The burden of respiratory syncytial virus infection in young children. Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM, Staat MA, Auinger P, Griffin MR, Poehling KA, Erdman D, Grijalva CG, Zhu Y, Szilagyi P (2009) N Engl J Med 360: 588-98 A RhoA-derived peptide inhibits syncytium formation induced by respiratory syncytial virus and parainfluenza virus type 3. Pastey MK, Gower TL, Spearman PW, Crowe JE, Graham BS (2000) Nat Med 6: 35-40 Progression of respiratory syncytial virus infection monitored by fluorescent quantum dot probes. Bentzen EL, House F, Utley TJ, Crowe JE, Wright DW (2005) Nano Lett 5: 591-5 TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization. Caballero MT, Serra ME, Acosta PL, Marzec J, Gibbons L, Salim M, Rodriguez A, Reynaldi A, Garcia A, Bado D, Buchholz UJ, Hijano DR, Coviello S, Newcomb D, Bellabarba M, Ferolla FM, Libster R, Berenstein A, Siniawaski S, Blumetti V, Echavarria M, Pinto L, Lawrence A, Ossorio MF, Grosman A, Mateu CG, Bayle C, Dericco A, Pellegrini M, Igarza I, Repetto HA, Grimaldi LA, Gudapati P, Polack NR, Althabe F, Shi M, Ferrero F, Bergel E, Stein RT, Peebles RS, Boothby M, Kleeberger SR, Polack FP (2015) J Clin Invest 125: 571-82 Viral acute lower respiratory infections impair CD8+ T cells through PD-1. Erickson JJ, Gilchuk P, Hastings AK, Tollefson SJ, Johnson M, Downing MB, Boyd KL, Johnson JE, Kim AS, Joyce S, Williams JV (2012) J Clin Invest 122: 2967-82 Repurposing staples for viruses: applying peptide design to RSV prophylaxis. Katen SP, Dermody TS (2014) J Clin Invest 124: 1889-91 Reply: To PMID 22336082. Carroll KN, Hartert TV (2013) J Allergy Clin Immunol 131: 616-7 Risk of childhood asthma following infant bronchiolitis during the respiratory syncytial virus season. James KM, Gebretsadik T, Escobar GJ, Wu P, Carroll KN, Li SX, Walsh EM, Mitchel EF, Sloan C, Hartert TV (2013) J Allergy Clin Immunol 132: 227-9 Influence of maternal asthma on the cause and severity of infant acute respiratory tract infections. Carroll KN, Gebretsadik T, Minton P, Woodward K, Liu Z, Miller EK, Williams JV, Dupont WD, Hartert TV (2012) J Allergy Clin Immunol 129: 1236-42 Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma. Patel DA, You Y, Huang G, Byers DE, Kim HJ, Agapov E, Moore ML, Peebles RS, Castro M, Sumino K, Shifren A, Brody SL, Holtzman MJ (2014) J Allergy Clin Immunol 134: 1402-1412.e7 Season of infant bronchiolitis and estimates of subsequent risk and burden of early childhood asthma. Carroll KN, Wu P, Gebretsadik T, Griffin MR, Dupont WD, Mitchel EF, Hartert TV (2009) J Allergy Clin Immunol 123: 964-6 Response to infections in patients with asthma and atopic disease: an epiphenomenon or reflection of host susceptibility? James KM, Peebles RS, Hartert TV (2012) J Allergy Clin Immunol 130: 343-51 Macronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children. Ferolla FM, Hijano DR, Acosta PL, Rodríguez A, Dueñas K, Sancilio A, Barboza E, Caría A, Gago GF, Almeida RE, Castro L, Pozzolo C, Martínez MV, Grimaldi LA, Rebec B, Calvo M, Henrichsen J, Nocito C, González M, Barbero G, Losada JV, Caballero MT, Zurankovas V, Raggio M, Schavlovsky G, Kobylarz A, Wimmenauer V, Bugna J, Williams JV, Sastre G, Flamenco E, Pérez AR, Ferrero F, Libster R, Grijalva CG, Polack FP (2013) Am J Respir Crit Care Med 187: 983-90 A role for genes and environment in the causal relationship between infant RSV infection and childhood asthma. Wu P, Dupont WD, Griffin MR, Hartert TV (2010) Am J Respir Crit Care Med 181: 194-5; author reply 195 Evidence of a causal role of winter virus infection during infancy in early childhood asthma. Wu P, Dupont WD, Griffin MR, Carroll KN, Mitchel EF, Gebretsadik T, Hartert TV (2008) Am J Respir Crit Care Med 178: 1123-9 Toward primary prevention of asthma. Reviewing the evidence for early-life respiratory viral infections as modifiable risk factors to prevent childhood asthma. Feldman AS, He Y, Moore ML, Hershenson MB, Hartert TV (2015) Am J Respir Crit Care Med 191: 34-44 Recombinant human respiratory syncytial virus (RSV) monoclonal antibody Fab is effective therapeutically when introduced directly into the lungs of RSV-infected mice. Crowe JE, Murphy BR, Chanock RM, Williamson RA, Barbas CF, Burton DR (1994) Proc Natl Acad Sci U S A 91: 1386-90 Influence of maternal antibodies on neonatal immunization against respiratory viruses. Crowe JE (2001) Clin Infect Dis 33: 1720-7 Suppression of airway hyperresponsiveness induced by ovalbumin sensitisation and RSV infection with Y-27632, a Rho kinase inhibitor. Hashimoto K, Peebles RS, Sheller JR, Jarzecka K, Furlong J, Mitchell DB, Hartert TV, Graham BS (2002) Thorax 57: 524-7 Live subgroup B respiratory syncytial virus vaccines that are attenuated, genetically stable, and immunogenic in rodents and nonhuman primates. Crowe JE, Bui PT, Firestone CY, Connors M, Elkins WR, Chanock RM, Murphy BR (1996) J Infect Dis 173: 829-39 Challenges and opportunities in developing respiratory syncytial virus therapeutics. Simões EA, DeVincenzo JP, Boeckh M, Bont L, Crowe JE, Griffiths P, Hayden FG, Hodinka RL, Smyth RL, Spencer K, Thirstrup S, Walsh EE, Whitley RJ (2015) J Infect Dis 211 Suppl 1: S1-S20 Isolation of a second recombinant human respiratory syncytial virus monoclonal antibody fragment (Fab RSVF2-5) that exhibits therapeutic efficacy in vivo. Crowe JE, Gilmour PS, Murphy BR, Chanock RM, Duan L, Pomerantz RJ, Pilkington GR (1998) J Infect Dis 177: 1073-6 Evaluation of two live, cold-passaged, temperature-sensitive respiratory syncytial virus vaccines in chimpanzees and in human adults, infants, and children. Karron RA, Wright PF, Crowe JE, Clements-Mann ML, Thompson J, Makhene M, Casey R, Murphy BR (1997) J Infect Dis 176: 1428-36 Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults. Widmer K, Zhu Y, Williams JV, Griffin MR, Edwards KM, Talbot HK (2012) J Infect Dis 206: 56-62 Passive IgA monoclonal antibody is no more effective than IgG at protecting mice from mucosal challenge with respiratory syncytial virus. Fisher RG, Crowe JE, Johnson TR, Tang YW, Graham BS (1999) J Infect Dis 180: 1324-7 Differences in the Nasopharyngeal Microbiome During Acute Respiratory Tract Infection With Human Rhinovirus and Respiratory Syncytial Virus in Infancy. Rosas-Salazar C, Shilts MH, Tovchigrechko A, Schobel S, Chappell JD, Larkin EK, Shankar J, Yooseph S, Nelson KE, Halpin RA, Moore ML, Anderson LJ, Peebles RS, Das SR, Hartert TV (2016) J Infect Dis 214: 1924-1928 A critical phenylalanine residue in the respiratory syncytial virus fusion protein cytoplasmic tail mediates assembly of internal viral proteins into viral filaments and particles. Shaikh FY, Cox RG, Lifland AW, Hotard AL, Williams JV, Moore ML, Santangelo PJ, Crowe JE (2012) MBio 3: Passively acquired antibodies suppress humoral but not cell-mediated immunity in mice immunized with live attenuated respiratory syncytial virus vaccines. Crowe JE, Firestone CY, Murphy BR (2001) J Immunol 167: 3910-8 STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. Moore ML, Newcomb DC, Parekh VV, Van Kaer L, Collins RD, Zhou W, Goleniewska K, Chi MH, Mitchell D, Boyce JA, Durbin JE, Sturkie C, Peebles RS (2009) J Immunol 183: 2016-26 Prophylactic and therapeutic testing of Nicotiana-derived RSV-neutralizing human monoclonal antibodies in the cotton rat model. Zeitlin L, Bohorov O, Bohorova N, Hiatt A, Kim DH, Pauly MH, Velasco J, Whaley KJ, Barnard DL, Bates JT, Crowe JE, Piedra PA, Gilbert BE (2013) MAbs 5: 263-9 Respiratory syncytial virus-associated hospitalizations among children less than 24 months of age. Hall CB, Weinberg GA, Blumkin AK, Edwards KM, Staat MA, Schultz AF, Poehling KA, Szilagyi PG, Griffin MR, Williams JV, Zhu Y, Grijalva CG, Prill MM, Iwane MK (2013) Pediatrics 132: e341-8 STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge. Dulek DE, Newcomb DC, Toki S, Goliniewska K, Cephus J, Reiss S, Bates JT, Crowe JE, Boyd KL, Moore ML, Zhou W, Peebles RS (2014) J Virol 88: 9655-72 Transforming growth factor beta is a major regulator of human neonatal immune responses following respiratory syncytial virus infection. Thornburg NJ, Shepherd B, Crowe JE (2010) J Virol 84: 12895-902 Respiratory syncytial virus induces host RNA stress granules to facilitate viral replication. Lindquist ME, Lifland AW, Utley TJ, Santangelo PJ, Crowe JE (2010) J Virol 84: 12274-84 A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction. Moore ML, Chi MH, Luongo C, Lukacs NW, Polosukhin VV, Huckabee MM, Newcomb DC, Buchholz UJ, Crowe JE, Goleniewska K, Williams JV, Collins PL, Peebles RS (2009) J Virol 83: 4185-94 Venezuelan equine encephalitis virus replicon particles encoding respiratory syncytial virus surface glycoproteins induce protective mucosal responses in mice and cotton rats. Mok H, Lee S, Utley TJ, Shepherd BE, Polosukhin VV, Collier ML, Davis NL, Johnston RE, Crowe JE (2007) J Virol 81: 13710-22 Human antibody responses to mature and immature forms of viral envelope in respiratory syncytial virus infection: significance for subunit vaccines. Sakurai H, Williamson RA, Crowe JE, Beeler JA, Poignard P, Bastidas RB, Chanock RM, Burton DR (1999) J Virol 73: 2956-62 NK T cells contribute to expansion of CD8(+) T cells and amplification of antiviral immune responses to respiratory syncytial virus. Johnson TR, Hong S, Van Kaer L, Koezuka Y, Graham BS (2002) J Virol 76: 4294-303 Tissue-specific regulation of CD8+ T-lymphocyte immunodominance in respiratory syncytial virus infection. Lee S, Miller SA, Wright DW, Rock MT, Crowe JE (2007) J Virol 81: 2349-58 Human respiratory syncytial virus nucleoprotein and inclusion bodies antagonize the innate immune response mediated by MDA5 and MAVS. Lifland AW, Jung J, Alonas E, Zurla C, Crowe JE, Santangelo PJ (2012) J Virol 86: 8245-58
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