Influenza H7N9 Virus Neuraminidase-Specific Human Monoclonal Antibodies Inhibit Viral Egress and Protect from Lethal Influenza Infection in Mice. Gilchuk IM, Bangaru S, Gilchuk P, Irving RP, Kose N, Bombardi RG, Thornburg NJ, Creech CB, Edwards KM, Li S, Turner HL, Yu W, Zhu X, Wilson IA, Ward AB, Crowe JE (2019) Cell Host Microbe 26: 715-728.e8 Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia. McAuley JL, Hornung F, Boyd KL, Smith AM, McKeon R, Bennink J, Yewdell JW, McCullers JA (2007) Cell Host Microbe 2: 240-9 Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies. Zhu X, Turner HL, Lang S, McBride R, Bangaru S, Gilchuk IM, Yu W, Paulson JC, Crowe JE, Ward AB, Wilson IA (2019) Cell Host Microbe 26: 729-738.e4 Glycan shielding of the influenza virus hemagglutinin contributes to immunopathology in mice. Wanzeck K, Boyd KL, McCullers JA (2011) Am J Respir Crit Care Med 183: 767-73 CD154 regulates primate humoral immunity to influenza. Crowe JE, Sannella EC, Pfeiffer S, Zorn GL, Azimzadeh A, Newman R, Miller GG, Pierson RN (2003) Am J Transplant 3: 680-8 Toll-like receptor 2 mediates fatal immunopathology in mice during treatment of secondary pneumococcal pneumonia following influenza. Karlström A, Heston SM, Boyd KL, Tuomanen EI, McCullers JA (2011) J Infect Dis 204: 1358-66 Treatment with protein synthesis inhibitors improves outcomes of secondary bacterial pneumonia after influenza. Karlström A, Boyd KL, English BK, McCullers JA (2009) J Infect Dis 199: 311-9 Influenza enhances susceptibility to natural acquisition of and disease due to Streptococcus pneumoniae in ferrets. McCullers JA, McAuley JL, Browall S, Iverson AR, Boyd KL, Henriques Normark B (2010) J Infect Dis 202: 1287-95 Unveiling the burden of influenza-associated pneumococcal pneumonia. Grijalva CG, Griffin MR (2012) J Infect Dis 205: 355-7 CD8+ T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo. Assarsson E, Kambayashi T, Sandberg JK, Hong S, Taniguchi M, Van Kaer L, Ljunggren HG, Chambers BJ (2000) J Immunol 165: 3673-9 Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses. Krause JC, Tsibane T, Tumpey TM, Huffman CJ, Albrecht R, Blum DL, Ramos I, Fernandez-Sesma A, Edwards KM, García-Sastre A, Basler CF, Crowe JE (2012) J Virol 86: 6334-40 A broadly neutralizing human monoclonal antibody that recognizes a conserved, novel epitope on the globular head of the influenza H1N1 virus hemagglutinin. Krause JC, Tsibane T, Tumpey TM, Huffman CJ, Basler CF, Crowe JE (2011) J Virol 85: 10905-8 Naturally occurring human monoclonal antibodies neutralize both 1918 and 2009 pandemic influenza A (H1N1) viruses. Krause JC, Tumpey TM, Huffman CJ, McGraw PA, Pearce MB, Tsibane T, Hai R, Basler CF, Crowe JE (2010) J Virol 84: 3127-30 Influenza viruses with receptor-binding N1 neuraminidases occur sporadically in several lineages and show no attenuation in cell culture or mice. Hooper KA, Crowe JE, Bloom JD (2015) J Virol 89: 3737-45 Immunopathogenic and antibacterial effects of H3N2 influenza A virus PB1-F2 map to amino acid residues 62, 75, 79, and 82. Alymova IV, Green AM, van de Velde N, McAuley JL, Boyd KL, Ghoneim HE, McCullers JA (2011) J Virol 85: 12324-33 Bacterial sinusitis and otitis media following influenza virus infection in ferrets. Peltola VT, Boyd KL, McAuley JL, Rehg JE, McCullers JA (2006) Infect Immun 74: 2562-7 The immune profile associated with acute allergic asthma accelerates clearance of influenza virus. Samarasinghe AE, Woolard SN, Boyd KL, Hoselton SA, Schuh JM, McCullers JA (2014) Immunol Cell Biol 92: 449-59 A chemically programmed antibody is a long-lasting and potent inhibitor of influenza neuraminidase. Hayakawa M, Toda N, Carrillo N, Thornburg NJ, Crowe JE, Barbas CF (2012) Chembiochem 13: 2191-5 Seroprevalence of seasonal and pandemic influenza A viruses in domestic cats. McCullers JA, Van De Velde LA, Schultz RD, Mitchell CG, Halford CR, Boyd KL, Schultz-Cherry S (2011) Arch Virol 156: 117-20 Chloroquine is effective against influenza A virus in vitro but not in vivo. Vigerust DJ, McCullers JA (2007) Influenza Other Respir Viruses 1: 189-92
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