β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, Cowan CA, Spiegelman BM, Gerszten RE (2014) Cell Metab 19: 96-108 Changes in pulmonary vascular tone during exercise. Effects of nitric oxide (NO) synthase inhibition, L-arginine infusion, and NO inhalation. Koizumi T, Gupta R, Banerjee M, Newman JH (1994) J Clin Invest 94: 2275-82 Effect of prior exercise on the partitioning of an intestinal glucose load between splanchnic bed and skeletal muscle. Hamilton KS, Gibbons FK, Bracy DP, Lacy DB, Cherrington AD, Wasserman DH (1996) J Clin Invest 98: 125-35 Clearance of filtered fluid from the lung during exercise: role of hyperpnea. Koizumi T, Roselli RJ, Parker RE, Hermo-Weiler CI, Banerjee M, Newman JH (2001) Am J Respir Crit Care Med 163: 614-8 Kir6.2 is required for adaptation to stress. Zingman LV, Hodgson DM, Bast PH, Kane GC, Perez-Terzic C, Gumina RJ, Pucar D, Bienengraeber M, Dzeja PP, Miki T, Seino S, Alekseev AE, Terzic A (2002) Proc Natl Acad Sci U S A 99: 13278-83 Reduced Nonexercise Activity Attenuates Negative Energy Balance in Mice Engaged in Voluntary Exercise. Lark DS, Kwan JR, McClatchey PM, James MN, James FD, Lighton JRB, Lantier L, Wasserman DH (2018) Diabetes 67: 831-840 Hexokinase II overexpression improves exercise-stimulated but not insulin-stimulated muscle glucose uptake in high-fat-fed C57BL/6J mice. Fueger PT, Bracy DP, Malabanan CM, Pencek RR, Granner DK, Wasserman DH (2004) Diabetes 53: 306-14 Suppression of endogenous glucose production by mild hyperinsulinemia during exercise is determined predominantly by portal venous insulin. Camacho RC, Pencek RR, Lacy DB, James FD, Wasserman DH (2004) Diabetes 53: 285-93 Exercise-induced changes in insulin and glucagon are not required for enhanced hepatic glucose uptake after exercise but influence the fate of glucose within the liver. Pencek RR, James FD, Lacy DB, Jabbour K, Williams PE, Fueger PT, Wasserman DH (2004) Diabetes 53: 3041-7 Impact of insulin deficiency on glucose fluxes and muscle glucose metabolism during exercise. Wasserman DH, Mohr T, Kelly P, Lacy DB, Bracy D (1992) Diabetes 41: 1229-38 SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient- and exercise-induced stress. Vassilopoulos A, Pennington JD, Andresson T, Rees DM, Bosley AD, Fearnley IM, Ham A, Flynn CR, Hill S, Rose KL, Kim HS, Deng CX, Walker JE, Gius D (2014) Antioxid Redox Signal 21: 551-64 Can having fun protect you from obesity and its cancer risk? Collins S (2012) Pigment Cell Melanoma Res 25: 2-3 AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity. Lantier L, Fentz J, Mounier R, Leclerc J, Treebak JT, Pehmøller C, Sanz N, Sakakibara I, Saint-Amand E, Rimbaud S, Maire P, Marette A, Ventura-Clapier R, Ferry A, Wojtaszewski JF, Foretz M, Viollet B (2014) FASEB J 28: 3211-24 Endogenous cannabinoid signaling is required for voluntary exercise-induced enhancement of progenitor cell proliferation in the hippocampus. Hill MN, Titterness AK, Morrish AC, Carrier EJ, Lee TT, Gil-Mohapel J, Gorzalka BB, Hillard CJ, Christie BR (2010) Hippocampus 20: 513-23 Obesity impairs skeletal muscle AMPK signaling during exercise: role of AMPKα2 in the regulation of exercise capacity in vivo. Lee-Young RS, Ayala JE, Fueger PT, Mayes WH, Kang L, Wasserman DH (2011) Int J Obes (Lond) 35: 982-9 Physiologic action of glucagon on liver glucose metabolism. Ramnanan CJ, Edgerton DS, Kraft G, Cherrington AD (2011) Diabetes Obes Metab 13 Suppl 1: 118-25 The glucagon-like peptide-1 receptor regulates endogenous glucose production and muscle glucose uptake independent of its incretin action. Ayala JE, Bracy DP, James FD, Julien BM, Wasserman DH, Drucker DJ (2009) Endocrinology 150: 1155-64 Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice. Hughey CC, James FD, Bracy DP, Donahue EP, Young JD, Viollet B, Foretz M, Wasserman DH (2017) J Biol Chem 292: 20125-20140 Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo. Lee-Young RS, Griffee SR, Lynes SE, Bracy DP, Ayala JE, McGuinness OP, Wasserman DH (2009) J Biol Chem 284: 23925-34 Control of exercise-stimulated muscle glucose uptake by GLUT4 is dependent on glucose phosphorylation capacity in the conscious mouse. Fueger PT, Hess HS, Posey KA, Bracy DP, Pencek RR, Charron MJ, Wasserman DH (2004) J Biol Chem 279: 50956-61 Exercise training does not correct abnormal cardiac glycogen accumulation in the db/db mouse model of type 2 diabetes. Shearer J, Ross KD, Hughey CC, Johnsen VL, Hittel DS, Severson DL (2011) Am J Physiol Endocrinol Metab 301: E31-9 Role of carotid bodies in control of the neuroendocrine response to exercise. Koyama Y, Coker RH, Denny JC, Lacy DB, Jabbour K, Williams PE, Wasserman DH (2001) Am J Physiol Endocrinol Metab 281: E742-8 Heart-type fatty acid-binding protein reciprocally regulates glucose and fatty acid utilization during exercise. Shearer J, Fueger PT, Rottman JN, Bracy DP, Binas B, Wasserman DH (2005) Am J Physiol Endocrinol Metab 288: E292-7 Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARalpha and FGF21 transcripts in vivo. Berglund ED, Kang L, Lee-Young RS, Hasenour CM, Lustig DG, Lynes SE, Donahue EP, Swift LL, Charron MJ, Wasserman DH (2010) Am J Physiol Endocrinol Metab 299: E607-14 Distributed control of glucose uptake by working muscles of conscious mice: roles of transport and phosphorylation. Fueger PT, Bracy DP, Malabanan CM, Pencek RR, Wasserman DH (2004) Am J Physiol Endocrinol Metab 286: E77-84 Regulation of glucose kinetics during exercise by the glucagon-like peptide-1 receptor. Burmeister MA, Bracy DP, James FD, Holt RM, Ayala J, King EM, Wasserman DH, Drucker DJ, Ayala JE (2012) J Physiol 590: 5245-55 Synergistic effect of exercise and statins on femoral strength in rats. Starnes JW, Neidre DB, Nyman JS, Roy A, Nelson MJ, Gutierrez G, Wang X (2013) Exp Gerontol 48: 751-5 CETP Expression Protects Female Mice from Obesity-Induced Decline in Exercise Capacity. Cappel DA, Lantier L, Palmisano BT, Wasserman DH, Stafford JM (2015) PLoS One 10: e0136915 Tachycardia, reduced vagal capacity, and age-dependent ventricular dysfunction arising from diminished expression of the presynaptic choline transporter. English BA, Appalsamy M, Diedrich A, Ruggiero AM, Lund D, Wright J, Keller NR, Louderback KM, Robertson D, Blakely RD (2010) Am J Physiol Heart Circ Physiol 299: H799-810 Endothelial nitric oxide synthase is central to skeletal muscle metabolic regulation and enzymatic signaling during exercise in vivo. Lee-Young RS, Ayala JE, Hunley CF, James FD, Bracy DP, Kang L, Wasserman DH (2010) Am J Physiol Regul Integr Comp Physiol 298: R1399-408 Phenotypic and molecular differences between rats selectively bred to voluntarily run high vs. low nightly distances. Roberts MD, Brown JD, Company JM, Oberle LP, Heese AJ, Toedebusch RG, Wells KD, Cruthirds CL, Knouse JA, Ferreira JA, Childs TE, Brown M, Booth FW (2013) Am J Physiol Regul Integr Comp Physiol 304: R1024-35 Potential clinical translation of juvenile rodent inactivity models to study the onset of childhood obesity. Roberts MD, Company JM, Brown JD, Toedebusch RG, Padilla J, Jenkins NT, Laughlin MH, Booth FW (2012) Am J Physiol Regul Integr Comp Physiol 303: R247-58 Triggering endogenous neuroprotective processes through exercise in models of dopamine deficiency. Zigmond MJ, Cameron JL, Leak RK, Mirnics K, Russell VA, Smeyne RJ, Smith AD (2009) Parkinsonism Relat Disord 15 Suppl 3: S42-5 Molecular correlates of spontaneous activity in non-human primates. Mitchell AC, Aldridge G, Kohler S, Stanton G, Sullivan E, Garbett K, Faludi G, Mirnics K, Cameron JL, Greenough W (2010) J Neural Transm (Vienna) 117: 1353-8 Exercise prevents hyperhomocysteinemia in a dietary folate-restricted mouse model. Neuman JC, Albright KA, Schalinske KL (2013) Nutr Res 33: 487-93 Biophysical basis of magnetic resonance imaging of small animals. Damon BM, Gore JC (2004) Methods Enzymol 385: 19-40 Beneficial Effects of Exercise on Subendothelial Matrix Stiffness are Short-Lived. Kohn JC, Bordeleau F, Miller J, Watkins HC, Modi S, Ma J, Azar J, Putnam D, Reinhart-King CA (2018) J Biomech Eng 140:
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.