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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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- Pharmacokinetics of indomethacin in the neonate. Relation of plasma indomethacin levels to response of the ductus arteriosus.
Brash AR, Hickey DE, Graham TP, Stahlman MT, Oates JA, Cotton RB
(1981) N Engl J Med 305: 67-72 - Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide.
Myers PR, Minor RL, Guerra R, Bates JN, Harrison DG
(1990) Nature 345: 161-3 - Benzodiazepines of long and short elimination half-life and the risk of hip fracture.
Ray WA, Griffin MR, Downey W
(1989) JAMA 262: 3303-7 - Etoposide kinetics in patients with obstructive jaundice.
Hande KR, Wolff SN, Greco FA, Hainsworth JD, Reed G, Johnson DH
(1990) J Clin Oncol 8: 1101-7 - Regulation of KLF4 turnover reveals an unexpected tissue-specific role of pVHL in tumorigenesis.
Gamper AM, Qiao X, Kim J, Zhang L, DeSimone MC, Rathmell WK, Wan Y
(2012) Mol Cell 45: 233-43 - Constitutively active K-cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-infected cells.
Van Dross R, Yao S, Asad S, Westlake G, Mays DJ, Barquero L, Duell S, Pietenpol JA, Browning PJ
(2005) J Natl Cancer Inst 97: 656-66 - Methemoglobinemia from sniffing butyl nitrite.
Horne MK, Waterman MR, Simon LM, Garriott JC, Foerster EH
(1979) Ann Intern Med 91: 417-8 - HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis.
Vázquez-Chantada M, Fernández-Ramos D, Embade N, Martínez-Lopez N, Varela-Rey M, Woodhoo A, Luka Z, Wagner C, Anglim PP, Finnell RH, Caballería J, Laird-Offringa IA, Gorospe M, Lu SC, Mato JM, Martínez-Chantar ML
(2010) Gastroenterology 138: 1943-53 - Transforming growth factor-beta reverses a posttranscriptional defect in elastin synthesis in a cutis laxa skin fibroblast strain.
Zhang MC, Giro M, Quaglino D, Davidson JM
(1995) J Clin Invest 95: 986-94 - Balancing cationic and hydrophobic content of PEGylated siRNA polyplexes enhances endosome escape, stability, blood circulation time, and bioactivity in vivo.
Nelson CE, Kintzing JR, Hanna A, Shannon JM, Gupta MK, Duvall CL
(2013) ACS Nano 7: 8870-80 - Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: an Adult AIDS Clinical Trials Group Study.
Ribaudo HJ, Haas DW, Tierney C, Kim RB, Wilkinson GR, Gulick RM, Clifford DB, Marzolini C, Fletcher CV, Tashima KT, Kuritzkes DR, Acosta EP, Adult AIDS Clinical Trials Group Study
(2006) Clin Infect Dis 42: 401-7 - Kinetics of N-[(4-chlorophenyl)amino]carbonyl-2,3-dihydro-1H-indene-5-sulfonamide (LY186641) in humans.
Hande KR, Kuttesch J, Hamilton M, Satterlee W, Jackson L, Grindey G, Hainsworth JD
(1990) Cancer Res 50: 3910-4 - DeltaNp73 stabilises TAp73 proteins but compromises their function due to inhibitory hetero-oligomer formation.
Slade N, Zaika AI, Erster S, Moll UM
(2004) Cell Death Differ 11: 357-60 - Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2.
Sekhar KR, Yan XX, Freeman ML
(2002) Oncogene 21: 6829-34 - The pharmacokinetics of nelfinavir and M8 during pregnancy and post partum.
van Heeswijk RP, Khaliq Y, Gallicano KD, Bourbeau M, Seguin I, Phillips EJ, Cameron DW
(2004) Clin Pharmacol Ther 76: 588-97 - EDRF: nitrosylated compound or authentic nitric oxide.
Bates JN, Harrison DG, Myers PR, Minor RL
(1991) Basic Res Cardiol 86 Suppl 2: 17-26 - Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGlu) Negative Allosteric Modulators (NAMs) Based on Functionalized Pyrazolo[1,5- a]pyrimidine-5-carboxamide and Thieno[3,2- b]pyridine-5-carboxamide Cores.
Childress ES, Wieting JM, Felts AS, Breiner MM, Long MF, Luscombe VB, Rodriguez AL, Cho HP, Blobaum AL, Niswender CM, Emmitte KA, Conn PJ, Lindsley CW
(2019) J Med Chem 62: 378-384 - Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu).
Bollinger SR, Engers DW, Panarese JD, West M, Engers JL, Loch MT, Rodriguez AL, Blobaum AL, Jones CK, Thompson Gray A, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR
(2019) J Med Chem 62: 342-358 - Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in Schizophrenics.
Garcia-Barrantes PM, Cho HP, Niswender CM, Byers FW, Locuson CW, Blobaum AL, Xiang Z, Rook JM, Conn PJ, Lindsley CW
(2015) J Med Chem 58: 7959-71 - Enhancement of dendritic cell antigen cross-presentation by CpG DNA involves type I IFN and stabilization of class I MHC mRNA.
Kuchtey J, Chefalo PJ, Gray RC, Ramachandra L, Harding CV
(2005) J Immunol 175: 2244-51 - Tapasin-/- and TAP1-/- macrophages are deficient in vacuolar alternate class I MHC (MHC-I) processing due to decreased MHC-I stability at phagolysosomal pH.
Chefalo PJ, Grandea AG, Van Kaer L, Harding CV
(2003) J Immunol 170: 5825-33 - Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design.
Kwon YD, Georgiev IS, Ofek G, Zhang B, Asokan M, Bailer RT, Bao A, Caruso W, Chen X, Choe M, Druz A, Ko SY, Louder MK, McKee K, O'Dell S, Pegu A, Rudicell RS, Shi W, Wang K, Yang Y, Alger M, Bender MF, Carlton K, Cooper JW, Blinn J, Eudailey J, Lloyd K, Parks R, Alam SM, Haynes BF, Padte NN, Yu J, Ho DD, Huang J, Connors M, Schwartz RM, Mascola JR, Kwong PD
(2016) J Virol 90: 5899-5914 - Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin.
Persons DL, Yazlovitskaya EM, Pelling JC
(2000) J Biol Chem 275: 35778-85 - A C-terminal fragment of Cyclin E, generated by caspase-mediated cleavage, is degraded in the absence of a recognizable phosphodegron.
Plesca D, Mazumder S, Gama V, Matsuyama S, Almasan A
(2008) J Biol Chem 283: 30796-803 - Effect of concomitantly administered rifampin on the pharmacokinetics and safety of atazanavir administered twice daily.
Acosta EP, Kendall MA, Gerber JG, Alston-Smith B, Koletar SL, Zolopa AR, Agarwala S, Child M, Bertz R, Hosey L, Haas DW
(2007) Antimicrob Agents Chemother 51: 3104-10 - The role of macrophage leptin receptor in aortic root lesion formation.
Surmi BK, Atkinson RD, Gruen ML, Coenen KR, Hasty AH
(2008) Am J Physiol Endocrinol Metab 294: E488-95 - Synthesis and pharmacological characterization of a novel sigma receptor ligand with improved metabolic stability and antagonistic effects against methamphetamine.
Seminerio MJ, Robson MJ, Abdelazeem AH, Mesangeau C, Jamalapuram S, Avery BA, McCurdy CR, Matsumoto RR
(2012) AAPS J 14: 43-51 - Synthesis and pharmacological evaluation of 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a cocaine antagonist, in rodents.
Kaushal N, Robson MJ, Vinnakota H, Narayanan S, Avery BA, McCurdy CR, Matsumoto RR
(2011) AAPS J 13: 336-46 - Benzodiazepines and the risk of falls in nursing home residents.
Ray WA, Thapa PB, Gideon P
(2000) J Am Geriatr Soc 48: 682-5 - Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane.
Liu L, Watanabe K, Fang Q, Williams KM, Guengerich FP, Pegg AE
(2007) Chem Res Toxicol 20: 155-63 - Mechanisms regulating the cell surface residence time of the alpha 2A-adrenergic receptor.
Wilson MH, Limbird LE
(2000) Biochemistry 39: 693-700 - Coupling efficiency of rhodopsin and transducin in bicelles.
Kaya AI, Thaker TM, Preininger AM, Iverson TM, Hamm HE
(2011) Biochemistry 50: 3193-203 - Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation.
Guengerich FP
(2005) Arch Biochem Biophys 433: 369-78 - Gadolinium-bearing red cells as blood pool MRI contrast agents.
Johnson KM, Tao JZ, Kennan RP, Gore JC
(1998) Magn Reson Med 40: 133-42 - Dysprosium-bearing red cells as potential transverse relaxation agents for MRI.
Johnson KM, Tao JZ, Kennan RP, Gore JC
(2001) Magn Reson Med 45: 920-3 - A short half-life GFP mouse model for analysis of suprachiasmatic nucleus organization.
LeSauter J, Yan L, Vishnubhotla B, Quintero JE, Kuhlman SJ, McMahon DG, Silver R
(2003) Brain Res 964: 279-87 - Pharmacokinetics of O6-benzylguanine (NSC637037) and its metabolite, 8-oxo-O6-benzylguanine.
Tserng KY, Ingalls ST, Boczko EM, Spiro TP, Li X, Majka S, Gerson SL, Willson JK, Hoppel CL
(2003) J Clin Pharmacol 43: 881-93 - Effect of modafinil on acute pain: a randomized double-blind crossover study.
Taneja I, Bruehl S, Robertson D
(2004) J Clin Pharmacol 44: 1425-7 - Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe.
Gentry PR, Kokubo M, Bridges TM, Cho HP, Smith E, Chase P, Hodder PS, Utley TJ, Rajapakse A, Byers F, Niswender CM, Morrison RD, Daniels JS, Wood MR, Conn PJ, Lindsley CW
(2014) ChemMedChem 9: 1677-82 - Position and length of fatty acids strongly affect receptor selectivity pattern of human pancreatic polypeptide analogues.
Mäde V, Bellmann-Sickert K, Kaiser A, Meiler J, Beck-Sickinger AG
(2014) ChemMedChem 9: 2463-74
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