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•  Charles Flynn

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Publications

• A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.
  Rameh LE, Tolias KF, Duckworth BC, Cantley LC
  (1997) Nature 390: 192-6
• Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins.
  Rameh LE, Chen CS, Cantley LC
  (1995) Cell 83: 821-30
• Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.
  Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC
  (2013) Cell 155: 844-57
• Prenatal exposure to drugs: effects on brain development and implications for policy and education.
  Thompson BL, Levitt P, Stanwood GD
  (2009) Nat Rev Neurosci 10: 303-12
• A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.
  Odom AR, Stahlberg A, Wente SR, York JD
  (2000) Science 287: 2026-9
• A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.
  York JD, Odom AR, Murphy R, Ives EB, Wente SR
  (1999) Science 285: 96-100
• Regulation of chromatin remodeling by inositol polyphosphates.
  Steger DJ, Haswell ES, Miller AL, Wente SR, O'Shea EK
  (2003) Science 299: 114-6
• The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.
  Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H
  (2009) Nat Immunol 10: 769-77
• mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.
  Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, Sabatini DM
  (2009) Cancer Cell 15: 148-59
• Interstrand DNA cross-links induced by alpha,beta-unsaturated aldehydes derived from lipid peroxidation and environmental sources.
  Stone MP, Cho YJ, Huang H, Kim HY, Kozekov ID, Kozekova A, Wang H, Minko IG, Lloyd RS, Harris TM, Rizzo CJ
  (2008) Acc Chem Res 41: 793-804
• Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology Group.
  Blanco JG, Sun CL, Landier W, Chen L, Esparza-Duran D, Leisenring W, Mays A, Friedman DL, Ginsberg JP, Hudson MM, Neglia JP, Oeffinger KC, Ritchey AK, Villaluna D, Relling MV, Bhatia S
  (2012) J Clin Oncol 30: 1415-21
• MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.
  Dovey CM, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, Brown NW, Cao JY, Grace CR, Gough PJ, Bertin J, Dixon SJ, Fiedler D, Mocarski ES, Kaiser WJ, Moldoveanu T, York JD, Carette JE
  (2018) Mol Cell 70: 936-948.e7
• Parental alcohol consumption, cigarette smoking, and risk of infant leukemia: a Childrens Cancer Group study.
  Shu XO, Ross JA, Pendergrass TW, Reaman GH, Lampkin B, Robison LL
  (1996) J Natl Cancer Inst 88: 24-31
• Nonalcoholic Fatty Liver Disease and Incident Cardiac Events: The Multi-Ethnic Study of Atherosclerosis.
  Zeb I, Li D, Budoff MJ, Katz R, Lloyd-Jones D, Agatston A, Blumenthal RS, Blaha MJ, Blankstein R, Carr J, Nasir K
  (2016) J Am Coll Cardiol 67: 1965-6
• Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons.
  Griffin MR, Piper JM, Daugherty JR, Snowden M, Ray WA
  (1991) Ann Intern Med 114: 257-63
• Inositol polyphosphates regulate zebrafish left-right asymmetry.
  Sarmah B, Latimer AJ, Appel B, Wente SR
  (2005) Dev Cell 9: 133-45
• Alcohol Use and Cardiovascular Disease Risk in Patients With Nonalcoholic Fatty Liver Disease.
  VanWagner LB, Ning H, Allen NB, Ajmera V, Lewis CE, Carr JJ, Lloyd-Jones DM, Terrault NA, Siddique J
  (2017) Gastroenterology 153: 1260-1272.e3
• Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.
  Li JZ, Huang Y, Karaman R, Ivanova PT, Brown HA, Roddy T, Castro-Perez J, Cohen JC, Hobbs HH
  (2012) J Clin Invest 122: 4130-44
• Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
  Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Livingston K, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC
  (2015) J Clin Invest 125: 4447-62
• Selective disruption of genes expressed in totipotent embryonal stem cells.
  von Melchner H, DeGregori JV, Rayburn H, Reddy S, Friedel C, Ruley HE
  (1992) Genes Dev 6: 919-27
• Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent.
  Palmer ND, Musani SK, Yerges-Armstrong LM, Feitosa MF, Bielak LF, Hernaez R, Kahali B, Carr JJ, Harris TB, Jhun MA, Kardia SL, Langefeld CD, Mosley TH, Norris JM, Smith AV, Taylor HA, Wagenknecht LE, Liu J, Borecki IB, Peyser PA, Speliotes EK
  (2013) Hepatology 58: 966-75
• Association of nonalcoholic fatty liver disease with subclinical myocardial remodeling and dysfunction: A population-based study.
  VanWagner LB, Wilcox JE, Colangelo LA, Lloyd-Jones DM, Carr JJ, Lima JA, Lewis CE, Rinella ME, Shah SJ
  (2015) Hepatology 62: 773-83
• A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast.
  Mitra P, Zhang Y, Rameh LE, Ivshina MP, McCollum D, Nunnari JJ, Hendricks GM, Kerr ML, Field SJ, Cantley LC, Ross AH
  (2004) J Cell Biol 166: 205-11
• Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides.
  Egli M, Pallan PS, Allerson CR, Prakash TP, Berdeja A, Yu J, Lee S, Watt A, Gaus H, Bhat B, Swayze EE, Seth PP
  (2011) J Am Chem Soc 133: 16642-9
• Isotope-Labeling Studies Support the Electrophilic Compound I Iron Active Species, FeO(3+), for the Carbon-Carbon Bond Cleavage Reaction of the Cholesterol Side-Chain Cleavage Enzyme, Cytochrome P450 11A1.
  Yoshimoto FK, Jung IJ, Goyal S, Gonzalez E, Guengerich FP
  (2016) J Am Chem Soc 138: 12124-41
• Alcohol intake increases high-grade prostate cancer risk among men taking dutasteride in the REDUCE trial.
  Fowke JH, Howard L, Andriole GL, Freedland SJ
  (2014) Eur Urol 66: 1133-8
• Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease.
  Leamy AK, Egnatchik RA, Young JD
  (2013) Prog Lipid Res 52: 165-74
• S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease.
  Martínez-Uña M, Varela-Rey M, Mestre D, Fernández-Ares L, Fresnedo O, Fernandez-Ramos D, Gutiérrez-de Juan V, Martin-Guerrero I, García-Orad A, Luka Z, Wagner C, Lu SC, García-Monzón C, Finnell RH, Aurrekoetxea I, Buqué X, Martínez-Chantar ML, Mato JM, Aspichueta P
  (2015) J Hepatol 62: 673-81
• Longer lactation duration is associated with decreased prevalence of non-alcoholic fatty liver disease in women.
  Ajmera VH, Terrault NA, VanWagner LB, Sarkar M, Lewis CE, Carr JJ, Gunderson EP
  (2019) J Hepatol 70: 126-132
• Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis.
  Legate KR, Takahashi S, Bonakdar N, Fabry B, Boettiger D, Zent R, Fässler R
  (2011) EMBO J 30: 4539-53
• Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress.
  McElligott ZA, Klug JR, Nobis WP, Patel S, Grueter BA, Kash TL, Winder DG
  (2010) Proc Natl Acad Sci U S A 107: 2271-6
• A role for the inositol kinase Ipk1 in ciliary beating and length maintenance.
  Sarmah B, Winfrey VP, Olson GE, Appel B, Wente SR
  (2007) Proc Natl Acad Sci U S A 104: 19843-8
• Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes.
  Carneiro AM, Airey DC, Thompson B, Zhu CB, Lu L, Chesler EJ, Erikson KM, Blakely RD
  (2009) Proc Natl Acad Sci U S A 106: 2047-52
• Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila.
  Seeds AM, Tsui MM, Sunu C, Spana EP, York JD
  (2015) Proc Natl Acad Sci U S A 112: 15660-5
• The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation.
  Carricaburu V, Lamia KA, Lo E, Favereaux L, Payrastre B, Cantley LC, Rameh LE
  (2003) Proc Natl Acad Sci U S A 100: 9867-72
• Behavioral and demographic risk factors for transmission of human immunodeficiency virus type 1 in heterosexual couples: report from the Heterosexual HIV Transmission Study.
  Skurnick JH, Kennedy CA, Perez G, Abrams J, Vermund SH, Denny T, Wright T, Quinones MA, Louria DB
  (1998) Clin Infect Dis 26: 855-64
• Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia.
  Arion D, Unger T, Lewis DA, Levitt P, Mirnics K
  (2007) Biol Psychiatry 62: 711-21
• Endocannabinoid control of the insular-bed nucleus of the stria terminalis circuit regulates negative affective behavior associated with alcohol abstinence.
  Centanni SW, Morris BD, Luchsinger JR, Bedse G, Fetterly TL, Patel S, Winder DG
  (2019) Neuropsychopharmacology 44: 526-537
• Ketamine administration during a critical period after forced ethanol abstinence inhibits the development of time-dependent affective disturbances.
  Vranjkovic O, Winkler G, Winder DG
  (2018) Neuropsychopharmacology 43: 1915-1923