Elucidating mechanisms of drug-induced toxicity. Liebler DC, Guengerich FP (2005) Nat Rev Drug Discov 4: 410-20 The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4. Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG, Kim RB (2003) Nat Med 9: 220-4 The structural basis of HLA-associated drug hypersensitivity syndromes. Pompeu YA, Stewart JD, Mallal S, Phillips E, Peters B, Ostrov DA (2012) Immunol Rev 250: 158-66 Inhibition of human cytochrome P450-catalyzed oxidations of xenobiotics and procarcinogens by synthetic organoselenium compounds. Shimada T, El-Bayoumy K, Upadhyaya P, Sutter TR, Guengerich FP, Yamazaki H (1997) Cancer Res 57: 4757-64 Purification and characterization of xenobiotic-metabolizing enzymes from lung tissue. Guengerich FP (1990) Pharmacol Ther 45: 299-307 Cytochromes P450, drugs, and diseases. Guengerich FP (2003) Mol Interv 3: 194-204 New applications of bacterial systems to problems in toxicology. Guengerich FP, Gillam EM, Shimada T (1996) Crit Rev Toxicol 26: 551-83 Cytochrome P450: what have we learned and what are the future issues? Guengerich FP (2004) Drug Metab Rev 36: 159-97 Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Huang W, Zhang J, Washington M, Liu J, Parant JM, Lozano G, Moore DD (2005) Mol Endocrinol 19: 1646-53 Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications. Li Z, Jiang Y, Guengerich FP, Ma L, Li S, Zhang W (2020) J Biol Chem 295: 833-849 Transcriptional ontogeny of the developing liver. Lee JS, Ward WO, Knapp G, Ren H, Vallanat B, Abbott B, Ho K, Karp SJ, Corton JC (2012) BMC Genomics 13: 33 Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102. Lewis DF, Lake BG, George SG, Dickins M, Eddershaw PJ, Tarbit MH, Beresford AP, Goldfarb PS, Guengerich FP (1999) Toxicology 139: 53-79 Inter-individual differences in the metabolism of environmental toxicants: cytochrome P450 1A2 as a prototype. Guengerich FP, Parikh A, Turesky RJ, Josephy PD (1999) Mutat Res 428: 115-24 Intersection of the Roles of Cytochrome P450 Enzymes with Xenobiotic and Endogenous Substrates: Relevance to Toxicity and Drug Interactions. Guengerich FP (2017) Chem Res Toxicol 30: 2-12 Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. Guengerich FP (2001) Chem Res Toxicol 14: 611-50 Protein damage by reactive electrophiles: targets and consequences. Liebler DC (2008) Chem Res Toxicol 21: 117-28 The poisons within: application of toxicity mechanisms to fundamental disease processes. Liebler DC (2006) Chem Res Toxicol 19: 610-3 Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals. Rendic S, Guengerich FP (2015) Chem Res Toxicol 28: 38-42 Oxidation of xenobiotics by recombinant human cytochrome P450 1B1. Shimada T, Gillam EM, Sutter TR, Strickland PT, Guengerich FP, Yamazaki H (1997) Drug Metab Dispos 25: 617-22 Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone. Przybysz AJ, Choe KP, Roberts LJ, Strange K (2009) Mech Ageing Dev 130: 357-69 Variation in xenobiotic transport and metabolism genes, household chemical exposures, and risk of childhood acute lymphoblastic leukemia. Chokkalingam AP, Metayer C, Scelo GA, Chang JS, Urayama KY, Aldrich MC, Guha N, Hansen HM, Dahl GV, Barcellos LF, Wiencke JK, Wiemels JL, Buffler PA (2012) Cancer Causes Control 23: 1367-75 Effects of nonylphenol, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE), and pentachlorophenol on the adult female guinea pig reproductive tract. Danzo BJ, Shappell HW, Banerjee A, Hachey DL (2002) Reprod Toxicol 16: 29-43 Streptomyces cytochromes P450: applications in drug metabolism. Lamb DC, Waterman MR, Zhao B (2013) Expert Opin Drug Metab Toxicol 9: 1279-94 Inter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations. Yamazaki H, Okayama A, Imai N, Guengerich FP, Shimizu M (2006) Xenobiotica 36: 1201-9 Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli. Yamazaki H, Nakamura M, Komatsu T, Ohyama K, Hatanaka N, Asahi S, Shimada N, Guengerich FP, Shimada T, Nakajima M, Yokoi T (2002) Protein Expr Purif 24: 329-37 Life and times in biochemical toxicology. Guengerich FP (2005) Int J Toxicol 24: 5-21
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