Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Rickert RC, Rajewsky K, Roes J (1995) Nature 376: 352-5 Proteasome inhibition drastically but reversibly impairs murine lymphocyte development. Maseda D, Meister S, Neubert K, Herrmann M, Voll RE (2008) Cell Death Differ 15: 600-12 Somatically mutated B cell pool provides precursors for insulin antibodies. Thomas JW, Hulbert C (1996) J Immunol 157: 763-71 T cell-independent response to Brucella-insulin identifies a preimmune repertoire for insulin. Thomas JW, Kralick PM, Ewulonu UK (1997) J Immunol 159: 2334-41 Bruton's Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages. Nyhoff LE, Clark ES, Barron BL, Bonami RH, Khan WN, Kendall PL (2018) J Immunol 200: 2352-2361 Immunodominance of the VH1-46 antibody gene segment in the primary repertoire of human rotavirus-specific B cells is reduced in the memory compartment through somatic mutation of nondominant clones. Tian C, Luskin GK, Dischert KM, Higginbotham JN, Shepherd BE, Crowe JE (2008) J Immunol 180: 3279-88 Tolerant anti-insulin B cells are effective APCs. Kendall PL, Case JB, Sullivan AM, Holderness JS, Wells KS, Liu E, Thomas JW (2013) J Immunol 190: 2519-26 Microarray analysis of Lyn-deficient B cells reveals germinal center-associated nuclear protein and other genes associated with the lymphoid germinal center. Mirnics ZK, Caudell E, Gao Y, Kuwahara K, Sakaguchi N, Kurosaki T, Burnside J, Mirnics K, Corey SJ (2004) J Immunol 172: 4133-41 CpG DNA induces a class II transactivator-independent increase in class II MHC by stabilizing class II MHC mRNA in B lymphocytes. Kuchtey J, Pennini M, Pai RK, Harding CV (2003) J Immunol 171: 2320-5 Infant and adult human B cell responses to rotavirus share common immunodominant variable gene repertoires. Weitkamp JH, Kallewaard N, Kusuhara K, Bures E, Williams JV, LaFleur B, Greenberg HB, Crowe JE (2003) J Immunol 171: 4680-8 Helicobacter pylori vacuolating cytotoxin inhibits activation-induced proliferation of human T and B lymphocyte subsets. Torres VJ, VanCompernolle SE, Sundrud MS, Unutmaz D, Cover TL (2007) J Immunol 179: 5433-40 Cutting edge: transplant tolerance induced by anti-CD45RB requires B lymphocytes. Deng S, Moore DJ, Huang X, Lian MM, Mohiuddin M, Velededeoglu E, Lee MK, Sonawane S, Kim J, Wang J, Chen H, Corfe SA, Paige C, Shlomchik M, Caton A, Markmann JF (2007) J Immunol 178: 6028-32 Bruton's Tyrosine Kinase Synergizes with Notch2 To Govern Marginal Zone B Cells in Nonobese Diabetic Mice. Case JB, Bonami RH, Nyhoff LE, Steinberg HE, Sullivan AM, Kendall PL (2015) J Immunol 195: 61-70 Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B Cells. Polikowsky HG, Wogsland CE, Diggins KE, Huse K, Irish JM (2015) J Immunol 195: 1364-1367 Anti-Insulin B Cells Are Poised for Antigen Presentation in Type 1 Diabetes. Felton JL, Maseda D, Bonami RH, Hulbert C, Thomas JW (2018) J Immunol 201: 861-873 Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry. Irish JM, Czerwinski DK, Nolan GP, Levy R (2006) J Immunol 177: 1581-9 Anergy and not clonal ignorance determines the fate of B cells that recognize a physiological autoantigen. Rojas M, Hulbert C, Thomas JW (2001) J Immunol 166: 3194-200 Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis. Yang JQ, Singh AK, Wilson MT, Satoh M, Stanic AK, Park JJ, Hong S, Gadola SD, Mizutani A, Kakumanu SR, Reeves WH, Cerundolo V, Joyce S, Van Kaer L, Singh RR (2003) J Immunol 171: 2142-53 Uncoupling of anergy from developmental arrest in anti-insulin B cells supports the development of autoimmune diabetes. Acevedo-Suárez CA, Hulbert C, Woodward EJ, Thomas JW (2005) J Immunol 174: 827-33 Multiple germline kappa light chains generate anti-insulin B cells in nonobese diabetic mice. Woodward EJ, Thomas JW (2005) J Immunol 175: 1073-9 Impaired intracellular calcium mobilization and NFATc1 availability in tolerant anti-insulin B cells. Acevedo-Suárez CA, Kilkenny DM, Reich MB, Thomas JW (2006) J Immunol 177: 2234-41 Reduced diabetes in btk-deficient nonobese diabetic mice and restoration of diabetes with provision of an anti-insulin IgH chain transgene. Kendall PL, Moore DJ, Hulbert C, Hoek KL, Khan WN, Thomas JW (2009) J Immunol 183: 6403-12 Regulation of gastric B cell recruitment is dependent on IL-17 receptor A signaling in a model of chronic bacterial infection. Algood HM, Allen SS, Washington MK, Peek RM, Miller GG, Cover TL (2009) J Immunol 183: 5837-46 CXCL13 blockade disrupts B lymphocyte organization in tertiary lymphoid structures without altering B cell receptor bias or preventing diabetes in nonobese diabetic mice. Henry RA, Kendall PL (2010) J Immunol 185: 1460-5 Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo. Maseda D, Smith SH, DiLillo DJ, Bryant JM, Candando KM, Weaver CT, Tedder TF (2012) J Immunol 188: 1036-48 Expression of cyclooxygenase-2 and prostaglandins by B-1 cells and B-CLL cells. Phipps RP, Pollock SJ, Kaur K, Kaufman J, Borrello MA, Graf BA, Nazarenko D, Roberts LJ, Morrow JD, Palis J, Ryan DJ, Bennett JM (2000) Curr Top Microbiol Immunol 252: 293-300 Expression and regulation of clonally ignorant B cells. Thomas JW, Hulbert C (1995) Ann N Y Acad Sci 764: 461-2 Induction of immune tolerance to a transplantation carbohydrate antigen by gene therapy with autologous lymphocytes transduced with adenovirus containing the corresponding glycosyltransferase gene. Ogawa H, Yin DP, Galili U (2004) Gene Ther 11: 292-301 Immature B Cell Egress from Bone Marrow Is SOCS3 Independent. Nadrah K, Beck TC, Pereira JP (2015) PLoS One 10: e0136061 High-throughput antibody sequencing reveals genetic evidence of global regulation of the naïve and memory repertoires that extends across individuals. Briney BS, Willis JR, McKinney BA, Crowe JE (2012) Genes Immun 13: 469-73 Antigen-specific responses in autoimmunity and tolerance. Thomas JW (2001) Immunol Res 23: 235-44 Regulation of B lymphocytes and plasma cells by innate immune mechanisms and stromal cells in rheumatoid arthritis. Maseda D, Bonami RH, Crofford LJ (2014) Expert Rev Clin Immunol 10: 747-62 NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. Bonami RH, Wolfle WT, Thomas JW, Kendall PL (2014) Mol Immunol 62: 321-8 An intact NF-kappa B signaling pathway is required for maintenance of mature B cell subsets. Bendall HH, Sikes ML, Ballard DW, Oltz EM (1999) Mol Immunol 36: 187-95 Rotavirus-specific CD5+ B cells in young children exhibit a distinct antibody repertoire compared with CD5- B cells. Weitkamp JH, Lafleur BJ, Crowe JE (2006) Hum Immunol 67: 33-42
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.