Nitric oxide modulates bacterial biofilm formation through a multicomponent cyclic-di-GMP signaling network. Plate L, Marletta MA (2012) Mol Cell 46: 449-60 Relationship of adenosine 3',5'-cyclic monophosphate and guanosine 3',5'-cyclic monophosphate to growth of dimethylbenz(a)anthracene-induced mammary tumors in rats. Matusik RJ, Hilf R (1976) J Natl Cancer Inst 56: 659-61 Atrial natriuretic peptide is negatively regulated by microRNA-425. Arora P, Wu C, Khan AM, Bloch DB, Davis-Dusenbery BN, Ghorbani A, Spagnolli E, Martinez A, Ryan A, Tainsh LT, Kim S, Rong J, Huan T, Freedman JE, Levy D, Miller KK, Hata A, Del Monte F, Vandenwijngaert S, Swinnen M, Janssens S, Holmes TM, Buys ES, Bloch KD, Newton-Cheh C, Wang TJ (2013) J Clin Invest 123: 3378-82 cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism. Takimoto E, Champion HC, Belardi D, Moslehi J, Mongillo M, Mergia E, Montrose DC, Isoda T, Aufiero K, Zaccolo M, Dostmann WR, Smith CJ, Kass DA (2005) Circ Res 96: 100-9 Nitrite therapy improves left ventricular function during heart failure via restoration of nitric oxide-mediated cytoprotective signaling. Bhushan S, Kondo K, Polhemus DJ, Otsuka H, Nicholson CK, Tao YX, Huang H, Georgiopoulou VV, Murohara T, Calvert JW, Butler J, Lefer DJ (2014) Circ Res 114: 1281-91 Identification of key factors that reduce the variability of the single photon response. Caruso G, Bisegna P, Andreucci D, Lenoci L, Gurevich VV, Hamm HE, DiBenedetto E (2011) Proc Natl Acad Sci U S A 108: 7804-7 Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase. Prasad HC, Zhu CB, McCauley JL, Samuvel DJ, Ramamoorthy S, Shelton RC, Hewlett WA, Sutcliffe JS, Blakely RD (2005) Proc Natl Acad Sci U S A 102: 11545-50 Elevated plasma and urinary guanosine 3':5'-monophosphate and increased production rate in patients with neoplastic diseases. Chawla RK, Shlaer SM, Lawson DH, Murray TG, Schmidt F, Shoji M, Nixon DW, Richmond A, Rudman D (1980) Cancer Res 40: 3915-20 Dietary fatty acid modulates glomerular atrial natriuretic peptide receptor. Awazu M, Yared A, Swift LL, Hoover RL, Ichikawa I (1992) Kidney Int 42: 265-71 A cyclic guanosine monophosphate-dependent pathway can regulate net hepatic glucose uptake in vivo. An Z, Winnick JJ, Moore MC, Farmer B, Smith M, Irimia JM, Roach PJ, Cherrington AD (2012) Diabetes 61: 2433-41 Modulation of thalamocortical oscillations by TRIP8b, an auxiliary subunit for HCN channels. Zobeiri M, Chaudhary R, Datunashvili M, Heuermann RJ, Lüttjohann A, Narayanan V, Balfanz S, Meuth P, Chetkovich DM, Pape HC, Baumann A, van Luijtelaar G, Budde T (2018) Brain Struct Funct 223: 1537-1564 Single molecule analysis of serotonin transporter regulation using antagonist-conjugated quantum dots reveals restricted, p38 MAPK-dependent mobilization underlying uptake activation. Chang JC, Tomlinson ID, Warnement MR, Ustione A, Carneiro AM, Piston DW, Blakely RD, Rosenthal SJ (2012) J Neurosci 32: 8919-29 Pleiotropic regulation of vascular smooth muscle tone by cyclic GMP-dependent protein kinase. Lincoln TM, Komalavilas P, Cornwell TL (1994) Hypertension 23: 1141-7 The effects of tadalafil on cold-induced vasoconstriction in patients with Raynaud's phenomenon. Friedman EA, Harris PA, Wood AJ, Stein CM, Kurnik D (2007) Clin Pharmacol Ther 81: 503-9 Enhanced activity of human serotonin transporter variants associated with autism. Prasad HC, Steiner JA, Sutcliffe JS, Blakely RD (2009) Philos Trans R Soc Lond B Biol Sci 364: 163-73 Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Becker JR, Chatterjee S, Robinson TY, Bennett JS, Panáková D, Galindo CL, Zhong L, Shin JT, Coy SM, Kelly AE, Roden DM, Lim CC, MacRae CA (2014) Development 141: 335-45 Role of adenosine and nitric oxide on the mechanisms of action of dipyridamole. Gamboa A, Abraham R, Diedrich A, Shibao C, Paranjape SY, Farley G, Biaggioni I (2005) Stroke 36: 2170-5 Effects of indomethacin on cyclic nucleotide levels and histamine release from rat serosal mast cells. Lewis RA, Holgate ST, Roberts LJ, Maguire JF, Oates JA, Austen KF (1979) J Immunol 123: 1663-8 Evidence that additional mechanisms to cyclic GMP mediate the decrease in intracellular calcium and relaxation of rabbit aortic smooth muscle to nitric oxide. Weisbrod RM, Griswold MC, Yaghoubi M, Komalavilas P, Lincoln TM, Cohen RA (1998) Br J Pharmacol 125: 1695-707 Prolactin regulation of casein gene expression: possible mediators. Matusik RJ, Rosen JM (1980) Endocrinology 106: 252-9 Phosphorylation of the inositol 1,4,5-trisphosphate receptor. Cyclic GMP-dependent protein kinase mediates cAMP and cGMP dependent phosphorylation in the intact rat aorta. Komalavilas P, Lincoln TM (1996) J Biol Chem 271: 21933-8 Subunit structure of rod cGMP-phosphodiesterase. Artemyev NO, Surendran R, Lee JC, Hamm HE (1996) J Biol Chem 271: 25382-8 Regulation of transducin GTPase activity in bovine rod outer segments. Arshavsky VY, Dumke CL, Zhu Y, Artemyev NO, Skiba NP, Hamm HE, Bownds MD (1994) J Biol Chem 269: 19882-7 Mechanism of action of monoclonal antibodies that block the light activation of the guanyl nucleotide-binding protein, transducin. Hamm HE, Deretic D, Hofmann KP, Schleicher A, Kohl B (1987) J Biol Chem 262: 10831-8 A monoclonal antibody against the rod outer segment guanyl nucleotide-binding protein, transducin, blocks the stimulatory and inhibitory G proteins of adenylate cyclase. Hamm HE, Deretic D, Mazzoni MR, Moore CA, Takahashi JS, Rasenick MM (1989) J Biol Chem 264: 11475-82 Sites of interaction between rod G-protein alpha-subunit and cGMP-phosphodiesterase gamma-subunit. Implications for the phosphodiesterase activation mechanism. Artemyev NO, Rarick HM, Mills JS, Skiba NP, Hamm HE (1992) J Biol Chem 267: 25067-72 The carboxyl terminus of the gamma-subunit of rod cGMP phosphodiesterase contains distinct sites of interaction with the enzyme catalytic subunits and the alpha-subunit of transducin. Skiba NP, Artemyev NO, Hamm HE (1995) J Biol Chem 270: 13210-5 Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells. Komalavilas P, Shah PK, Jo H, Lincoln TM (1999) J Biol Chem 274: 34301-9 Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase. Komalavilas P, Lincoln TM (1994) J Biol Chem 269: 8701-7 A site on transducin alpha-subunit of interaction with the polycationic region of cGMP phosphodiesterase inhibitory subunit. Artemyev NO, Mills JS, Thornburg KR, Knapp DR, Schey KL, Hamm HE (1993) J Biol Chem 268: 23611-5 Role of the small heat shock proteins in regulating vascular smooth muscle tone. McLemore EC, Tessier DJ, Thresher J, Komalavilas P, Brophy CM (2005) J Am Coll Surg 201: 30-6 Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation. Zhu CB, Hewlett WA, Feoktistov I, Biaggioni I, Blakely RD (2004) Mol Pharmacol 65: 1462-74
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