Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine [seecomments]. Fromm MF, Kim RB, Stein CM, Wilkinson GR, Roden DM (1999) Circulation 99: 552-7 Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes. Shimada T, Guengerich FP (1991) Cancer Res 51: 5284-91 Mexiletine and tocainide: a comparison of antiarrhythmic efficacy, adverse effects, and predictive value of lidocaine testing. Murray KT, Barbey JT, Kopelman HA, Siddoway LA, Echt DS, Woosley RL, Roden DM (1989) Clin Pharmacol Ther 45: 553-61 Probing the mechanisms underlying modulation of quinidine sensitivity to cardiac I(Ks) block by protein kinase A-mediated I(Ks) phosphorylation. Yang T, Kanki H, Zhang W, Roden DM (2009) Br J Pharmacol 157: 952-61 Genetic susceptibility to acquired long QT syndrome: pharmacologic challenge in first-degree relatives. Kannankeril PJ, Roden DM, Norris KJ, Whalen SP, George AL, Murray KT (2005) Heart Rhythm 2: 134-40 Inhibition of human cytochrome P450 3A4 by cholesterol. Shinkyo R, Guengerich FP (2011) J Biol Chem 286: 18426-33 Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease. Bajpai P, Sangar MC, Singh S, Tang W, Bansal S, Chowdhury G, Cheng Q, Fang JK, Martin MV, Guengerich FP, Avadhani NG (2013) J Biol Chem 288: 4436-51 Evidence for a role of a perferryl-oxygen complex, FeO3+, in the N-oxygenation of amines by cytochrome P450 enzymes. Guengerich FP, Vaz AD, Raner GN, Pernecky SJ, Coon MJ (1997) Mol Pharmacol 51: 147-51 An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1. Yang T, Smith JA, Leake BF, Sanders CR, Meiler J, Roden DM (2013) Mol Pharmacol 83: 481-9 Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan. Nguyen L, Robson MJ, Healy JR, Scandinaro AL, Matsumoto RR (2014) PLoS One 9: e89985 Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis. Guengerich FP, Hanna IH, Martin MV, Gillam EM (2003) Biochemistry 42: 1245-53 Coumarin substrates for cytochrome P450 2D6 fluorescence assays. Nakamura K, Hanna IH, Cai H, Nishimura Y, Williams KM, Guengerich FP (2001) Anal Biochem 292: 280-6 The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel. McBride BF, Yang T, Liu K, Urban TJ, Giacomini KM, Kim RB, Roden DM (2009) J Cardiovasc Pharmacol 54: 63-71
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