Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels. Hallahan D, Geng L, Qu S, Scarfone C, Giorgio T, Donnelly E, Gao X, Clanton J (2003) Cancer Cell 3: 63-74 Consensus report of the national cancer institute clinical trials planning meeting on pancreas cancer treatment. Philip PA, Mooney M, Jaffe D, Eckhardt G, Moore M, Meropol N, Emens L, O'Reilly E, Korc M, Ellis L, Benedetti J, Rothenberg M, Willett C, Tempero M, Lowy A, Abbruzzese J, Simeone D, Hingorani S, Berlin J, Tepper J (2009) J Clin Oncol 27: 5660-9 Cardio-Oncology: How New Targeted Cancer Therapies and Precision Medicine Can Inform Cardiovascular Discovery. Bellinger AM, Arteaga CL, Force T, Humphreys BD, Demetri GD, Druker BJ, Moslehi JJ (2015) Circulation 132: 2248-58 Neurotoxin quantum dot conjugates detect endogenous targets expressed in live cancer cells. Orndorff RL, Rosenthal SJ (2009) Nano Lett 9: 2589-99 Direct imprinting of porous substrates: a rapid and low-cost approach for patterning porous nanomaterials. Ryckman JD, Liscidini M, Sipe JE, Weiss SM (2011) Nano Lett 11: 1857-62 Matrices for combined delivery of proteins and synthetic molecules. Gilmore KA, Lampley MW, Boyer C, Harth E (2016) Adv Drug Deliv Rev 98: 77-85 Targeting tumor cell motility to prevent metastasis. Palmer TD, Ashby WJ, Lewis JD, Zijlstra A (2011) Adv Drug Deliv Rev 63: 568-81 Endosomolytic Nano-Polyplex Platform Technology for Cytosolic Peptide Delivery To Inhibit Pathological Vasoconstriction. Evans BC, Hocking KM, Kilchrist KV, Wise ES, Brophy CM, Duvall CL (2015) ACS Nano 9: 5893-907 Gal8 Visualization of Endosome Disruption Predicts Carrier-Mediated Biologic Drug Intracellular Bioavailability. Kilchrist KV, Dimobi SC, Jackson MA, Evans BC, Werfel TA, Dailing EA, Bedingfield SK, Kelly IB, Duvall CL (2019) ACS Nano 13: 1136-1152 Therapeutic targeting of mitochondrial superoxide in hypertension. Dikalova AE, Bikineyeva AT, Budzyn K, Nazarewicz RR, McCann L, Lewis W, Harrison DG, Dikalov SI (2010) Circ Res 107: 106-16 An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles. Evans BC, Fletcher RB, Kilchrist KV, Dailing EA, Mukalel AJ, Colazo JM, Oliver M, Cheung-Flynn J, Brophy CM, Tierney JW, Isenberg JS, Hankenson KD, Ghimire K, Lander C, Gersbach CA, Duvall CL (2019) Nat Commun 10: 5012 Identifying mechanism-of-action targets for drugs and probes. Gregori-Puigjané E, Setola V, Hert J, Crews BA, Irwin JJ, Lounkine E, Marnett L, Roth BL, Shoichet BK (2012) Proc Natl Acad Sci U S A 109: 11178-83 Noninvasive intracellular delivery of functional peptides and proteins. Hawiger J (1999) Curr Opin Chem Biol 3: 89-94 Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia. Conn PJ, Lindsley CW, Jones CK (2009) Trends Pharmacol Sci 30: 25-31 Macrophage-Targeted Therapeutics for Metabolic Disease. Peterson KR, Cottam MA, Kennedy AJ, Hasty AH (2018) Trends Pharmacol Sci 39: 536-546 Promise of mGluR2/3 activators in psychiatry. Conn PJ, Jones CK (2009) Neuropsychopharmacology 34: 248-9 Pharmacological Treatments for Autism Spectrum Disorder: Will Emerging Approaches Yield New Treatments? Gogliotti RG, Conn PJ (2016) Neuropsychopharmacology 41: 376-7 Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model. Park SI, Zhang J, Phillips KA, Araujo JC, Najjar AM, Volgin AY, Gelovani JG, Kim SJ, Wang Z, Gallick GE (2008) Cancer Res 68: 3323-33 Targeted nanoparticles that deliver a sustained, specific release of Paclitaxel to irradiated tumors. Passarella RJ, Spratt DE, van der Ende AE, Phillips JG, Wu H, Sathiyakumar V, Zhou L, Hallahan DE, Harth E, Diaz R (2010) Cancer Res 70: 4550-9 Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides. Duca M, Guianvarc'h D, Oussedik K, Halby L, Garbesi A, Dauzonne D, Monneret C, Osheroff N, Giovannangeli C, Arimondo PB (2006) Nucleic Acids Res 34: 1900-11 Development of an integrated genomic classifier for a novel agent in colorectal cancer: approach to individualized therapy in early development. Pitts TM, Tan AC, Kulikowski GN, Tentler JJ, Brown AM, Flanigan SA, Leong S, Coldren CD, Hirsch FR, Varella-Garcia M, Korch C, Eckhardt SG (2010) Clin Cancer Res 16: 3193-204 Clinical trial design and end points for epidermal growth factor receptor-targeted therapies: implications for drug development and practice. Arteaga CL, Baselga J (2003) Clin Cancer Res 9: 1579-89 Targeting drug delivery to radiation-induced neoantigens in tumor microvasculature. Hallahan DE, Geng L, Cmelak AJ, Chakravarthy AB, Martin W, Scarfone C, Gonzalez A (2001) J Control Release 74: 183-91 Effects of local delivery of D-amino acids from biofilm-dispersive scaffolds on infection in contaminated rat segmental defects. Sanchez CJ, Prieto EM, Krueger CA, Zienkiewicz KJ, Romano DR, Ward CL, Akers KS, Guelcher SA, Wenke JC (2013) Biomaterials 34: 7533-43 MMPs as therapeutic targets--still a viable option? Fingleton B (2008) Semin Cell Dev Biol 19: 61-8 First-class delivery: getting growth factors to their destination. Davidson JM (2008) J Invest Dermatol 128: 1360-2 Combined MEK inhibition and BMP2 treatment promotes osteoblast differentiation and bone healing in Nf1Osx -/- mice. de la Croix Ndong J, Stevens DM, Vignaux G, Uppuganti S, Perrien DS, Yang X, Nyman JS, Harth E, Elefteriou F (2015) J Bone Miner Res 30: 55-63 Accelerating the development of novel molecular imaging probes: a role for high-throughput screening. Manning HC, Lander A, McKinley E, Mutic NJ (2008) J Nucl Med 49: 1401-4 Molecular determinants of melanoma malignancy: selecting targets for improved efficacy of chemotherapy. Yang J, Zaja-Milatovic S, Thu YM, Lee F, Smykla R, Richmond A (2009) Mol Cancer Ther 8: 636-47 Developing lipid nanoparticle-based siRNA therapeutics for hepatocellular carcinoma using an integrated approach. Li L, Wang R, Wilcox D, Sarthy A, Lin X, Huang X, Tian L, Dande P, Hubbard RD, Hansen TM, Wada C, Zhao X, Kohlbrenner WM, Fesik SW, Shen Y (2013) Mol Cancer Ther 12: 2308-18 Dual MMP7-proximity-activated and folate receptor-targeted nanoparticles for siRNA delivery. Li H, Miteva M, Kirkbride KC, Cheng MJ, Nelson CE, Simpson EM, Gupta MK, Duvall CL, Giorgio TD (2015) Biomacromolecules 16: 192-201 Identification of a therapeutic dose of continuously delivered erythropoietin in the eye using an inducible promoter system. Hines-Beard J, Desai S, Haag R, Esumi N, D'Surney L, Parker S, Richardson C, Rex TS (2013) Curr Gene Ther 13: 275-81 Lung adenocarcinoma: guiding EGFR-targeted therapy and beyond. Ladanyi M, Pao W (2008) Mod Pathol 21 Suppl 2: S16-22 Combination targeted therapy in advanced renal cell carcinoma. Sosman J, Puzanov I (2009) Cancer 115: 2368-75 Multilayer photodynamic therapy for highly effective and safe cancer treatment. Yang L, Zhang S, Ling X, Shao P, Jia N, Bai M (2017) Acta Biomater 54: 271-280 Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030. Lin L, Liu Y, Li H, Li PK, Fuchs J, Shibata H, Iwabuchi Y, Lin J (2011) Br J Cancer 105: 212-20 Endosomolytic and Tumor-Penetrating Mesoporous Silica Nanoparticles for siRNA/miRNA Combination Cancer Therapy. Wang Y, Xie Y, Kilchrist KV, Li J, Duvall CL, Oupický D (2020) ACS Appl Mater Interfaces 12: 4308-4322 Diclofenac enables unprecedented week-long microneedle-enhanced delivery of a skin impermeable medication in humans. Brogden NK, Banks SL, Crofford LJ, Stinchcomb AL (2013) Pharm Res 30: 1947-55 Dendritic molecular transporters provide control of delivery to intracellular compartments. Huang K, Voss B, Kumar D, Hamm HE, Harth E (2007) Bioconjug Chem 18: 403-9 Thermoresponsive Polymer Nanoparticles Co-deliver RSV F Trimers with a TLR-7/8 Adjuvant. Francica JR, Lynn GM, Laga R, Joyce MG, Ruckwardt TJ, Morabito KM, Chen M, Chaudhuri R, Zhang B, Sastry M, Druz A, Ko K, Choe M, Pechar M, Georgiev IS, Kueltzo LA, Seymour LW, Mascola JR, Kwong PD, Graham BS, Seder RA (2016) Bioconjug Chem 27: 2372-2385
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