The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151. Zijlstra A, Lewis J, Degryse B, Stuhlmann H, Quigley JP (2008) Cancer Cell 13: 221-34 Hold tight or you'll fall off: CD151 helps podocytes stick in high-pressure situations. Pozzi A, Zent R (2012) J Clin Invest 122: 13-6 TM4SF20 ancestral deletion and susceptibility to a pediatric disorder of early language delay and cerebral white matter hyperintensities. Wiszniewski W, Hunter JV, Hanchard NA, Willer JR, Shaw C, Tian Q, Illner A, Wang X, Cheung SW, Patel A, Campbell IM, Gelowani V, Hixson P, Ester AR, Azamian MS, Potocki L, Zapata G, Hernandez PP, Ramocki MB, Santos-Cortez RL, Wang G, York MK, Justice MJ, Chu ZD, Bader PI, Omo-Griffith L, Madduri NS, Scharer G, Crawford HP, Yanatatsaneejit P, Eifert A, Kerr J, Bacino CA, Franklin AI, Goin-Kochel RP, Simpson G, Immken L, Haque ME, Stosic M, Williams MD, Morgan TM, Pruthi S, Omary R, Boyadjiev SA, Win KK, Thida A, Hurles M, Hibberd ML, Khor CC, Van Vinh Chau N, Gallagher TE, Mutirangura A, Stankiewicz P, Beaudet AL, Maletic-Savatic M, Rosenfeld JA, Shaffer LG, Davis EE, Belmont JW, Dunstan S, Simmons CP, Bonnen PE, Leal SM, Katsanis N, Lupski JR, Lalani SR (2013) Am J Hum Genet 93: 197-210 Cortactin promotes exosome secretion by controlling branched actin dynamics. Sinha S, Hoshino D, Hong NH, Kirkbride KC, Grega-Larson NE, Seiki M, Tyska MJ, Weaver AM (2016) J Cell Biol 214: 197-213 Directional cell movement through tissues is controlled by exosome secretion. Sung BH, Ketova T, Hoshino D, Zijlstra A, Weaver AM (2015) Nat Commun 6: 7164 Human islets contain four distinct subtypes of β cells. Dorrell C, Schug J, Canaday PS, Russ HA, Tarlow BD, Grompe MT, Horton T, Hebrok M, Streeter PR, Kaestner KH, Grompe M (2016) Nat Commun 7: 11756 Integrin-free tetraspanin CD151 can inhibit tumor cell motility upon clustering and is a clinical indicator of prostate cancer progression. Palmer TD, Martínez CH, Vasquez C, Hebron KE, Jones-Paris C, Arnold SA, Chan SM, Chalasani V, Gomez-Lemus JA, Williams AK, Chin JL, Giannico GA, Ketova T, Lewis JD, Zijlstra A (2014) Cancer Res 74: 173-87 Coexpression of CD9 augments the ability of membrane-bound heparin-binding epidermal growth factor-like growth factor (proHB-EGF) to preserve renal epithelial cell viability. Takemura T, Hino S, Murata Y, Yanagida H, Okada M, Yoshioka K, Harris RC (1999) Kidney Int 55: 71-81 NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (1997) J Biol Chem 272: 29181-9 Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins). Berditchevski F, Zutter MM, Hemler ME (1996) Mol Biol Cell 7: 193-207 Integrin alpha 6A beta 1 induces CD81-dependent cell motility without engaging the extracellular matrix migration substrate. Domanico SZ, Pelletier AJ, Havran WL, Quaranta V (1997) Mol Biol Cell 8: 2253-65 The Ste20 kinases SPAK and OSR1 travel between cells through exosomes. Koumangoye R, Delpire E (2016) Am J Physiol Cell Physiol 311: C43-53 Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance. Singh AB, Sugimoto K, Dhawan P, Harris RC (2007) Am J Physiol Cell Physiol 293: C1660-8 Exosome secretion is enhanced by invadopodia and drives invasive behavior. Hoshino D, Kirkbride KC, Costello K, Clark ES, Sinha S, Grega-Larson N, Tyska MJ, Weaver AM (2013) Cell Rep 5: 1159-68
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.