The E2F transcription factor is a cellular target for the RB protein. Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR (1991) Cell 65: 1053-61 Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Mudryj M, Devoto SH, Hiebert SW, Hunter T, Pines J, Nevins JR (1991) Cell 65: 1243-53 E2F-1 induces the stabilization of p53 but blocks p53-mediated transactivation. Nip J, Strom DK, Eischen CM, Cleveland JL, Zambetti GP, Hiebert SW (2001) Oncogene 20: 910-20 Dual control of myc expression through a single DNA binding site targeted by ets family proteins and E2F-1. Roussel MF, Davis JN, Cleveland JL, Ghysdael J, Hiebert SW (1994) Oncogene 9: 405-15 An E2F dominant negative mutant blocks E1A induced cell cycle progression. Dobrowolski SF, Stacey DW, Harter ML, Stine JT, Hiebert SW (1994) Oncogene 9: 2605-12 E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis. Hiebert SW, Packham G, Strom DK, Haffner R, Oren M, Zambetti G, Cleveland JL (1995) Mol Cell Biol 15: 6864-74 Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression. Hiebert SW (1993) Mol Cell Biol 13: 3384-91 E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis. Nip J, Strom DK, Fee BE, Zambetti G, Cleveland JL, Hiebert SW (1997) Mol Cell Biol 17: 1049-56 Oncogenes induce and activate endogenous p73 protein. Zaika A, Irwin M, Sansome C, Moll UM (2001) J Biol Chem 276: 11310-6 c-myc-enhanced S phase entry in keratinocytes is associated with positive and negative effects on cyclin-dependent kinases. Alexandrow MG, Moses HL (1998) J Cell Biochem 70: 528-42 Indirect and direct disruption of transcriptional regulation in cancer: E2F and AML-1. Meyers S, Hiebert SW (1995) Crit Rev Eukaryot Gene Expr 5: 365-83 Topoisomerase IIalpha mediates E2F-1-induced chemosensitivity and is a target for p53-mediated transcriptional repression. Nip J, Hiebert SW (2000) Cell Biochem Biophys 33: 199-207
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