Release of prostaglandin D2 into human airways during acute antigen challenge. Murray JJ, Tonnel AB, Brash AR, Roberts LJ, Gosset P, Workman R, Capron A, Oates JA (1986) N Engl J Med 315: 800-4 Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O'Donnell CJ, Brown NJ, Waterman MR, Capdevila JH (2005) Circulation 111: 63-9 A review of possible roles of the platelet 12-lipoxygenase. Brash AR (1985) Circulation 72: 702-7 ω-Alkynyl lipid surrogates for polyunsaturated fatty acids: free radical and enzymatic oxidations. Beavers WN, Serwa R, Shimozu Y, Tallman KA, Vaught M, Dalvie ED, Marnett LJ, Porter NA (2014) J Am Chem Soc 136: 11529-39 Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Holla VR, Adas F, Imig JD, Zhao X, Price E, Olsen N, Kovacs WJ, Magnuson MA, Keeney DS, Breyer MD, Falck JR, Waterman MR, Capdevila JH (2001) Proc Natl Acad Sci U S A 98: 5211-6 Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. Gangadhariah MH, Luther JM, Garcia V, Paueksakon P, Zhang MZ, Hayward SW, Love HD, Falck JR, Manthati VL, Imig JD, Schwartzman ML, Zent R, Capdevila JH, Pozzi A (2015) J Am Soc Nephrol 26: 597-610 15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells. Shappell SB, Gupta RA, Manning S, Whitehead R, Boeglin WE, Schneider C, Case T, Price J, Jack GS, Wheeler TM, Matusik RJ, Brash AR, Dubois RN (2001) Cancer Res 61: 497-503 The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension. Laffer CL, Gainer JV, Waterman MR, Capdevila JH, Laniado-Schwartzman M, Nasjletti A, Brown NJ, Elijovich F (2008) Hypertension 51: 767-72 Stereospecificity of hydrogen abstraction in the conversion of arachidonic acid to 15R-HETE by aspirin-treated cyclooxygenase-2. Implications for the alignment of substrate in the active site. Schneider C, Brash AR (2000) J Biol Chem 275: 4743-6 A short-chain aldehyde is a major lipoxygenase product in arachidonic acid-stimulated porcine leukocytes. Glasgow WC, Harris TM, Brash AR (1986) J Biol Chem 261: 200-4 Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol. Kozak KR, Prusakiewicz JJ, Rowlinson SW, Schneider C, Marnett LJ (2001) J Biol Chem 276: 30072-7 Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349. Schneider C, Boeglin WE, Prusakiewicz JJ, Rowlinson SW, Marnett LJ, Samel N, Brash AR (2002) J Biol Chem 277: 478-85 Allene oxide and aldehyde biosynthesis in starfish oocytes. Brash AR, Hughes MA, Hawkins DJ, Boeglin WE, Song WC, Meijer L (1991) J Biol Chem 266: 22926-31 Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading. Capdevila JH, Wei S, Yan J, Karara A, Jacobson HR, Falck JR, Guengerich FP, DuBois RN (1992) J Biol Chem 267: 21720-6 Substitution of 15-hydroxyeicosatetraenoic acid in the phosphoinositide signaling pathway. Legrand AB, Lawson JA, Meyrick BO, Blair IA, Oates JA (1991) J Biol Chem 266: 7570-7 The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3. Capdevila JH, Wei S, Helvig C, Falck JR, Belosludtsev Y, Truan G, Graham-Lorence SE, Peterson JA (1996) J Biol Chem 271: 22663-71 20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR. Savas Ü, Wei S, Hsu MH, Falck JR, Guengerich FP, Capdevila JH, Johnson EF (2016) J Biol Chem 291: 16904-19 Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition. Albertolle ME, Kim D, Nagy LD, Yun CH, Pozzi A, Savas Ü, Johnson EF, Guengerich FP (2017) J Biol Chem 292: 11230-11242 Stereospecific induction of starfish oocyte maturation by (8R)-hydroxyeicosatetraenoic acid. Meijer L, Brash AR, Bryant RW, Ng K, Maclouf J, Sprecher H (1986) J Biol Chem 261: 17040-7 Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete. Rowlinson SW, Crews BC, Goodwin DC, Schneider C, Gierse JK, Marnett LJ (2000) J Biol Chem 275: 6586-91 Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes. Nassar GM, Morrow JD, Roberts LJ, Lakkis FG, Badr KF (1994) J Biol Chem 269: 27631-4 Formation of a novel dihydroxy acid from arachidonic acid by lipoxygenase-catalyzed double oxygenation in rat mononuclear cells and human leukocytes. Maas RL, Turk J, Oates JA, Brash AR (1982) J Biol Chem 257: 7056-67 15-lipoxygenase-2 (15-LOX-2) is expressed in benign prostatic epithelium and reduced in prostate adenocarcinoma. Shappell SB, Boeglin WE, Olson SJ, Kasper S, Brash AR (1999) Am J Pathol 155: 235-45 Biosynthesis, isolation, and NMR analysis of leukotriene A epoxides: substrate chirality as a determinant of the cis or trans epoxide configuration. Jin J, Zheng Y, Boeglin WE, Brash AR (2013) J Lipid Res 54: 754-61 A novel role for activating transcription factor-2 in 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis. Zhao T, Wang D, Cheranov SY, Karpurapu M, Chava KR, Kundumani-Sridharan V, Johnson DA, Penn JS, Rao GN (2009) J Lipid Res 50: 521-33 Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments. Griesser M, Boeglin WE, Suzuki T, Schneider C (2009) J Lipid Res 50: 2455-62 COX-2-dependent and -independent biosynthesis of dihydroxy-arachidonic acids in activated human leukocytes. Tejera N, Boeglin WE, Suzuki T, Schneider C (2012) J Lipid Res 53: 87-94 Identification and absolute configuration of dihydroxy-arachidonic acids formed by oxygenation of 5S-HETE by native and aspirin-acetylated COX-2. Mulugeta S, Suzuki T, Hernandez NT, Griesser M, Boeglin WE, Schneider C (2010) J Lipid Res 51: 575-85 The hepoxilin connection in the epidermis. Brash AR, Yu Z, Boeglin WE, Schneider C (2007) FEBS J 274: 3494-3502 Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases. Capdevila JH (2007) Curr Opin Nephrol Hypertens 16: 465-70 Intermolecular peroxyl radical reactions during autoxidation of hydroxy and hydroperoxy arachidonic acids generate a novel series of epoxidized products. Schneider C, Boeglin WE, Yin H, Porter NA, Brash AR (2008) Chem Res Toxicol 21: 895-903 Mechanism of biosynthesis of 11R-and 12R-hydroxyeicosatetraenoic acids by eggs of the sea urchin Strongylocentrotus purpuratus. Hawkins DJ, Brash AR (1989) FEBS Lett 247: 9-12 15(S)-HETE production in human retinal microvascular endothelial cells by hypoxia: Novel role for MEK1 in 15(S)-HETE induced angiogenesis. Bajpai AK, Blaskova E, Pakala SB, Zhao T, Glasgow WC, Penn JS, Johnson DA, Rao GN (2007) Invest Ophthalmol Vis Sci 48: 4930-8 Detection and subcellular localization of two 15S-lipoxygenases in human cornea. Chang MS, Schneider C, Roberts RL, Shappell SB, Haselton FR, Boeglin WE, Brash AR (2005) Invest Ophthalmol Vis Sci 46: 849-56 Mechanism of hydroperoxide reduction by mangano-prostaglandin endoperoxide synthase. Landino LM, Marnett LJ (1996) Biochemistry 35: 2637-43 Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamide. Kozak KR, Prusakiewicz JJ, Rowlinson SW, Prudhomme DR, Marnett LJ (2003) Biochemistry 42: 9041-9 Detection and cellular localization of 12R-lipoxygenase in human tonsils. Schneider C, Keeney DS, Boeglin WE, Brash AR (2001) Arch Biochem Biophys 386: 268-74 Rabbit reticulocyte lipoxygenase catalyzes specific 12(S) and 15(S) oxygenation of arachidonoyl-phosphatidylcholine. Murray JJ, Brash AR (1988) Arch Biochem Biophys 265: 514-23 Investigation of the allene oxide pathway in the coral Plexaura homomalla: formation of novel ketols and isomers of prostaglandin A2 from 15-hydroxyeicosatetraenoic acid. Song WC, Brash AR (1991) Arch Biochem Biophys 290: 427-35 7-HETE, 10-HETE, and 13-HETE are major products of NADPH-dependent arachidonic acid metabolism in rat liver microsomes: analysis of their stereochemistry, and the stereochemistry of their acid-catalyzed rearrangement. Brash AR, Boeglin WE, Capdevila JH, Yeola S, Blair IA (1995) Arch Biochem Biophys 321: 485-92
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