Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. Muraoka RS, Dumont N, Ritter CA, Dugger TC, Brantley DM, Chen J, Easterly E, Roebuck LR, Ryan S, Gotwals PJ, Koteliansky V, Arteaga CL (2002) J Clin Invest 109: 1551-9 Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells. Guney MA, Petersen CP, Boustani A, Duncan MR, Gunasekaran U, Menon R, Warfield C, Grotendorst GR, Means AL, Economides AN, Gannon M (2011) Proc Natl Acad Sci U S A 108: 15242-7 Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon. Clark ES, Brown B, Whigham AS, Kochaishvili A, Yarbrough WG, Weaver AM (2009) Oncogene 28: 431-44 MGSA/GRO-mediated melanocyte transformation involves induction of Ras expression. Wang D, Yang W, Du J, Devalaraja MN, Liang P, Matsumoto K, Tsubakimoto K, Endo T, Richmond A (2000) Oncogene 19: 4647-59 BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma. Loganathan SN, Tang N, Fleming JT, Ma Y, Guo Y, Borinstein SC, Chiang C, Wang J (2016) Oncotarget 7: 43504-43517 Loss of annexin A1 disrupts normal prostate glandular structure by inducing autocrine IL-6 signaling. Inokuchi J, Lau A, Tyson DR, Ornstein DK (2009) Carcinogenesis 30: 1082-8 mPGES1-Dependent Prostaglandin E (PGE) Controls Antigen-Specific Th17 and Th1 Responses by Regulating T Autocrine and Paracrine PGE Production. Maseda D, Johnson EM, Nyhoff LE, Baron B, Kojima F, Wilhelm AJ, Ward MR, Woodward JG, Brand DD, Crofford LJ (2018) J Immunol 200: 725-736 Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis. Damstrup L, Kuwada SK, Dempsey PJ, Brown CL, Hawkey CJ, Poulsen HS, Wiley HS, Coffey RJ (1999) Br J Cancer 80: 1012-9 Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta. Shiou SR, Datta PK, Dhawan P, Law BK, Yingling JM, Dixon DA, Beauchamp RD (2006) J Biol Chem 281: 33971-81 Loss of the polarity protein PAR3 activates STAT3 signaling via an atypical protein kinase C (aPKC)/NF-κB/interleukin-6 (IL-6) axis in mouse mammary cells. Guyer RA, Macara IG (2015) J Biol Chem 290: 8457-68 Bves and NDRG4 regulate directional epicardial cell migration through autocrine extracellular matrix deposition. Benesh EC, Miller PM, Pfaltzgraff ER, Grega-Larson NE, Hager HA, Sung BH, Qu X, Baldwin HS, Weaver AM, Bader DM (2013) Mol Biol Cell 24: 3496-510 Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer. Stoeltzing O, Liu W, Reinmuth N, Fan F, Parikh AA, Bucana CD, Evans DB, Semenza GL, Ellis LM (2003) Am J Pathol 163: 1001-11 Autocrine VEGF/VEGFR1 signaling in a subpopulation of cells associates with aggressive osteosarcoma. Ohba T, Cates JM, Cole HA, Slosky DA, Haro H, Ando T, Schwartz HS, Schoenecker JG (2014) Mol Cancer Res 12: 1100-11 Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Singh AB, Harris RC (2005) Cell Signal 17: 1183-93 Inhibition of transforming growth factor alpha stimulation of human squamous cell carcinoma of the head and neck with anti-TGF-alpha antibodies and tyrphostin. Solorzano CC, Jones SC, Pettitjean M, O'Daniel TG, Auffenberg T, Woost PG, Copeland EM, Moldawer LL, Schultz GS, MacKay SL (1997) Ann Surg Oncol 4: 670-84 Autocrine regulation of norepinephrine transporter expression. Ren ZG, Pörzgen P, Zhang JM, Chen XR, Amara SG, Blakely RD, Sieber-Blum M (2001) Mol Cell Neurosci 17: 539-50 Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance. Singh AB, Sugimoto K, Dhawan P, Harris RC (2007) Am J Physiol Cell Physiol 293: C1660-8 ApoE-mediated cholesterol efflux from macrophages: separation of autocrine and paracrine effects. Dove DE, Linton MF, Fazio S (2005) Am J Physiol Cell Physiol 288: C586-92 Smad7 inhibits autocrine expression of TGF-β2 in intestinal epithelial cells in baboon necrotizing enterocolitis. Namachivayam K, Blanco CL, MohanKumar K, Jagadeeswaran R, Vasquez M, McGill-Vargas L, Garzon SA, Jain SK, Gill RK, Freitag NE, Weitkamp JH, Seidner SR, Maheshwari A (2013) Am J Physiol Gastrointest Liver Physiol 304: G167-80 Voltage-dependent, pertussis toxin insensitive inhibition of calcium currents by histamine in bovine adrenal chromaffin cells. Currie KP, Fox AP (2000) J Neurophysiol 83: 1435-42 Regulation of T-cell function by endogenously produced angiotensin II. Hoch NE, Guzik TJ, Chen W, Deans T, Maalouf SA, Gratze P, Weyand C, Harrison DG (2009) Am J Physiol Regul Integr Comp Physiol 296: R208-16 Apoptotic cells selectively suppress the Th1 cytokine interferon gamma in stimulated human peripheral blood mononuclear cells and shift the Th1/Th2 balance towards Th2. Girkontaite I, Urbonaviciute V, Maseda D, Neubert K, Herrmann M, Voll RE (2007) Autoimmunity 40: 327-30 Induction of podocyte-derived VEGF ameliorates podocyte injury and subsequent abnormal glomerular development caused by puromycin aminonucleoside. Ma J, Matsusaka T, Yang HC, Zhong J, Takagi N, Fogo AB, Kon V, Ichikawa I (2011) Pediatr Res 70: 83-9
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.