Genetic architecture of transcript-level variation in humans. Duan S, Huang RS, Zhang W, Bleibel WK, Roe CA, Clark TA, Chen TX, Schweitzer AC, Blume JE, Cox NJ, Dolan ME (2008) Am J Hum Genet 82: 1101-13 Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer. Guengerich FP, Johnson WW, Ueng YF, Yamazaki H, Shimada T (1996) Environ Health Perspect 104 Suppl 3: 557-62 Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with forearm vasodilator responses in humans. Lee CR, Pretorius M, Schuck RN, Burch LH, Bartlett J, Williams SM, Zeldin DC, Brown NJ (2011) Hypertension 57: 116-22 Kinetics of hydrolysis and reaction of aflatoxin B1 exo-8,9-epoxide and relevance to toxicity and detoxication. Guengerich FP, Johnson WW (1999) Drug Metab Rev 31: 141-58 Activation and detoxication of aflatoxin B1. Guengerich FP, Johnson WW, Shimada T, Ueng YF, Yamazaki H, Langouët S (1998) Mutat Res 402: 121-8 Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples. Guengerich FP, Turvy CG (1991) J Pharmacol Exp Ther 256: 1189-94 Association of gain-of-function EPHX2 polymorphism Lys55Arg with acute kidney injury following cardiac surgery. Shuey MM, Billings FT, Wei S, Milne GL, Nian H, Yu C, Brown NJ (2017) PLoS One 12: e0175292 Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase. Shimada T, Gillam EM, Oda Y, Tsumura F, Sutter TR, Guengerich FP, Inoue K (1999) Chem Res Toxicol 12: 623-9 Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase. Johnson WW, Yamazaki H, Shimada T, Ueng YF, Guengerich FP (1997) Chem Res Toxicol 10: 672-6 Formation of 1,N2- and N2,3-ethenoguanine from 2-halooxiranes: isotopic labeling studies and isolation of a hemiaminal derivative of N2-(2-oxoethyl)guanine. Guengerich FP, Persmark M, Humphreys WG (1993) Chem Res Toxicol 6: 635-48 Genetic determinants of variability in warfarin response after the dose-titration phase. Iwuchukwu OF, Ramirez AH, Shi Y, Bowton EA, Kawai VK, Schildcrout JS, Roden DM, Denny JC, Stein CM (2016) Pharmacogenet Genomics 26: 510-516 Identification of a common cytochrome P450 epitope near the conserved heme-binding petide with antibodies raised against recombinant cytochrome P450 family 2 proteins. Soucek P, Martin MV, Ueng YF, Guengerich FP (1995) Biochemistry 34: 16013-21 Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis. Zeldin DC, Wei S, Falck JR, Hammock BD, Snapper JR, Capdevila JH (1995) Arch Biochem Biophys 316: 443-51 Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study. Burdon KP, Lehtinen AB, Langefeld CD, Carr JJ, Rich SS, Freedman BI, Herrington D, Bowden DW (2008) Diab Vasc Dis Res 5: 128-34 Arg287Gln variant of EPHX2 and epoxyeicosatrienoic acids are associated with insulin sensitivity in humans. Ramirez CE, Shuey MM, Milne GL, Gilbert K, Hui N, Yu C, Luther JM, Brown NJ (2014) Prostaglandins Other Lipid Mediat 113-115: 38-44 Steric analysis of epoxyalcohol and trihydroxy derivatives of 9-hydroperoxy-linoleic acid from hematin and enzymatic synthesis. Thomas CP, Boeglin WE, Garcia-Diaz Y, O'Donnell VB, Brash AR (2013) Chem Phys Lipids 167-168: 21-32
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.