Telomere dysfunction induces metabolic and mitochondrial compromise. Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA (2011) Nature 470: 359-65 Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM (2001) Nature 413: 131-8 Control of pancreas and liver gene expression by HNF transcription factors. Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA (2004) Science 303: 1378-81 Dissecting the actions of widely used diabetes drugs. Unger RH, Berglund ED, Habener JF, Cherrington AD (2013) Nat Med 19: 272-3 Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Burgess SC, He T, Yan Z, Lindner J, Sherry AD, Malloy CR, Browning JD, Magnuson MA (2007) Cell Metab 5: 313-20 Sources of carbon for hepatic glycogen synthesis in the conscious dog. Moore MC, Cherrington AD, Cline G, Pagliassotti MJ, Jones EM, Neal DW, Badet C, Shulman GI (1991) J Clin Invest 88: 578-87 Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents. Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ (2009) J Clin Invest 119: 2577-89 Insulin's direct effects on the liver dominate the control of hepatic glucose production. Edgerton DS, Lautz M, Scott M, Everett CA, Stettler KM, Neal DW, Chu CA, Cherrington AD (2006) J Clin Invest 116: 521-7 Hepatic Gi signaling regulates whole-body glucose homeostasis. Rossi M, Zhu L, McMillin SM, Pydi SP, Jain S, Wang L, Cui Y, Lee RJ, Cohen AH, Kaneto H, Birnbaum MJ, Ma Y, Rotman Y, Liu J, Cyphert TJ, Finkel T, McGuinness OP, Wess J (2018) J Clin Invest 128: 746-759 Comparison of the direct and indirect effects of epinephrine on hepatic glucose production. Chu CA, Sindelar DK, Neal DW, Allen EJ, Donahue EP, Cherrington AD (1997) J Clin Invest 99: 1044-56 Insulin-induced hypoglycemia increases hepatic sensitivity to glucagon in dogs. Rivera N, Ramnanan CJ, An Z, Farmer T, Smith M, Farmer B, Irimia JM, Snead W, Lautz M, Roach PJ, Cherrington AD (2010) J Clin Invest 120: 4425-35 Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs. Ramnanan CJ, Saraswathi V, Smith MS, Donahue EP, Farmer B, Farmer TD, Neal D, Williams PE, Lautz M, Mari A, Cherrington AD, Edgerton DS (2011) J Clin Invest 121: 3713-23 Effect of glucagon on glucose production during insulin deficiency in the dog. Cherrington AD, Lacy WW, Chiasson JL (1978) J Clin Invest 62: 664-77 Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA, Wu H (2004) Proc Natl Acad Sci U S A 101: 2082-7 Defective glucose homeostasis during infection. McGuinness OP (2005) Annu Rev Nutr 25: 9-35 Relative importance of first- and second-phase insulin secretion in glucose homeostasis in conscious dog. II. Effects on gluconeogenesis. Steiner KE, Mouton SM, Williams PE, Lacy WW, Cherrington AD (1986) Diabetes 35: 776-84 The roles of insulin and glucagon in the regulation of gluconeogenesis in the postabsorptive dog. Jennings AS, Cherrington AD, Liljenquist JE, Keller U, Lacy WW, Chiasson JL (1977) Diabetes 26: 847-56 Altered ability of the liver to produce glucose following a period of glucagon deficiency. Deri JJ, Williams PE, Steiner KE, Cherrington AD (1981) Diabetes 30: 490-5 Similar dose responsiveness of hepatic glycogenolysis and gluconeogenesis to glucagon in vivo. Stevenson RW, Steiner KE, Davis MA, Hendrick GK, Williams PE, Lacy WW, Brown L, Donahue P, Lacy DB, Cherrington AD (1987) Diabetes 36: 382-9 Role of gluconeogenesis in sustaining glucose production during hypoglycemia caused by continuous insulin infusion in conscious dogs. Frizzell RT, Hendrick GK, Biggers DW, Lacy DB, Donahue DP, Green DR, Carr RK, Williams PE, Stevenson RW, Cherrington AD (1988) Diabetes 37: 749-59 Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo. Edgerton DS, Ramnanan CJ, Grueter CA, Johnson KM, Lautz M, Neal DW, Williams PE, Cherrington AD (2009) Diabetes 58: 2766-75 Alpha- and beta-cell responses to small changes in plasma glucose in the conscious dog. Flattem N, Igawa K, Shiota M, Emshwiller MG, Neal DW, Cherrington AD (2001) Diabetes 50: 367-75 Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo. Ramnanan CJ, Edgerton DS, Rivera N, Irimia-Dominguez J, Farmer B, Neal DW, Lautz M, Donahue EP, Meyer CM, Roach PJ, Cherrington AD (2010) Diabetes 59: 1302-11 Defective glycogenesis contributes toward the inability to suppress hepatic glucose production in response to hyperglycemia and hyperinsulinemia in zucker diabetic fatty rats. Torres TP, Fujimoto Y, Donahue EP, Printz RL, Houseknecht KL, Treadway JL, Shiota M (2011) Diabetes 60: 2225-33 Stimulation of glucose production through hormone secretion and other mechanisms during insulin-induced hypoglycemia. Frizzell RT, Hendrick GK, Brown LL, Lacy DB, Donahue EP, Carr RK, Williams PE, Parlow AF, Stevenson RW, Cherrington AD (1988) Diabetes 37: 1531-41 Effects of fasting on gluconeogenesis from alanine in nondiabetic man. Chiasson JL, Atkinson RL, Cherrington AD, Keller U, Sinclair-Smith BC, Lacy WW, Liljenquist JE (1979) Diabetes 28: 56-60 Effects of an acute increase in epinephrine and cortisol on carbohydrate metabolism during insulin deficiency. Goldstein RE, Abumrad NN, Lacy DB, Wasserman DH, Cherrington AD (1995) Diabetes 44: 672-81 Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism. Edgerton DS, Cardin S, Emshwiller M, Neal D, Chandramouli V, Schumann WC, Landau BR, Rossetti L, Cherrington AD (2001) Diabetes 50: 1872-82 Relationship between decrements in glucose level and metabolic response to hypoglycemia in absence of counterregulatory hormones in the conscious dog. Connolly CC, Adkins-Marshall BA, Neal DW, Pugh W, Jaspan JB, Cherrington AD (1992) Diabetes 41: 1308-19 Suppression of endogenous glucose production by mild hyperinsulinemia during exercise is determined predominantly by portal venous insulin. Camacho RC, Pencek RR, Lacy DB, James FD, Wasserman DH (2004) Diabetes 53: 285-93 Dichloroacetate--its in vivo effects on carbohydrate metabolism in the conscious dog. Diamond MP, Rollings RC, Erlendson L, Williams PE, Lacy WW, Rabin D, Cherrington AD (1980) Diabetes 29: 702-9 A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Sindelar DK, Balcom JH, Chu CA, Neal DW, Cherrington AD (1996) Diabetes 45: 1594-604 Differential time course of glucagon's effect on glycogenolysis and gluconeogenesis in the conscious dog. Cherrington AD, Williams PE, Shulman GI, Lacy WW (1981) Diabetes 30: 180-7 Effects of insulin deficiency or excess on hepatic gluconeogenic flux during glycogenolytic inhibition in the conscious dog. Edgerton DS, Cardin S, Pan C, Neal D, Farmer B, Converse M, Cherrington AD (2002) Diabetes 51: 3151-62 The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog. Sindelar DK, Chu CA, Rohlie M, Neal DW, Swift LL, Cherrington AD (1997) Diabetes 46: 187-96 Insulin sensitively controls the glucagon response to mild hypoglycemia in the dog. Igawa K, Mugavero M, Shiota M, Neal DW, Cherrington AD (2002) Diabetes 51: 3033-42 Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog. Shiota M, Moore MC, Galassetti P, Monohan M, Neal DW, Shulman GI, Cherrington AD (2002) Diabetes 51: 469-78 Role of glucagon suppression on gluconeogenesis during insulin treatment of the conscious diabetic dog. Stevenson RW, Williams PE, Cherrington AD (1987) Diabetologia 30: 782-90 Hypoxia-inducible factor 2 regulates hepatic lipid metabolism. Rankin EB, Rha J, Selak MA, Unger TL, Keith B, Liu Q, Haase VH (2009) Mol Cell Biol 29: 4527-38 Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. She P, Shiota M, Shelton KD, Chalkley R, Postic C, Magnuson MA (2000) Mol Cell Biol 20: 6508-17
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.