchi Y, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Sone H, Yamada N
(2008) Diabetes 57: 2382-92 - 18FDG-PET predicts pharmacodynamic response to OSI-906, a dual IGF-1R/IR inhibitor, in preclinical mouse models of lung cancer.
McKinley ET, Bugaj JE, Zhao P, Guleryuz S, Mantis C, Gokhale PC, Wild R, Manning HC
(2011) Clin Cancer Res 17: 3332-40 - InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma.
Ma Y, Tang N, Thompson RC, Mobley BC, Clark SW, Sarkaria JN, Wang J
(2016) Clin Cancer Res 22: 1767-76
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.
