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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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- Improved survival with ipilimumab in patients with metastatic melanoma.
Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel JC, Akerley W, van den Eertwegh AJ, Lutzky J, Lorigan P, Vaubel JM, Linette GP, Hogg D, Ottensmeier CH, Lebbé C, Peschel C, Quirt I, Clark JI, Wolchok JD, Weber JS, Tian J, Yellin MJ, Nichol GM, Hoos A, Urba WJ
(2010) N Engl J Med 363: 711-23 - NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain.
Huang B, Eberstadt M, Olejniczak ET, Meadows RP, Fesik SW
(1996) Nature 384: 638-41 - Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.
Rickert RC, Rajewsky K, Roes J
(1995) Nature 376: 352-5 - Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis.
Yin XM, Wang K, Gross A, Zhao Y, Zinkel S, Klocke B, Roth KA, Korsmeyer SJ
(1999) Nature 400: 886-91 - Mox2 is a component of the genetic hierarchy controlling limb muscle development.
Mankoo BS, Collins NS, Ashby P, Grigorieva E, Pevny LH, Candia A, Wright CV, Rigby PW, Pachnis V
(1999) Nature 400: 69-73 - Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells.
Kelly OG, Chan MY, Martinson LA, Kadoya K, Ostertag TM, Ross KG, Richardson M, Carpenter MK, D'Amour KA, Kroon E, Moorman M, Baetge EE, Bang AG
(2011) Nat Biotechnol 29: 750-6 - NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines.
van Montfoort N, Borst L, Korrer MJ, Sluijter M, Marijt KA, Santegoets SJ, van Ham VJ, Ehsan I, Charoentong P, André P, Wagtmann N, Welters MJP, Kim YJ, Piersma SJ, van der Burg SH, van Hall T
(2018) Cell 175: 1744-1755.e15 - Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.
Ciriello G, Gatza ML, Beck AH, Wilkerson MD, Rhie SK, Pastore A, Zhang H, McLellan M, Yau C, Kandoth C, Bowlby R, Shen H, Hayat S, Fieldhouse R, Lester SC, Tse GM, Factor RE, Collins LC, Allison KH, Chen YY, Jensen K, Johnson NB, Oesterreich S, Mills GB, Cherniack AD, Robertson G, Benz C, Sander C, Laird PW, Hoadley KA, King TA, TCGA Research Network, Perou CM
(2015) Cell 163: 506-19 - Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation.
Lau KS, Partridge EA, Grigorian A, Silvescu CI, Reinhold VN, Demetriou M, Dennis JW
(2007) Cell 129: 123-34 - SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages.
Berger SB, Romero X, Ma C, Wang G, Faubion WA, Liao G, Compeer E, Keszei M, Rameh L, Wang N, Boes M, Regueiro JR, Reinecker HC, Terhorst C
(2010) Nat Immunol 11: 920-7 - Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence.
Zhang B, Beeghly-Fadiel A, Long J, Zheng W
(2011) Lancet Oncol 12: 477-88 - The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151.
Zijlstra A, Lewis J, Degryse B, Stuhlmann H, Quigley JP
(2008) Cancer Cell 13: 221-34 - The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia.
Linggi B, Müller-Tidow C, van de Locht L, Hu M, Nip J, Serve H, Berdel WE, van der Reijden B, Quelle DE, Rowley JD, Cleveland J, Jansen JH, Pandolfi PP, Hiebert SW
(2002) Nat Med 8: 743-50 - CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection.
Motsinger A, Haas DW, Stanic AK, Van Kaer L, Joyce S, Unutmaz D
(2002) J Exp Med 195: 869-79 - Distinct roles for signals relayed through the common cytokine receptor gamma chain and interleukin 7 receptor alpha chain in natural T cell development.
Boesteanu A, Silva AD, Nakajima H, Leonard WJ, Peschon JJ, Joyce S
(1997) J Exp Med 186: 331-6 - Gamma/delta T cell clones and natural killer cell clones mediate distinct patterns of non-major histocompatibility complex-restricted cytolysis.
Fisch P, Malkovsky M, Braakman E, Sturm E, Bolhuis RL, Prieve A, Sosman JA, Lam VA, Sondel PM
(1990) J Exp Med 171: 1567-79 - Insulin exits skeletal muscle capillaries by fluid-phase transport.
Williams IM, Valenzuela FA, Kahl SD, Ramkrishna D, Mezo AR, Young JD, Wells KS, Wasserman DH
(2018) J Clin Invest 128: 699-714 - Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer.
Li C, Ma H, Wang Y, Cao Z, Graves-Deal R, Powell AE, Starchenko A, Ayers GD, Washington MK, Kamath V, Desai K, Gerdes MJ, Solnica-Krezel L, Coffey RJ
(2014) J Clin Invest 124: 2172-87 - Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients.
McDonald DR, Goldman F, Gomez-Duarte OD, Issekutz AC, Kumararatne DS, Doffinger R, Geha RS
(2010) J Allergy Clin Immunol 126: 332-7, 337.e1-2 - p120-Catenin is required for mouse vascular development.
Oas RG, Xiao K, Summers S, Wittich KB, Chiasson CM, Martin WD, Grossniklaus HE, Vincent PA, Reynolds AB, Kowalczyk AP
(2010) Circ Res 106: 941-51 - A three-dimensional collagen lattice activates NF-kappaB in human fibroblasts: role in integrin alpha2 gene expression and tissue remodeling.
Xu J, Zutter MM, Santoro SA, Clark RA
(1998) J Cell Biol 140: 709-19 - PDGF induction of alpha 2 integrin gene expression is mediated by protein kinase C-zeta.
Xu J, Zutter MM, Santoro SA, Clark RA
(1996) J Cell Biol 134: 1301-11 - Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis.
Baschieri F, Confalonieri S, Bertalot G, Di Fiore PP, Dietmaier W, Leist M, Crespo P, Macara IG, Farhan H
(2014) Nat Commun 5: 4839 - Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.
Mkhikian H, Grigorian A, Li CF, Chen HL, Newton B, Zhou RW, Beeton C, Torossian S, Tatarian GG, Lee SU, Lau K, Walker E, Siminovitch KA, Chandy KG, Yu Z, Dennis JW, Demetriou M
(2011) Nat Commun 2: 334 - Vascular endothelial growth factor is upregulated by L-dopa in the parkinsonian brain: implications for the development of dyskinesia.
Ohlin KE, Francardo V, Lindgren HS, Sillivan SE, O'Sullivan SS, Luksik AS, Vassoler FM, Lees AJ, Konradi C, Cenci MA
(2011) Brain 134: 2339-57 - Cell-free pool of CD14 mediates activation of transcription factor NF-kappa B by lipopolysaccharide in human endothelial cells.
Read MA, Cordle SR, Veach RA, Carlisle CD, Hawiger J
(1993) Proc Natl Acad Sci U S A 90: 9887-91 - Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 by using cell-permeable peptide analogs.
Liu XY, Timmons S, Lin YZ, Hawiger J
(1996) Proc Natl Acad Sci U S A 93: 11819-24 - CD318 is a ligand for CD6.
Enyindah-Asonye G, Li Y, Ruth JH, Spassov DS, Hebron KE, Zijlstra A, Moasser MM, Wang B, Singer NG, Cui H, Ohara RA, Rasmussen SM, Fox DA, Lin F
(2017) Proc Natl Acad Sci U S A 114: E6912-E6921 - Regulation of alpha 2 integrin gene expression in cells with megakaryocytic features: a common theme of three necessary elements.
Zutter MM, Painter AA, Staatz WD, Tsung YL
(1995) Blood 86: 3006-14 - Increased apoptosis of peripheral blood T cells following allogeneic hematopoietic cell transplantation.
Lin MT, Tseng LH, Frangoul H, Gooley T, Pei J, Barsoukov A, Akatsuka Y, Hansen JA
(2000) Blood 95: 3832-9 - Binding of phosphorylated Sp1 protein to tandem Sp1 binding sites regulates alpha2 integrin gene core promoter activity.
Zutter MM, Ryan EE, Painter AD
(1997) Blood 90: 678-89 - Differential regulation of CXCR2 trafficking by Rab GTPases.
Fan GH, Lapierre LA, Goldenring JR, Richmond A
(2003) Blood 101: 2115-24 - Thrombin induces endocytosis of endoglin and type-II TGF-beta receptor and down-regulation of TGF-beta signaling in endothelial cells.
Tang H, Low B, Rutherford SA, Hao Q
(2005) Blood 105: 1977-85 - Downstream events in mammary gland morphogenesis mediated by reexpression of the alpha2beta1 integrin: the role of the alpha6 and beta4 integrin subunits.
Sun H, Santoro SA, Zutter MM
(1998) Cancer Res 58: 2224-33 - Repetitive weekly cycles of interleukin 2: effect of outpatient treatment with a lower dose of interleukin 2 on non-major histocompatibility complex-restricted killer activity.
Goldstein D, Sosman JA, Hank JA, Weil-Hillman G, Moore KH, Borchert A, Bechhofer R, Storer B, Kohler PC, Levitt D
(1989) Cancer Res 49: 6832-9 - ALCAM/CD166 is a TGF-β-responsive marker and functional regulator of prostate cancer metastasis to bone.
Hansen AG, Arnold SA, Jiang M, Palmer TD, Ketova T, Merkel A, Pickup M, Samaras S, Shyr Y, Moses HL, Hayward SW, Sterling JA, Zijlstra A
(2014) Cancer Res 74: 1404-15 - Elevated ALCAM shedding in colorectal cancer correlates with poor patient outcome.
Hansen AG, Freeman TJ, Arnold SA, Starchenko A, Jones-Paris CR, Gilger MA, Washington MK, Fan KH, Shyr Y, Beauchamp RD, Zijlstra A
(2013) Cancer Res 73: 2955-64 - Coexpression of CD9 augments the ability of membrane-bound heparin-binding epidermal growth factor-like growth factor (proHB-EGF) to preserve renal epithelial cell viability.
Takemura T, Hino S, Murata Y, Yanagida H, Okada M, Yoshioka K, Harris RC
(1999) Kidney Int 55: 71-81 - Notch promotes radioresistance of glioma stem cells.
Wang J, Wakeman TP, Lathia JD, Hjelmeland AB, Wang XF, White RR, Rich JN, Sullenger BA
(2010) Stem Cells 28: 17-28 - Responsiveness of human T lymphocytes to bacterial superantigens presented by cultured rheumatoid arthritis synoviocytes.
Tsai C, Diaz LA, Singer NG, Li LL, Kirsch AH, Mitra R, Nickoloff BJ, Crofford LJ, Fox DA
(1996) Arthritis Rheum 39: 125-36
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