Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, Chen Z, Lee MK, Attar N, Sazegar H, Chodon T, Nelson SF, McArthur G, Sosman JA, Ribas A, Lo RS (2010) Nature 468: 973-7 p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho. Wildenberg GA, Dohn MR, Carnahan RH, Davis MA, Lobdell NA, Settleman J, Reynolds AB (2006) Cell 127: 1027-39 Probing the Virtual Proteome to Identify Novel Disease Biomarkers. Mosley JD, Benson MD, Smith JG, Melander O, Ngo D, Shaffer CM, Ferguson JF, Herzig MS, McCarty CA, Chute CG, Jarvik GP, Gordon AS, Palmer MR, Crosslin DR, Larson EB, Carrell DS, Kullo IJ, Pacheco JA, Peissig PL, Brilliant MH, Kitchner TE, Linneman JG, Namjou B, Williams MS, Ritchie MD, Borthwick KM, Kiryluk K, Mentch FD, Sleiman PM, Karlson EW, Verma SS, Zhu Y, Vasan RS, Yang Q, Denny JC, Roden DM, Gerszten RE, Wang TJ (2018) Circulation 138: 2469-2481 Coexpression of phosphotyrosine-containing proteins, platelet-derived growth factor-B, and fibroblast growth factor-1 in situ in synovial tissues of patients with rheumatoid arthritis and Lewis rats with adjuvant or streptococcal cell wall arthritis. Sano H, Engleka K, Mathern P, Hla T, Crofford LJ, Remmers EF, Jelsema CL, Goldmuntz E, Maciag T, Wilder RL (1993) J Clin Invest 91: 553-65 Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. Niimura F, Labosky PA, Kakuchi J, Okubo S, Yoshida H, Oikawa T, Ichiki T, Naftilan AJ, Fogo A, Inagami T (1995) J Clin Invest 96: 2947-54 A G/C element mediates repression of the SM22alpha promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis. Wamhoff BR, Hoofnagle MH, Burns A, Sinha S, McDonald OG, Owens GK (2004) Circ Res 95: 981-8 Programming smooth muscle plasticity with chromatin dynamics. McDonald OG, Owens GK (2007) Circ Res 100: 1428-41 PDGF induction of alpha 2 integrin gene expression is mediated by protein kinase C-zeta. Xu J, Zutter MM, Santoro SA, Clark RA (1996) J Cell Biol 134: 1301-11 Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin. Erdogan B, Ao M, White LM, Means AL, Brewer BM, Yang L, Washington MK, Shi C, Franco OE, Weaver AM, Hayward SW, Li D, Webb DJ (2017) J Cell Biol 216: 3799-3816 Inflammatory myofibroblastic tumors harbor multiple potentially actionable kinase fusions. Lovly CM, Gupta A, Lipson D, Otto G, Brennan T, Chung CT, Borinstein SC, Ross JS, Stephens PJ, Miller VA, Coffin CM (2014) Cancer Discov 4: 889-95 Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B. Rivera GM, Antoku S, Gelkop S, Shin NY, Hanks SK, Pawson T, Mayer BJ (2006) Proc Natl Acad Sci U S A 103: 9536-41 Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation. Triplett TA, Cardenas KT, Lancaster JN, Hu Z, Selden HJ, Jasso GJ, Balasubramanyam S, Chan K, Li L, Chen X, Marcogliese AN, Davé UP, Love PE, Ehrlich LI (2016) Proc Natl Acad Sci U S A 113: E1016-25 Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development. Que J, Wilm B, Hasegawa H, Wang F, Bader D, Hogan BL (2008) Proc Natl Acad Sci U S A 105: 16626-30 Promises and pitfalls of anti-angiogenic therapy in clinical trials. McCarty MF, Liu W, Fan F, Parikh A, Reimuth N, Stoeltzing O, Ellis LM (2003) Trends Mol Med 9: 53-8 Internephron heterogeneity of growth factors and sclerosis--modulation of platelet-derived growth factor by angiotensin II. Tanaka R, Sugihara K, Tatematsu A, Fogo A (1995) Kidney Int 47: 131-9 The renal lesions that develop in neonatal mice during angiotensin inhibition mimic obstructive nephropathy. Miyazaki Y, Tsuchida S, Fogo A, Ichikawa I (1999) Kidney Int 55: 1683-95 Renal fibrosis is not reduced by blocking transforming growth factor-β signaling in matrix-producing interstitial cells. Neelisetty S, Alford C, Reynolds K, Woodbury L, Nlandu-Khodo S, Yang H, Fogo AB, Hao CM, Harris RC, Zent R, Gewin L (2015) Kidney Int 88: 503-14 Phase II study of neoadjuvant imatinib in glioblastoma: evaluation of clinical and molecular effects of the treatment. Razis E, Selviaridis P, Labropoulos S, Norris JL, Zhu MJ, Song DD, Kalebic T, Torrens M, Kalogera-Fountzila A, Karkavelas G, Karanastasi S, Fletcher JA, Fountzilas G (2009) Clin Cancer Res 15: 6258-66 The effect of the local delivery of platelet-derived growth factor from reactive two-component polyurethane scaffolds on the healing in rat skin excisional wounds. Li B, Davidson JM, Guelcher SA (2009) Biomaterials 30: 3486-94 PDGF, CSF-1, and EGF induce tyrosine phosphorylation of p120, a pp60src transformation-associated substrate. Downing JR, Reynolds AB (1991) Oncogene 6: 607-13 Mechanisms of oncogene cooperation: activation and inactivation of a growth antagonist. Ragozzino MM, Kuo A, DeGregori J, Kohl N, Ruley HE (1991) Environ Health Perspect 93: 97-103 PDGFRB-rearranged T-lymphoblastic leukemia/lymphoma occurring with myeloid neoplasms: the missing link supporting a stem cell origin. Ondrejka SL, Jegalian AG, Kim AS, Chabot-Richards DS, Giltnane J, Czuchlewski DR, Shetty S, Sekeres MA, Yenamandra A, Head D, Jagasia M, Hsi ED (2014) Haematologica 99: e148-51 Sustained microgravity reduces intrinsic wound healing and growth factor responses in the rat. Davidson JM, Aquino AM, Woodward SC, Wilfinger WW (1999) FASEB J 13: 325-9 Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity. Schroeder MC, Hamby JM, Connolly CJ, Grohar PJ, Winters RT, Barvian MR, Moore CW, Boushelle SL, Crean SM, Kraker AJ, Driscoll DL, Vincent PW, Elliott WL, Lu GH, Batley BL, Dahring TK, Major TC, Panek RL, Doherty AM, Showalter HD (2001) J Med Chem 44: 1915-26 Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells. Kanner SB, Reynolds AB, Parsons JT (1991) Mol Cell Biol 11: 713-20 Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity. Gould KL, Hunter T (1988) Mol Cell Biol 8: 3345-56 Multicenter Phase II trial of high-dose imatinib mesylate in metastatic melanoma: significant toxicity with no clinical efficacy. Wyman K, Atkins MB, Prieto V, Eton O, McDermott DF, Hubbard F, Byrnes C, Sanders K, Sosman JA (2006) Cancer 106: 2005-11 Injectable biodegradable polyurethane scaffolds with release of platelet-derived growth factor for tissue repair and regeneration. Hafeman AE, Li B, Yoshii T, Zienkiewicz K, Davidson JM, Guelcher SA (2008) Pharm Res 25: 2387-99 Basic fibroblast growth factor: a potential mediator of stromal growth in the human prostate. Sherwood ER, Fong CJ, Lee C, Kozlowski JM (1992) Endocrinology 130: 2955-63 Proteinases are isoform-specific regulators of the binding of transforming growth factor beta to alpha 2-macroglobulin. Webb DJ, Weaver AM, Atkins-Brady TL, Gonias SL (1996) Biochem J 320 ( Pt 2): 551-5 The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase. Tsuboi N, Utsunomiya T, Roberts RL, Ito H, Takahashi K, Noda M, Takahashi T (2008) Biochem J 413: 193-200 Native and activated forms of alpha 2-macroglobulin increase expression of platelet-derived growth factor alpha-receptor in vascular smooth muscle cells. Evidence for autocrine transforming growth factor-beta activity. Weaver AM, Owens GK, Gonias SL (1995) J Biol Chem 270: 30741-8 Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling. Rameh LE, Rhee SG, Spokes K, Kazlauskas A, Cantley LC, Cantley LG (1998) J Biol Chem 273: 23750-7 Epidermal growth factor and platelet-derived growth factor-BB induce a stable increase in the activity of low density lipoprotein receptor-related protein in vascular smooth muscle cells by altering receptor distribution and recycling. Weaver AM, McCabe M, Kim I, Allietta MM, Gonias SL (1996) J Biol Chem 271: 24894-900 Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells. Komalavilas P, Shah PK, Jo H, Lincoln TM (1999) J Biol Chem 274: 34301-9 Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression. Liu Y, Sinha S, McDonald OG, Shang Y, Hoofnagle MH, Owens GK (2005) J Biol Chem 280: 9719-27
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