Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. Rice TW, Wheeler AP, Thompson BT, deBoisblanc BP, Steingrub J, Rock P, NIH NHLBI Acute Respiratory Distress Syndrome Network of Investigators, NHLBI ARDS Clinical Trials Network (2011) JAMA 306: 1574-81 The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Tager AM, LaCamera P, Shea BS, Campanella GS, Selman M, Zhao Z, Polosukhin V, Wain J, Karimi-Shah BA, Kim ND, Hart WK, Pardo A, Blackwell TS, Xu Y, Chun J, Luster AD (2008) Nat Med 14: 45-54 Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury. Volckaert T, Dill E, Campbell A, Tiozzo C, Majka S, Bellusci S, De Langhe SP (2011) J Clin Invest 121: 4409-19 β-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin. Tanjore H, Degryse AL, Crossno PF, Xu XC, McConaha ME, Jones BR, Polosukhin VV, Bryant AJ, Cheng DS, Newcomb DC, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE (2013) Am J Respir Crit Care Med 187: 630-9 Etanercept for treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation. Frangoul H, Koyama T, Domm J (2009) Blood 113: 2868-9; author reply 2869 Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress. Bastarache JA, Sebag SC, Clune JK, Grove BS, Lawson WE, Janz DR, Roberts LJ, Dworski R, Mackman N, Ware LB (2012) Thorax 67: 1032-9 The pathology of bleomycin-induced fibrosis is associated with loss of resident lung mesenchymal stem cells that regulate effector T-cell proliferation. Jun D, Garat C, West J, Thorn N, Chow K, Cleaver T, Sullivan T, Torchia EC, Childs C, Shade T, Tadjali M, Lara A, Nozik-Grayck E, Malkoski S, Sorrentino B, Meyrick B, Klemm D, Rojas M, Wagner DH, Majka SM (2011) Stem Cells 29: 725-35 Isofurans: novel products of lipid peroxidation that define the occurrence of oxidant injury in settings of elevated oxygen tension. Fessel JP, Jackson Roberts L (2005) Antioxid Redox Signal 7: 202-9 Acute lung injury: surprisingly common in the neurologic intensive care unit. Ware LB, Girard TD (2012) Crit Care Med 40: 694-5 Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome. O'Neal HR, Koyama T, Koehler EA, Siew E, Curtis BR, Fremont RD, May AK, Bernard GR, Ware LB (2011) Crit Care Med 39: 1343-50 Cecal ligation model of sepsis in mice: new insights. Bastarache JA, Matthay MA (2013) Crit Care Med 41: 356-7 Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Ware LB, Koyama T, Billheimer DD, Wu W, Bernard GR, Thompson BT, Brower RG, Standiford TJ, Martin TR, Matthay MA, NHLBI ARDS Clinical Trials Network (2010) Chest 137: 288-96 Innate immune function of the adherens junction protein p120-catenin in endothelial response to endotoxin. Wang YL, Malik AB, Sun Y, Hu S, Reynolds AB, Minshall RD, Hu G (2011) J Immunol 186: 3180-3187 Differential role for p120-catenin in regulation of TLR4 signaling in macrophages. Yang Z, Sun D, Yan Z, Reynolds AB, Christman JW, Minshall RD, Malik AB, Zhang Y, Hu G (2014) J Immunol 193: 1931-41 NADPH oxidase and Nrf2 regulate gastric aspiration-induced inflammation and acute lung injury. Davidson BA, Vethanayagam RR, Grimm MJ, Mullan BA, Raghavendran K, Blackwell TS, Freeman ML, Ayyasamy V, Singh KK, Sporn MB, Itagaki K, Hauser CJ, Knight PR, Segal BH (2013) J Immunol 190: 1714-24 Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury. Everhart MB, Han W, Sherrill TP, Arutiunov M, Polosukhin VV, Burke JR, Sadikot RT, Christman JW, Yull FE, Blackwell TS (2006) J Immunol 176: 4995-5005 IL-17A and TNF-α exert synergistic effects on expression of CXCL5 by alveolar type II cells in vivo and in vitro. Liu Y, Mei J, Gonzales L, Yang G, Dai N, Wang P, Zhang P, Favara M, Malcolm KC, Guttentag S, Worthen GS (2011) J Immunol 186: 3197-205 NADPH oxidase limits lipopolysaccharide-induced lung inflammation and injury in mice through reduction-oxidation regulation of NF-κB activity. Han W, Li H, Cai J, Gleaves LA, Polosukhin VV, Segal BH, Yull FE, Blackwell TS (2013) J Immunol 190: 4786-94 Acute lung injury but not sepsis is associated with increased colony formation by peripheral blood mononuclear cells. Burnham EL, Mealer M, Gaydos J, Majka S, Moss M (2010) Am J Respir Cell Mol Biol 43: 326-33 Hyperoxia synergizes with mutant bone morphogenic protein receptor 2 to cause metabolic stress, oxidant injury, and pulmonary hypertension. Fessel JP, Flynn CR, Robinson LJ, Penner NL, Gladson S, Kang CJ, Wasserman DH, Hemnes AR, West JD (2013) Am J Respir Cell Mol Biol 49: 778-87 Regulation of alveolar procoagulant activity and permeability in direct acute lung injury by lung epithelial tissue factor. Shaver CM, Grove BS, Putz ND, Clune JK, Lawson WE, Carnahan RH, Mackman N, Ware LB, Bastarache JA (2015) Am J Respir Cell Mol Biol 53: 719-27 Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury. Haeger SM, Liu X, Han X, McNeil JB, Oshima K, McMurtry SA, Yang Y, Ouyang Y, Zhang F, Nozik-Grayck E, Zemans RL, Tuder RM, Bastarache JA, Linhardt RJ, Schmidt EP (2018) Am J Respir Cell Mol Biol 59: 363-374 Successful Establishment of Primary Type II Alveolar Epithelium with 3D Organotypic Coculture. Sucre JMS, Jetter CS, Loomans H, Williams J, Plosa EJ, Benjamin JT, Young LR, Kropski JA, Calvi CL, Kook S, Wang P, Gleaves L, Eskaros A, Goetzl L, Blackwell TS, Guttentag SH, Zijlstra A (2018) Am J Respir Cell Mol Biol 59: 158-166 NF-κB inhibition after cecal ligation and puncture reduces sepsis-associated lung injury without altering bacterial host defense. Li H, Han W, Polosukhin V, Yull FE, Segal BH, Xie CM, Blackwell TS (2013) Mediators Inflamm 2013: 503213 Molecular targets for modulating lung inflammation and injury. Sadikot RT, Christman JW, Blackwell TS (2004) Curr Drug Targets 5: 581-8 Sepsis-induced acute lung injury (ALI) is milder in diabetic rats and correlates with impaired NFkB activation. Filgueiras LR, Martins JO, Serezani CH, Capelozzi VL, Montes MB, Jancar S (2012) PLoS One 7: e44987 Physiologic and pathologic alterations associated with ultrasonically generated shock waves. Hill DE, McDougal WS, Stephens H, Fogo A, Koch MO (1990) J Urol 144: 1531-4 TGFβ signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment. Degryse AL, Tanjore H, Xu XC, Polosukhin VV, Jones BR, Boomershine CS, Ortiz C, Sherrill TP, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE (2011) Am J Physiol Lung Cell Mol Physiol 300: L887-97 Cell-free hemoglobin: a novel mediator of acute lung injury. Shaver CM, Upchurch CP, Janz DR, Grove BS, Putz ND, Wickersham NE, Dikalov SI, Ware LB, Bastarache JA (2016) Am J Physiol Lung Cell Mol Physiol 310: L532-41 The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury. Zeyed YF, Bastarache JA, Matthay MA, Ware LB (2012) Am J Physiol Lung Cell Mol Physiol 303: L550-5 Endothelial-to-mesenchymal transition in lipopolysaccharide-induced acute lung injury drives a progenitor cell-like phenotype. Suzuki T, Tada Y, Nishimura R, Kawasaki T, Sekine A, Urushibara T, Kato F, Kinoshita T, Ikari J, West J, Tatsumi K (2016) Am J Physiol Lung Cell Mol Physiol 310: L1185-98 β-Catenin and CCNs in lung epithelial repair. Lawson WE, Blackwell TS (2013) Am J Physiol Lung Cell Mol Physiol 304: L579-81 The complex role of fibrin in acute lung injury. Bastarache JA (2009) Am J Physiol Lung Cell Mol Physiol 296: L275-6 PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression. Zhou W, Dowell DR, Geraci MW, Blackwell TS, Collins RD, Polosukhin VV, Lawson WE, Wu P, Sussan T, Biswal S, Goleniewska K, O'Neal J, Newcomb DC, Toki S, Morrow JD, Peebles RS (2011) Am J Physiol Lung Cell Mol Physiol 301: L615-22 Acute lung injury after hepatic cryoablation: correlation with NF-kappa B activation and cytokine production. Blackwell TS, Debelak JP, Venkatakrishnan A, Schot DJ, Harley DH, Pinson CW, Williams P, Washington K, Christman JW, Chapman WC (1999) Surgery 126: 518-26 Therapeutic modulation of coagulation and fibrinolysis in acute lung injury and the acute respiratory distress syndrome. Sebag SC, Bastarache JA, Ware LB (2011) Curr Pharm Biotechnol 12: 1481-96 Plasma biomarkers of oxidant stress and development of organ failure in severe sepsis. Ware LB, Fessel JP, May AK, Roberts LJ (2011) Shock 36: 12-7 Vitamin D and delirium in critically ill patients: a preliminary investigation. Morandi A, Barnett N, Miller RR, Girard TD, Pandharipande PP, Ely EW, Ware LB (2013) J Crit Care 28: 230-5 Alveolar fluid clearance is faster in women with acute lung injury compared to men. Bastarache JA, Ong T, Matthay MA, Ware LB (2011) J Crit Care 26: 249-56 A brief report: the use of high-frequency oscillatory ventilation for severe pulmonary contusion. Funk DJ, Lujan E, Moretti EW, Davies J, Young CC, Patel MB, Vaslef SN (2008) J Trauma 65: 390-5
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