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Connections to Hydroxylation are shown below. Double-click or tap a node for more information.
Please note that publication matches are limited to 40 in this view. If you expected more, please view all publication matches for Hydroxylation.
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- VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.
Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, Liu XD, Jonasch E, Xie L, Chen X, Yao X, Teh BT, Tan P, Zheng X, Li M, Lawrence C, Fan J, Geng J, Liu X, Hu L, Wang J, Liao C, Hong K, Zurlo G, Parker JS, Auman JT, Perou CM, Rathmell WK, Kim WY, Kirschner MW, Kaelin WG, Baldwin AS, Zhang Q
(2018) Science 361: 290-295 - Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG, Zhang Q
(2014) Genes Dev 28: 1429-44 - Biological role of prolyl 3-hydroxylation in type IV collagen.
Pokidysheva E, Boudko S, Vranka J, Zientek K, Maddox K, Moser M, Fässler R, Ware J, Bächinger HP
(2014) Proc Natl Acad Sci U S A 111: 161-6 - Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: association of polymorphisms with functional differences in estrogen hydroxylation activity.
Hanna IH, Dawling S, Roodi N, Guengerich FP, Parl FF
(2000) Cancer Res 60: 3440-4 - Roles of human liver cytochrome P4502C and 3A enzymes in the 3-hydroxylation of benzo(a)pyrene.
Yun CH, Shimada T, Guengerich FP
(1992) Cancer Res 52: 1868-74 - Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development.
Kobayashi H, Liu J, Urrutia AA, Burmakin M, Ishii K, Rajan M, Davidoff O, Saifudeen Z, Haase VH
(2017) Kidney Int 92: 1370-1383 - Genetic polymorphism of S-mephenytoin hydroxylation.
Wilkinson GR, Guengerich FP, Branch RA
(1989) Pharmacol Ther 43: 53-76 - Scleroderma is associated with differences in individual routes of drug metabolism: a study with dapsone, debrisoquin, and mephenytoin.
May DG, Black CM, Olsen NJ, Csuka ME, Tanner SB, Bellino L, Porter JA, Wilkinson GR, Branch RA
(1990) Clin Pharmacol Ther 48: 286-95 - Unusual properties of the cytochrome P450 superfamily.
Lamb DC, Waterman MR
(2013) Philos Trans R Soc Lond B Biol Sci 368: 20120434 - Mechanisms of cytochrome P-450 catalysis.
Guengerich FP, MacDonald TL
(1990) FASEB J 4: 2453-9 - Catalytic properties of polymorphic human cytochrome P450 1B1 variants.
Shimada T, Watanabe J, Kawajiri K, Sutter TR, Guengerich FP, Gillam EM, Inoue K
(1999) Carcinogenesis 20: 1607-13 - The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines.
Yueh MF, Nguyen N, Famourzadeh M, Strassburg CP, Oda Y, Guengerich FP, Tukey RH
(2001) Carcinogenesis 22: 943-50 - In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds.
Mast N, Verwilst P, Wilkey CJ, Guengerich FP, Pikuleva IA
(2020) J Med Chem 63: 6477-6488 - Cupric-amyloid beta peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical.
Dikalov SI, Vitek MP, Mason RP
(2004) Free Radic Biol Med 36: 340-7 - Comments on prostaglandin F2 alpha rises in response to hydroxyl radical generated in vivo.
Awad J, Morrow J, Roberts LJ
(1995) Free Radic Biol Med 19: 944-6 - Early determinants of H2O2-induced endothelial dysfunction.
Boulden BM, Widder JD, Allen JC, Smith DA, Al-Baldawi RN, Harrison DG, Dikalov SI, Jo H, Dudley SC
(2006) Free Radic Biol Med 41: 810-7 - Propagation of protein glycation damage involves modification of tryptophan residues via reactive oxygen species: inhibition by pyridoxamine.
Chetyrkin SV, Mathis ME, Ham AJ, Hachey DL, Hudson BG, Voziyan PA
(2008) Free Radic Biol Med 44: 1276-85 - Comprehensive Characterization of Glycosylation and Hydroxylation of Basement Membrane Collagen IV by High-Resolution Mass Spectrometry.
Basak T, Vega-Montoto L, Zimmerman LJ, Tabb DL, Hudson BG, Vanacore RM
(2016) J Proteome Res 15: 245-58 - Cytochrome P450-type hydroxylation and epoxidation in a tyrosine-liganded hemoprotein, catalase-related allene oxide synthase.
Boeglin WE, Brash AR
(2012) J Biol Chem 287: 24139-47 - Cytochrome P450 7A1 cholesterol 7alpha-hydroxylation: individual reaction steps in the catalytic cycle and rate-limiting ferric iron reduction.
Shinkyo R, Guengerich FP
(2011) J Biol Chem 286: 4632-43 - Electron transport pathway for a Streptomyces cytochrome P450: cytochrome P450 105D5-catalyzed fatty acid hydroxylation in Streptomyces coelicolor A3(2).
Chun YJ, Shimada T, Sanchez-Ponce R, Martin MV, Lei L, Zhao B, Kelly SL, Waterman MR, Lamb DC, Guengerich FP
(2007) J Biol Chem 282: 17486-500 - Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4.
Cheng Q, Sohl CD, Yoshimoto FK, Guengerich FP
(2012) J Biol Chem 287: 29554-67 - Mechanism of 17α,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1: 18O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN.
Yoshimoto FK, Gonzalez E, Auchus RJ, Guengerich FP
(2016) J Biol Chem 291: 17143-64 - Cytochrome P-450-catalyzed hydroxylation and carboxylic acid ester cleavage of Hantzsch pyridine esters.
Guengerich FP, Peterson LA, Böcker RH
(1988) J Biol Chem 263: 8176-83 - Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE.
Pallan PS, Wang C, Lei L, Yoshimoto FK, Auchus RJ, Waterman MR, Guengerich FP, Egli M
(2015) J Biol Chem 290: 13128-43 - Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates -retinol to 3,4-dehydroretinol.
Johnson KM, Phan TTN, Albertolle ME, Guengerich FP
(2017) J Biol Chem 292: 13672-13687 - The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands.
Cowart LA, Wei S, Hsu MH, Johnson EF, Krishna MU, Falck JR, Capdevila JH
(2002) J Biol Chem 277: 35105-12 - Purification and in vitro DNA-binding specificity of the Bacillus subtilis phage phi 105 repressor.
Van Kaer L, Van Montagu M, Dhaese P
(1989) J Biol Chem 264: 14784-91 - Unusual cytochrome p450 enzymes and reactions.
Guengerich FP, Munro AW
(2013) J Biol Chem 288: 17065-73 - Activation mechanism of Gi and Go by reactive oxygen species.
Nishida M, Schey KL, Takagahara S, Kontani K, Katada T, Urano Y, Nagano T, Nagao T, Kurose H
(2002) J Biol Chem 277: 9036-42 - Cytochrome P450 3A4-catalyzed testosterone 6beta-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps.
Krauser JA, Guengerich FP
(2005) J Biol Chem 280: 19496-506 - Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6.
Yun CH, Kim KH, Calcutt MW, Guengerich FP
(2005) J Biol Chem 280: 12279-91 - Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes.
Yamazaki H, Inoue K, Chiba K, Ozawa N, Kawai T, Suzuki Y, Goldstein JA, Guengerich FP, Shimada T
(1998) Biochem Pharmacol 56: 243-51 - Digitoxin metabolism by rat liver microsomes.
Schmoldt A, Benthe HF, Haberland G
(1975) Biochem Pharmacol 24: 1639-41 - Synthesis and reactivity of some 6-substituted-2,4-dimethyl-3-pyridinols, a novel class of chain-breaking antioxidants.
Wijtmans M, Pratt DA, Brinkhorst J, Serwa R, Valgimigli L, Pedulli GF, Porter NA
(2004) J Org Chem 69: 9215-23 - Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons.
Zhang J, Perry G, Smith MA, Robertson D, Olson SJ, Graham DG, Montine TJ
(1999) Am J Pathol 154: 1423-9 - Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4.
Fleming CM, Branch RA, Wilkinson GR, Guengerich FP
(1992) Mol Pharmacol 41: 975-80 - Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction.
Teder T, Boeglin WE, Brash AR
(2014) J Lipid Res 55: 2587-96 - Novel transformations of HPETEs by cytochrome P450s.
Brash AR, Chang MS, Funk CD, Song W
(1994) Ann N Y Acad Sci 744: 25-30 - Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in human hepatic microsomes by ipomeanol analogs--an exploratory study.
Nunes MG, Desai D, Koehl W, Spratt TE, Guengerich FP, Amin S
(1998) Cancer Lett 129: 131-8
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