A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A. Westphal RS, Anderson KA, Means AR, Wadzinski BE (1998) Science 280: 1258-61 Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Cole RL, Konradi C, Douglass J, Hyman SE (1995) Neuron 14: 813-23 6-Hydroxydopamine lesions of rat substantia nigra up-regulate dopamine-induced phosphorylation of the cAMP-response element-binding protein in striatal neurons. Cole DG, Kobierski LA, Konradi C, Hyman SE (1994) Proc Natl Acad Sci U S A 91: 9631-5 The cAMP-response-element-binding protein interacts, but Fos protein does not interact, with the proenkephalin enhancer in rat striatum. Konradi C, Kobierski LA, Nguyen TV, Heckers S, Hyman SE (1993) Proc Natl Acad Sci U S A 90: 7005-9 t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanism. Belkhiri A, Dar AA, Zaika A, Kelley M, El-Rifai W (2008) Cancer Res 68: 395-403 Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation. Li Y, Yokota T, Gama V, Yoshida T, Gomez JA, Ishikawa K, Sasaguri H, Cohen HY, Sinclair DA, Mizusawa H, Matsuyama S (2007) Cell Death Differ 14: 2058-67 Oxidative stress and NF-kappaB activation: correlation in patients following allogeneic bone marrow transplantation. Blackwell TS, Christman JW, Hagan T, Price P, Edens T, Morris PE, Wolff SN, Goodman SA, Christman BW (2000) Antioxid Redox Signal 2: 93-102 Gastrin-releasing peptide mediates light-like resetting of the suprachiasmatic nucleus circadian pacemaker through cAMP response element-binding protein and Per1 activation. Gamble KL, Allen GC, Zhou T, McMahon DG (2007) J Neurosci 27: 12078-87 Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens. Pliakas AM, Carlson RR, Neve RL, Konradi C, Nestler EJ, Carlezon WA (2001) J Neurosci 21: 7397-403 L-Type Ca(2+) channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal neurons. Rajadhyaksha A, Barczak A, Macías W, Leveque JC, Lewis SE, Konradi C (1999) J Neurosci 19: 6348-59 cAMP response element-binding protein is required for dopamine-dependent gene expression in the intact but not the dopamine-denervated striatum. Andersson M, Konradi C, Cenci MA (2001) J Neurosci 21: 9930-43 Amphetamine regulates gene expression in rat striatum via transcription factor CREB. Konradi C, Cole RL, Heckers S, Hyman SE (1994) J Neurosci 14: 5623-34 Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens. Dinieri JA, Nemeth CL, Parsegian A, Carle T, Gurevich VV, Gurevich E, Neve RL, Nestler EJ, Carlezon WA (2009) J Neurosci 29: 1855-9 p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration. Bakin AV, Rinehart C, Tomlinson AK, Arteaga CL (2002) J Cell Sci 115: 3193-206 Biochemical diversity of peptide-hormone-dependent regulation of steroidogenic P450s. Kagawa N, Bischof LJ, Cheng PY, Anwar A, Waterman MR (1999) Drug Metab Rev 31: 333-42 Defective Th function induced by a dominant-negative cAMP response element binding protein mutation is reversed by Bcl-2. Zhang F, Rincon M, Flavell RA, Aune TM (2000) J Immunol 165: 1762-70 Regulation of the activity of IFN-gamma promoter elements during Th cell differentiation. Zhang F, Wang DZ, Boothby M, Penix L, Flavell RA, Aune TM (1998) J Immunol 161: 6105-12 Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Qiao L, Han SI, Fang Y, Park JS, Gupta S, Gilfor D, Amorino G, Valerie K, Sealy L, Engelhardt JF, Grant S, Hylemon PB, Dent P (2003) Mol Cell Biol 23: 3052-66 Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation. Wadzinski BE, Wheat WH, Jaspers S, Peruski LF, Lickteig RL, Johnson GL, Klemm DJ (1993) Mol Cell Biol 13: 2822-34 Glucagon-Like Peptide-1 Regulates Cholecystokinin Production in β-Cells to Protect From Apoptosis. Linnemann AK, Neuman JC, Battiola TJ, Wisinski JA, Kimple ME, Davis DB (2015) Mol Endocrinol 29: 978-87 Molecular mechanisms of stress-induced proenkephalin gene regulation: CREB interacts with the proenkephalin gene in the mouse hypothalamus and is phosphorylated in response to hyperosmolar stress. Borsook D, Konradi C, Falkowski O, Comb M, Hyman SE (1994) Mol Endocrinol 8: 240-8 PTH induction of transcriptional activity of the cAMP response element-binding protein requires the serine 129 site and glycogen synthase kinase-3 activity, but not casein kinase II sites. Tyson DR, Swarthout JT, Jefcoat SC, Partridge NC (2002) Endocrinology 143: 674-82 OASIS/CREB3L1 induces expression of genes involved in extracellular matrix production but not classical endoplasmic reticulum stress response genes in pancreatic beta-cells. Vellanki RN, Zhang L, Guney MA, Rocheleau JV, Gannon M, Volchuk A (2010) Endocrinology 151: 4146-57 Increased osteoblastic c-fos expression by parathyroid hormone requires protein kinase A phosphorylation of the cyclic adenosine 3',5'-monophosphate response element-binding protein at serine 133. Tyson DR, Swarthout JT, Partridge NC (1999) Endocrinology 140: 1255-61 Neuregulin-1β induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors. Hao J, Galindo CL, Tran TL, Sawyer DB (2014) Biochem J 458: 335-41 Deregulated hepatic metabolism exacerbates impaired testosterone production in Mrp4-deficient mice. Morgan JA, Cheepala SB, Wang Y, Neale G, Adachi M, Nachagari D, Leggas M, Zhao W, Boyd K, Venkataramanan R, Schuetz JD (2012) J Biol Chem 287: 14456-66 Insulin inhibits hepatocellular glucose production by utilizing liver-enriched transcriptional inhibitory protein to disrupt the association of CREB-binding protein and RNA polymerase II with the phosphoenolpyruvate carboxykinase gene promoter. Duong DT, Waltner-Law ME, Sears R, Sealy L, Granner DK (2002) J Biol Chem 277: 32234-42 Members of the meis1 and pbx homeodomain protein families cooperatively bind a cAMP-responsive sequence (CRS1) from bovine CYP17. Bischof LJ, Kagawa N, Moskow JJ, Takahashi Y, Iwamatsu A, Buchberg AM, Waterman MR (1998) J Biol Chem 273: 7941-8 Characterization of the promoter/regulatory region of the bovine CYP11A (P-450scc) gene. Basal and cAMP-dependent expression. Ahlgren R, Simpson ER, Waterman MR, Lund J (1990) J Biol Chem 265: 3313-9 Transcriptional regulation of the bovine CYP17 (P-450(17)alpha) gene. Identification of two cAMP regulatory regions lacking the consensus cAMP-responsive element (CRE). Lund J, Ahlgren R, Wu DH, Kagimoto M, Simpson ER, Waterman MR (1990) J Biol Chem 265: 3304-12 Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex. Anderson KA, Noeldner PK, Reece K, Wadzinski BE, Means AR (2004) J Biol Chem 279: 31708-16 Depletion of cAMP-response element-binding protein/ATF1 inhibits adipogenic conversion of 3T3-L1 cells ectopically expressing CCAAT/enhancer-binding protein (C/EBP) alpha, C/EBP beta, or PPAR gamma 2. Fox KE, Fankell DM, Erickson PF, Majka SM, Crossno JT, Klemm DJ (2006) J Biol Chem 281: 40341-53 p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis. Cao W, Collins QF, Becker TC, Robidoux J, Lupo EG, Xiong Y, Daniel KW, Floering L, Collins S (2005) J Biol Chem 280: 42731-7 Insights into the transcriptional regulation of steroidogenic enzymes and StAR. Sewer MB, Waterman MR (2001) Rev Endocr Metab Disord 2: 269-74 The A2A receptor mediates an endogenous regulatory pathway of cytokine expression in THP-1 cells. Bshesh K, Zhao B, Spight D, Biaggioni I, Feokistov I, Denenberg A, Wong HR, Shanley TP (2002) J Leukoc Biol 72: 1027-36 Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue. Chartoff EH, Papadopoulou M, MacDonald ML, Parsegian A, Potter D, Konradi C, Carlezon WA (2009) Mol Pharmacol 75: 704-12 Effects of naloxone-precipitated morphine withdrawal on glutamate-mediated signaling in striatal neurons in vitro. Chartoff EH, Papadopoulou M, Konradi C, Carlezon WA (2003) Ann N Y Acad Sci 1003: 368-71 Comparison of cAMP-responsive DNA sequences and their binding proteins associated with expression of the bovine CYP17 and CYP11A and human CYP21B genes. Waterman MR, Kagawa N, Zanger UM, Momoi K, Lund J, Simpson ER (1992) J Steroid Biochem Mol Biol 43: 931-5 Analysis of the proenkephalin second messenger-inducible enhancer in rat striatal cultures. Konradi C, Cole RL, Green D, Senatus P, Leveque JC, Pollack AE, Grossbard SJ, Hyman SE (1995) J Neurochem 65: 1007-15 Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1. Dudman JT, Eaton ME, Rajadhyaksha A, Macías W, Taher M, Barczak A, Kameyama K, Huganir R, Konradi C (2003) J Neurochem 87: 922-34
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