Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia. Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, Young SG (2017) N Engl J Med 376: 1647-1658 Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y (2006) Science 312: 1656-9 Beta-adrenergic receptors and regulation of energy expenditure: a family affair. Robidoux J, Martin TL, Collins S (2004) Annu Rev Pharmacol Toxicol 44: 297-323 Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis. Albaugh VL, Judson JG, She P, Lang CH, Maresca KP, Joyal JL, Lynch CJ (2011) Mol Psychiatry 16: 569-81 Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension. Hemnes AR, Brittain EL, Trammell AW, Fessel JP, Austin ED, Penner N, Maynard KB, Gleaves L, Talati M, Absi T, Disalvo T, West J (2014) Am J Respir Crit Care Med 189: 325-34 Melanocortin-3 receptor regulates the normal fasting response. Renquist BJ, Murphy JG, Larson EA, Olsen D, Klein RF, Ellacott KL, Cone RD (2012) Proc Natl Acad Sci U S A 109: E1489-98 Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes. Imai T, Jiang M, Chambon P, Metzger D (2001) Proc Natl Acad Sci U S A 98: 224-8 Atypical antipsychotics rapidly and inappropriately switch peripheral fuel utilization to lipids, impairing metabolic flexibility in rodents. Albaugh VL, Vary TC, Ilkayeva O, Wenner BR, Maresca KP, Joyal JL, Breazeale S, Elich TD, Lang CH, Lynch CJ (2012) Schizophr Bull 38: 153-66 Targeted disruption of G0/G1 switch gene 2 enhances adipose lipolysis, alters hepatic energy balance, and alleviates high-fat diet-induced liver steatosis. Zhang X, Xie X, Heckmann BL, Saarinen AM, Czyzyk TA, Liu J (2014) Diabetes 63: 934-46 Changes in glucose and fat metabolism in response to the administration of a hepato-preferential insulin analog. Edgerton DS, Moore MC, Winnick JJ, Scott M, Farmer B, Naver H, Jeppesen CB, Madsen P, Kjeldsen TB, Nishimura E, Brand CL, Cherrington AD (2014) Diabetes 63: 3946-54 Regulation of ketogenesis by epinephrine and norepinephrine in the overnight-fasted, conscious dog. Steiner KE, Fuchs H, Williams PE, Stevenson RW, Cherrington AD, Alberti KG (1985) Diabetes 34: 425-32 CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action. Lord CC, Betters JL, Ivanova PT, Milne SB, Myers DS, Madenspacher J, Thomas G, Chung S, Liu M, Davis MA, Lee RG, Crooke RM, Graham MJ, Parks JS, Brasaemle DL, Fessler MB, Brown HA, Brown JM (2012) Diabetes 61: 355-63 Effects of Antecedent GABA A Receptor Activation on Counterregulatory Responses to Exercise in Healthy Man. Hedrington MS, Tate DB, Younk LM, Davis SN (2015) Diabetes 64: 3253-61 A compendium of G-protein-coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure. Ceddia RP, Collins S (2020) Clin Sci (Lond) 134: 473-512 Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism. Collins S, Cao W, Robidoux J (2004) Mol Endocrinol 18: 2123-31 Chronic ethanol feeding suppresses beta-adrenergic receptor-stimulated lipolysis in adipocytes isolated from epididymal fat. Kang L, Nagy LE (2006) Endocrinology 147: 4330-8 Inhibition of cisplatin-induced lipid catabolism and weight loss by ghrelin in male mice. Garcia JM, Scherer T, Chen JA, Guillory B, Nassif A, Papusha V, Smiechowska J, Asnicar M, Buettner C, Smith RG (2013) Endocrinology 154: 3118-29 Maximal beta3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation. Robidoux J, Kumar N, Daniel KW, Moukdar F, Cyr M, Medvedev AV, Collins S (2006) J Biol Chem 281: 37794-802 Chronic ethanol and triglyceride turnover in white adipose tissue in rats: inhibition of the anti-lipolytic action of insulin after chronic ethanol contributes to increased triglyceride degradation. Kang L, Chen X, Sebastian BM, Pratt BT, Bederman IR, Alexander JC, Previs SF, Nagy LE (2007) J Biol Chem 282: 28465-28473 Insulin antagonism of catecholamine stimulation of fatty acid transport in the adipocyte. Studies on its mechanism of action. Abumrad NA, Harmon CM, Barnela US, Whitesell RR (1988) J Biol Chem 263: 14678-83 The role of adipose tissue in mediating the beneficial effects of dietary fish oil. Puglisi MJ, Hasty AH, Saraswathi V (2011) J Nutr Biochem 22: 101-8 Atherosclerotic lesion formation and triglyceride storage in obese apolipoprotein AI-deficient mice. Plummer MR, Hasty AH (2008) J Nutr Biochem 19: 664-73 Involvement of the vagus nerves in the regulation of basal hepatic glucose production in conscious dogs. Cardin S, Walmsley K, Neal DW, Williams PE, Cherrington AD (2002) Am J Physiol Endocrinol Metab 283: E958-64 Alterations in basal glucose metabolism during late pregnancy in the conscious dog. Connolly CC, Holste LC, Aglione LN, Neal DW, Lacy DB, Smith MS, Diamond MP, Cherrington AD, Chiasson JL (2000) Am J Physiol Endocrinol Metab 279: E1166-77 Insulin action during late pregnancy in the conscious dog. Connolly CC, Aglione LN, Smith MS, Lacy DB, Moore MC (2004) Am J Physiol Endocrinol Metab 286: E909-15 The role of lipolysis in mediating the proinflammatory effects of very low density lipoproteins in mouse peritoneal macrophages. Saraswathi V, Hasty AH (2006) J Lipid Res 47: 1406-15 LXRα fuels fatty acid-stimulated oxygen consumption in white adipocytes. Dib L, Bugge A, Collins S (2014) J Lipid Res 55: 247-57 Phosphoenolpyruvate carboxykinase (Pck1) helps regulate the triglyceride/fatty acid cycle and development of insulin resistance in mice. Millward CA, Desantis D, Hsieh CW, Heaney JD, Pisano S, Olswang Y, Reshef L, Beidelschies M, Puchowicz M, Croniger CM (2010) J Lipid Res 51: 1452-63 Modulation of adipocyte biology by δ(9)-tetrahydrocannabinol. Teixeira D, Pestana D, Faria A, Calhau C, Azevedo I, Monteiro R (2010) Obesity (Silver Spring) 18: 2077-85 Effect of hyperglycemia independent of changes in insulin or glucagon on lipolysis in the conscious dog. Shulman GI, Williams PE, Liljenquist JE, Lacy WW, Keller U, Cherrington AD (1980) Metabolism 29: 317-20 The effects of epinephrine on ketogenesis in the dog after a prolonged fast. Steiner KE, Stevenson RW, Adkins-Marshall BA, Cherrington AD (1991) Metabolism 40: 1057-62 Insulin action on the liver in vivo. Cherrington AD, Moore MC, Sindelar DK, Edgerton DS (2007) Biochem Soc Trans 35: 1171-4 Developmental, hormonal, and nutritional regulation of porcine adipose triglyceride lipase (ATGL). Deiuliis JA, Shin J, Bae D, Azain MJ, Barb R, Lee K (2008) Lipids 43: 215-25 Dichloroacetate: direct inhibitor of lipolysis in the conscious dog. Diamond MP, Suhrer JH, Williams PE, Cherrington AD (1982) Horm Metab Res 14: 102-3 Lysosomal hydrolysis of lipids in a cell culture model of smooth muscle foam cells. Minor LK, Mahlberg FH, Jerome WG, Lewis JC, Rothblat GH, Glick JM (1991) Exp Mol Pathol 54: 159-71
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