Rational use of analgesic and antiinflammatory drugs. Crofford LJ (2001) N Engl J Med 345: 1844-6 Contribution of cyclooxygenase-2 to elevated biosynthesis of thromboxane A2 and prostacyclin in cigarette smokers. McAdam BF, Byrne D, Morrow JD, Oates JA (2005) Circulation 112: 1024-9 Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice. Babaev VR, Ding L, Reese J, Morrow JD, Breyer MD, Dey SK, Fazio S, Linton MF (2006) Circulation 113: 108-17 Nonsteroidal anti-inflammatory drug use, chronic liver disease, and hepatocellular carcinoma. Sahasrabuddhe VV, Gunja MZ, Graubard BI, Trabert B, Schwartz LM, Park Y, Hollenbeck AR, Freedman ND, McGlynn KA (2012) J Natl Cancer Inst 104: 1808-14 Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II. Qi Z, Hao CM, Langenbach RI, Breyer RM, Redha R, Morrow JD, Breyer MD (2002) J Clin Invest 110: 61-9 Host cyclooxygenase-2 modulates carcinoma growth. Williams CS, Tsujii M, Reese J, Dey SK, DuBois RN (2000) J Clin Invest 105: 1589-94 Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. Sheng H, Shao J, Kirkland SC, Isakson P, Coffey RJ, Morrow J, Beauchamp RD, DuBois RN (1997) J Clin Invest 99: 2254-9 Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation. Cha YI, Kim SH, Sepich D, Buchanan FG, Solnica-Krezel L, DuBois RN (2006) Genes Dev 20: 77-86 ω-Alkynyl lipid surrogates for polyunsaturated fatty acids: free radical and enzymatic oxidations. Beavers WN, Serwa R, Shimozu Y, Tallman KA, Vaught M, Dalvie ED, Marnett LJ, Porter NA (2014) J Am Chem Soc 136: 11529-39 Coordinated regulation of fetal and maternal prostaglandins directs successful birth and postnatal adaptation in the mouse. Reese J, Paria BC, Brown N, Zhao X, Morrow JD, Dey SK (2000) Proc Natl Acad Sci U S A 97: 9759-64 Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages. Chen X, Barozzi I, Termanini A, Prosperini E, Recchiuti A, Dalli J, Mietton F, Matteoli G, Hiebert S, Natoli G (2012) Proc Natl Acad Sci U S A 109: E2865-74 Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases. Boutaud O, Aronoff DM, Richardson JH, Marnett LJ, Oates JA (2002) Proc Natl Acad Sci U S A 99: 7130-5 Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system. Kirkby NS, Lundberg MH, Harrington LS, Leadbeater PD, Milne GL, Potter CM, Al-Yamani M, Adeyemi O, Warner TD, Mitchell JA (2012) Proc Natl Acad Sci U S A 109: 17597-602 Cyclooxygenase enzymes: catalysis and inhibition. Kurumbail RG, Kiefer JR, Marnett LJ (2001) Curr Opin Struct Biol 11: 752-60 Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer. Daikoku T, Tranguch S, Chakrabarty A, Wang D, Khabele D, Orsulic S, Morrow JD, Dubois RN, Dey SK (2007) Cancer Res 67: 5285-92 Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney. Schneider A, Zhang Y, Zhang M, Lu WJ, Rao R, Fan X, Redha R, Davis L, Breyer RM, Harris R, Guan Y, Breyer MD (2004) Kidney Int 65: 1205-13 Cyclooxygenase-2-selective inhibitors impair glomerulogenesis and renal cortical development. Kömhoff M, Wang JL, Cheng HF, Langenbach R, McKanna JA, Harris RC, Breyer MD (2000) Kidney Int 57: 414-22 The role of cyclooxygenases in inflammation, cancer, and development. Williams CS, Mann M, DuBois RN (1999) Oncogene 18: 7908-16 Prostaglandin E2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice. Tanaka K, Furuyashiki T, Kitaoka S, Senzai Y, Imoto Y, Segi-Nishida E, Deguchi Y, Breyer RM, Breyer MD, Narumiya S (2012) J Neurosci 32: 4319-29 Suboptimal inhibition of platelet cyclooxygenase-1 by aspirin in metabolic syndrome. Smith JP, Haddad EV, Taylor MB, Oram D, Blakemore D, Chen Q, Boutaud O, Oates JA (2012) Hypertension 59: 719-25 Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer. Wilson AJ, Fadare O, Beeghly-Fadiel A, Son DS, Liu Q, Zhao S, Saskowski J, Uddin MJ, Daniel C, Crews B, Lehmann BD, Pietenpol JA, Crispens MA, Marnett LJ, Khabele D (2015) Oncotarget 6: 21353-68 Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis. Holinstat M, Boutaud O, Apopa PL, Vesci J, Bala M, Oates JA, Hamm HE (2011) Arterioscler Thromb Vasc Biol 31: 435-42 Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipoprotein cholesterol in vitro. Smith LH, Boutaud O, Breyer M, Morrow JD, Oates JA, Vaughan DE (2002) Arterioscler Thromb Vasc Biol 22: 983-8 Inflammatory modulation and wound repair. Davidson JM, Breyer MD (2003) J Invest Dermatol 120: xi-xii 12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity. Yeung J, Apopa PL, Vesci J, Stolla M, Rai G, Simeonov A, Jadhav A, Fernandez-Perez P, Maloney DJ, Boutaud O, Holman TR, Holinstat M (2013) Thromb Haemost 110: 569-81 Cyclooxygenase in biology and disease. Dubois RN, Abramson SB, Crofford L, Gupta RA, Simon LS, Van De Putte LB, Lipsky PE (1998) FASEB J 12: 1063-73 Meloxicam inhibits the growth of colorectal cancer cells. Goldman AP, Williams CS, Sheng H, Lamps LW, Williams VP, Pairet M, Morrow JD, DuBois RN (1998) Carcinogenesis 19: 2195-9 Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. Shao J, Sheng H, Aramandla R, Pereira MA, Lubet RA, Hawk E, Grogan L, Kirsch IR, Washington MK, Beauchamp RD, DuBois RN (1999) Carcinogenesis 20: 185-91 Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. Kalgutkar AS, Marnett AB, Crews BC, Remmel RP, Marnett LJ (2000) J Med Chem 43: 2860-70 Stereoselective binding of indomethacin ethanolamide derivatives to cyclooxygenase-1. Moth CW, Prusakiewicz JJ, Marnett LJ, Lybrand TP (2005) J Med Chem 48: 3613-20 Structural and functional basis of cyclooxygenase inhibition. Blobaum AL, Marnett LJ (2007) J Med Chem 50: 1425-41 Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold. Liedtke AJ, Crews BC, Daniel CM, Blobaum AL, Kingsley PJ, Ghebreselasie K, Marnett LJ (2012) J Med Chem 55: 2287-300 Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice. Kojima F, Kapoor M, Yang L, Fleishaker EL, Ward MR, Monrad SU, Kottangada PC, Pace CQ, Clark JA, Woodward JG, Crofford LJ (2008) J Immunol 180: 8361-8 Biphenotypic B/macrophage cells express COX-1 and up-regulate COX-2 expression and prostaglandin E(2) production in response to pro-inflammatory signals. Graf BA, Nazarenko DA, Borrello MA, Roberts LJ, Morrow JD, Palis J, Phipps RP (1999) Eur J Immunol 29: 3793-803 Expression of cyclooxygenase-2 and prostaglandins by B-1 cells and B-CLL cells. Phipps RP, Pollock SJ, Kaur K, Kaufman J, Borrello MA, Graf BA, Nazarenko D, Roberts LJ, Morrow JD, Palis J, Ryan DJ, Bennett JM (2000) Curr Top Microbiol Immunol 252: 293-300 Cyclooxygenase inhibition and thrombogenicity. Catella-Lawson F, Crofford LJ (2001) Am J Med 110 Suppl 3A: 28S-32S Prostaglandin-Endoperoxide Synthase 1 Mediates the Timing of Parturition in Mice Despite Unhindered Uterine Contractility. Herington JL, O'Brien C, Robuck MF, Lei W, Brown N, Slaughter JC, Paria BC, Mahadevan-Jansen A, Reese J (2018) Endocrinology 159: 490-505 Comparative analysis of pharmacologic and/or genetic disruption of cyclooxygenase-1 and cyclooxygenase-2 function in female reproduction in mice. Reese J, Zhao X, Ma WG, Brown N, Maziasz TJ, Dey SK (2001) Endocrinology 142: 3198-206 Regulation of cyclooxygenase expression by vasopressin in rat renal medulla. Zhang MZ, Sanchez Lopez P, McKanna JA, Harris RC (2004) Endocrinology 145: 1402-9 Human cyclo-oxygenase-1 and an alternative splice variant: contrasts in expression of mRNA, protein and catalytic activities. Schneider C, Boeglin WE, Brash AR (2005) Biochem J 385: 57-64
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.