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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Connections to O(6)-Methylguanine-DNA Methyltransferase are shown below. Double-click or tap a node for more information.
Please note that publication matches are limited to 40 in this view. If you expected more, please view all publication matches for O(6)-Methylguanine-DNA Methyltransferase.
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- Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase.
Chowdhury G, Cho SH, Pegg AE, Guengerich FP
(2013) Angew Chem Int Ed Engl 52: 12879-82 - Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma.
Gajewski TF, Sosman J, Gerson SL, Liu L, Dolan E, Lin S, Vokes EE
(2005) Clin Cancer Res 11: 7861-5 - Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps.
Petko Z, Ghiassi M, Shuber A, Gorham J, Smalley W, Washington MK, Schultenover S, Gautam S, Markowitz SD, Grady WM
(2005) Clin Cancer Res 11: 1203-9 - CpG island methylation in Schistosoma- and non-Schistosoma-associated bladder cancer.
Gutiérrez MI, Siraj AK, Khaled H, Koon N, El-Rifai W, Bhatia K
(2004) Mod Pathol 17: 1268-74 - Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.
Liu L, Hachey DL, Valadez G, Williams KM, Guengerich FP, Loktionova NA, Kanugula S, Pegg AE
(2004) J Biol Chem 279: 4250-9 - Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase.
Zang H, Fang Q, Pegg AE, Guengerich FP
(2005) J Biol Chem 280: 30873-81 - Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.
Liu L, Pegg AE, Williams KM, Guengerich FP
(2002) J Biol Chem 277: 37920-8 - Cloning and expression of canine O6-methylguanine-DNA methyltransferase in target cells, using gammaretroviral and lentiviral vectors.
Zaboikin M, Srinivasakumar N, Zaboikina T, Schuening F
(2004) Hum Gene Ther 15: 383-92 - Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase.
Valadez JG, Liu L, Loktionova NA, Pegg AE, Guengerich FP
(2004) Chem Res Toxicol 17: 972-82 - Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane.
Liu L, Watanabe K, Fang Q, Williams KM, Guengerich FP, Pegg AE
(2007) Chem Res Toxicol 20: 155-63 - In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice.
Cho SH, Guengerich FP
(2013) Chem Res Toxicol 26: 1765-74 - O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromomethane and bromomethyl acetate.
Liu L, Williams KM, Guengerich FP, Pegg AE
(2004) Chem Res Toxicol 17: 742-52 - Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations.
Loecken EM, Guengerich FP
(2008) Chem Res Toxicol 21: 453-8 - O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145.
Guengerich FP, Fang Q, Liu L, Hachey DL, Pegg AE
(2003) Biochemistry 42: 10965-70 - Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation.
Guengerich FP
(2005) Arch Biochem Biophys 433: 369-78 - Pharmacokinetics of O6-benzylguanine (NSC637037) and its metabolite, 8-oxo-O6-benzylguanine.
Tserng KY, Ingalls ST, Boczko EM, Spiro TP, Li X, Majka S, Gerson SL, Willson JK, Hoppel CL
(2003) J Clin Pharmacol 43: 881-93 - Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomas.
Ye C, Shrubsole MJ, Cai Q, Ness R, Grady WM, Smalley W, Cai H, Washington K, Zheng W
(2006) Oncol Rep 16: 429-35
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