Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory. Morozov A, Muzzio IA, Bourtchouladze R, Van-Strien N, Lapidus K, Yin D, Winder DG, Adams JP, Sweatt JD, Kandel ER (2003) Neuron 39: 309-25 E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function. Balzac F, Avolio M, Degani S, Kaverina I, Torti M, Silengo L, Small JV, Retta SF (2005) J Cell Sci 118: 4765-83 Rap1 activation is required for Fc gamma receptor-dependent phagocytosis. Chung J, Serezani CH, Huang SK, Stern JN, Keskin DB, Jagirdar R, Brock TG, Aronoff DM, Peters-Golden M (2008) J Immunol 181: 5501-9 JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function. Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA (2013) Mol Biol Cell 24: 2849-60 Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates. Holinstat M, Preininger AM, Milne SB, Hudson WJ, Brown HA, Hamm HE (2009) Mol Pharmacol 76: 301-13 Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathway. Holinstat M, Voss B, Bilodeau ML, Hamm HE (2007) Mol Pharmacol 71: 686-94 Oncogenic KRAS provides a uniquely powerful and variable oncogenic contribution among RAS family members in the colonic epithelium. Keller JW, Franklin JL, Graves-Deal R, Friedman DB, Whitwell CW, Coffey RJ (2007) J Cell Physiol 210: 740-9 Effects of prostaglandin E2 on the subcellular localization of Epac-1 and Rap1 proteins during Fcgamma-receptor-mediated phagocytosis in alveolar macrophages. Brock TG, Serezani CH, Carstens JK, Peters-Golden M, Aronoff DM (2008) Exp Cell Res 314: 255-63
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