Structural basis for bile acid binding and activation of the nuclear receptor FXR. Mi LZ, Devarakonda S, Harp JM, Han Q, Pellicciari R, Willson TM, Khorasanizadeh S, Rastinejad F (2003) Mol Cell 11: 1093-100 Role of Bile Acids and GLP-1 in Mediating the Metabolic Improvements of Bariatric Surgery. Albaugh VL, Banan B, Antoun J, Xiong Y, Guo Y, Ping J, Alikhan M, Clements BA, Abumrad NN, Flynn CR (2019) Gastroenterology 156: 1041-1051.e4 Elevated cholesterol and bile acid synthesis in an adult patient with homozygous familial hypercholesterolemia. Reduction by a high glucose diet. Stacpoole PW, Grundy SM, Swift LL, Greene HL, Slonim AE, Burr IM (1981) J Clin Invest 68: 1166-71 The metabolism of 3alpha, 7alpha, 12alpha-trihydorxy-5beta-cholestan-26-oic acid in two siblings with cholestasis due to intrahepatic bile duct anomalies. An apparent inborn error of cholic acid synthesis. Hanson RF, Isenberg JN, Williams GC, Hachey D, Szczepanik P, Klein PD, Sharp HL (1975) J Clin Invest 56: 577-87 Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. Peng D, Belkhiri A, Hu T, Chaturvedi R, Asim M, Wilson KT, Zaika A, El-Rifai W (2012) Gut 61: 1250-60 Cytochromes P450 in synthesis of steroid hormones, bile acids, vitamin D3 and cholesterol. Pikuleva I, Waterman M (1999) Mol Aspects Med 20: 33-42, 43-37 Bile acids and bariatric surgery. Albaugh VL, Banan B, Ajouz H, Abumrad NN, Flynn CR (2017) Mol Aspects Med 56: 75-89 Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery. Flynn CR, Albaugh VL, Cai S, Cheung-Flynn J, Williams PE, Brucker RM, Bordenstein SR, Guo Y, Wasserman DH, Abumrad NN (2015) Nat Commun 6: 7715 Intestinal bile acids directly modulate the structure and function of TcdB toxin. Tam J, Icho S, Utama E, Orrell KE, Gómez-Biagi RF, Theriot CM, Kroh HK, Rutherford SA, Lacy DB, Melnyk RA (2020) Proc Natl Acad Sci U S A 117: 6792-6800 Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids. Nagathihalli NS, Beesetty Y, Lee W, Washington MK, Chen X, Lockhart AC, Merchant NB (2014) Cancer Res 74: 2062-72 Stable isotope ratiometer-multiple ion detector unit for quantitative and qualitative stable isotope studies by gas chromatography-mass spectrometry. Klein PD, Haumann JR, Hachey DL (1975) Clin Chem 21: 1253-7 APE1-mediated DNA damage repair provides survival advantage for esophageal adenocarcinoma cells in response to acidic bile salts. Hong J, Chen Z, Peng D, Zaika A, Revetta F, Washington MK, Belkhiri A, El-Rifai W (2016) Oncotarget 7: 16688-702 Early Increases in Bile Acids Post Roux-en-Y Gastric Bypass Are Driven by Insulin-Sensitizing, Secondary Bile Acids. Albaugh VL, Flynn CR, Cai S, Xiao Y, Tamboli RA, Abumrad NN (2015) J Clin Endocrinol Metab 100: E1225-33 CD36 Modulates Fasting and Preabsorptive Hormone and Bile Acid Levels. Shibao CA, Celedonio JE, Tamboli R, Sidani R, Love-Gregory L, Pietka T, Xiong Y, Wei Y, Abumrad NN, Abumrad NA, Flynn CR (2018) J Clin Endocrinol Metab 103: 1856-1866 p73 protein regulates DNA damage repair. Zaika E, Wei J, Yin D, Andl C, Moll U, El-Rifai W, Zaika AI (2011) FASEB J 25: 4406-14 Utilizing Untargeted Ion Mobility-Mass Spectrometry To Profile Changes in the Gut Metabolome Following Biliary Diversion Surgery. Poland JC, Schrimpe-Rutledge AC, Sherrod SD, Flynn CR, McLean JA (2019) Anal Chem 91: 14417-14423 Prevention of DNA damage in Barrett's esophageal cells exposed to acidic bile salts. Bhardwaj V, Horvat A, Korolkova O, Washington MK, El-Rifai W, Dikalov SI, Zaika AI (2016) Carcinogenesis 37: 1161-1169 Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Qiao L, Han SI, Fang Y, Park JS, Gupta S, Gilfor D, Amorino G, Valerie K, Sealy L, Engelhardt JF, Grant S, Hylemon PB, Dent P (2003) Mol Cell Biol 23: 3052-66 A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression. Marzolini C, Tirona RG, Gervasini G, Poonkuzhali B, Assem M, Lee W, Leake BF, Schuetz JD, Schuetz EG, Kim RB (2007) Mol Endocrinol 21: 1769-80 Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways. Pikuleva IA, Babiker A, Waterman MR, Björkhem I (1998) J Biol Chem 273: 18153-60 Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition. Ho RH, Leake BF, Roberts RL, Lee W, Kim RB (2004) J Biol Chem 279: 7213-22 Systemic bile acids induce insulin resistance in a TGR5-independent manner. Syring KE, Cyphert TJ, Beck TC, Flynn CR, Mignemi NA, McGuinness OP (2019) Am J Physiol Endocrinol Metab 316: E782-E793 Evaluation of Poly S-179 as a stationary phase for the gas-liquid chromatography-mass-spectrometry of bile acid methyl ester acetates. Szczepanik PA, Hachey DL, Klein PD (1978) J Lipid Res 19: 280-3 An improved procedure for the synthesis of glycine and taurine conjugates of bile acids. Tserng KY, Hachey DL, Klein PD (1977) J Lipid Res 18: 404-7 Characterization of bile acid methyl ester acetate derivatives using gas-liquid chromatography, electron impact, and chemical ionization mass spectrometry. Szczepanik PA, Hachey DL, Klein PD (1976) J Lipid Res 17: 314-34 Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity. Kim RB, Leake B, Cvetkovic M, Roden MM, Nadeau J, Walubo A, Wilkinson GR (1999) J Pharmacol Exp Ther 291: 1204-9 Proinflammatory cytokines and bile acids upregulate ΔNp73 protein, an inhibitor of p53 and p73 tumor suppressors. Zaika E, Bhardwaj V, Wei J, Washington MK, Souza R, El-Rifai W, Zaika A (2013) PLoS One 8: e64306 Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability. Ho RH, Leake BF, Kilkenny DM, Meyer Zu Schwabedissen HE, Glaeser H, Kroetz DL, Kim RB (2010) Pharmacogenet Genomics 20: 45-57 Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Merchant NB, Rogers CM, Trivedi B, Morrow J, Coffey RJ (2005) Surgery 138: 415-21 Functional characterization of genetic variants in the apical sodium-dependent bile acid transporter (ASBT; SLC10A2). Ho RH, Leake BF, Urquhart BL, Gregor JC, Dawson PA, Kim RB (2011) J Gastroenterol Hepatol 26: 1740-8 Activation of NADPH oxidases leads to DNA damage in esophageal cells. Bhardwaj V, Gokulan RC, Horvat A, Yermalitskaya L, Korolkova O, Washington KM, El-Rifai W, Dikalov SI, Zaika AI (2017) Sci Rep 7: 9956 Separation of bile acids as their phenacyl esters by high-pressure liquid chromatography. Stellaard F, Hachey DL, Klein PD (1978) Anal Biochem 87: 359-66 Active bile salt transport in the ileum: characteristics and ontogeny. Acra SA, Ghishan FK (1990) J Pediatr Gastroenterol Nutr 10: 421-5
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.