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•  Albert Reynolds

•  Ethan Lee

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Publications

• Wnt-beta-catenin signaling initiates taste papilla development.
  Liu F, Thirumangalathu S, Gallant NM, Yang SH, Stoick-Cooper CL, Reddy ST, Andl T, Taketo MM, Dlugosz AA, Moon RT, Barlow LA, Millar SE
  (2007) Nat Genet 39: 106-12
• Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling.
  Yang SH, Andl T, Grachtchouk V, Wang A, Liu J, Syu LJ, Ferris J, Wang TS, Glick AB, Millar SE, Dlugosz AA
  (2008) Nat Genet 40: 1130-5
• Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells.
  Lippmann ES, Azarin SM, Kay JE, Nessler RA, Wilson HK, Al-Ahmad A, Palecek SP, Shusta EV
  (2012) Nat Biotechnol 30: 783-91
• p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho.
  Wildenberg GA, Dohn MR, Carnahan RH, Davis MA, Lobdell NA, Settleman J, Reynolds AB
  (2006) Cell 127: 1027-39
• p120-catenin mediates inflammatory responses in the skin.
  Perez-Moreno M, Davis MA, Wong E, Pasolli HA, Reynolds AB, Fuchs E
  (2006) Cell 124: 631-44
• A repeating amino acid motif shared by proteins with diverse cellular roles.
  Peifer M, Berg S, Reynolds AB
  (1994) Cell 76: 789-91
• Hairy math: insights into hair-follicle spacing and orientation.
  Stark J, Andl T, Millar SE
  (2007) Cell 128: 17-20
• Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene.
  Stairs DB, Bayne LJ, Rhoades B, Vega ME, Waldron TJ, Kalabis J, Klein-Szanto A, Lee JS, Katz JP, Diehl JA, Reynolds AB, Vonderheide RH, Rustgi AK
  (2011) Cancer Cell 19: 470-83
• lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling.
  Lu Y, Zhao X, Liu Q, Li C, Graves-Deal R, Cao Z, Singh B, Franklin JL, Wang J, Hu H, Wei T, Yang M, Yeatman TJ, Lee E, Saito-Diaz K, Hinger S, Patton JG, Chung CH, Emmrich S, Klusmann JH, Fan D, Coffey RJ
  (2017) Nat Med 23: 1331-1341
• Inhibition of RhoA by p120 catenin.
  Anastasiadis PZ, Moon SY, Thoreson MA, Mariner DJ, Crawford HC, Zheng Y, Reynolds AB
  (2000) Nat Cell Biol 2: 637-44
• Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts.
  Salic A, Lee E, Mayer L, Kirschner MW
  (2000) Mol Cell 5: 523-32
• Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.
  Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM, Lee E
  (2010) Nat Chem Biol 6: 829-36
• Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland.
  Davis MA, Reynolds AB
  (2006) Dev Cell 10: 21-31
• APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway.
  Saito-Diaz K, Benchabane H, Tiwari A, Tian A, Li B, Thompson JJ, Hyde AS, Sawyer LM, Jodoin JN, Santos E, Lee LA, Coffey RJ, Beauchamp RD, Williams CS, Kenworthy AK, Robbins DJ, Ahmed Y, Lee E
  (2018) Dev Cell 44: 566-581.e8
• Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction.
  Zhang Y, Tomann P, Andl T, Gallant NM, Huelsken J, Jerchow B, Birchmeier W, Paus R, Piccolo S, Mikkola ML, Morrisey EE, Overbeek PA, Scheidereit C, Millar SE, Schmidt-Ullrich R
  (2009) Dev Cell 17: 49-61
• p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate.
  Nyeng P, Heilmann S, Löf-Öhlin ZM, Pettersson NF, Hermann FM, Reynolds AB, Semb H
  (2019) Dev Cell 49: 31-47.e9
• WNT signals are required for the initiation of hair follicle development.
  Andl T, Reddy ST, Gaddapara T, Millar SE
  (2002) Dev Cell 2: 643-53
• Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin.
  Freeman TJ, Smith JJ, Chen X, Washington MK, Roland JT, Means AL, Eschrich SA, Yeatman TJ, Deane NG, Beauchamp RD
  (2012) Gastroenterology 142: 562-571.e2
• The role of PPARgamma in colon cancer: is it as simple as APC?
  Peek RM
  (2003) Gastroenterology 125: 619-21
• β-Catenin and p120 mediate PPARδ-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia.
  Nagy TA, Wroblewski LE, Wang D, Piazuelo MB, Delgado A, Romero-Gallo J, Noto J, Israel DA, Ogden SR, Correa P, Cover TL, Peek RM
  (2011) Gastroenterology 141: 553-64
• Beta-catenin in the liver: an integrator of proliferation and metabolism?
  Scheving LA, Russell WE
  (2006) Gastroenterology 131: 1641-3
• Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia.
  Nam KT, Lee HJ, Mok H, Romero-Gallo J, Crowe JE, Peek RM, Goldenring JR
  (2009) Gastroenterology 136: 1288-96
• TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.
  Trobridge P, Knoblaugh S, Washington MK, Munoz NM, Tsuchiya KD, Rojas A, Song X, Ulrich CM, Sasazuki T, Shirasawa S, Grady WM
  (2009) Gastroenterology 136: 1680-8.e7
• SPDEF functions as a colorectal tumor suppressor by inhibiting β-catenin activity.
  Noah TK, Lo YH, Price A, Chen G, King E, Washington MK, Aronow BJ, Shroyer NF
  (2013) Gastroenterology 144: 1012-1023.e6
• Making Cancer Quiescent: SPDEF De-Cycles Beta-Catenin.
  Fingleton B
  (2017) Gastroenterology 153: 10-12
• p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia.
  Short SP, Kondo J, Smalley-Freed WG, Takeda H, Dohn MR, Powell AE, Carnahan RH, Washington MK, Tripathi M, Payne DM, Jenkins NA, Copeland NG, Coffey RJ, Reynolds AB
  (2017) J Clin Invest 127: 4462-4476
• p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice.
  Smalley-Freed WG, Efimov A, Burnett PE, Short SP, Davis MA, Gumucio DL, Washington MK, Coffey RJ, Reynolds AB
  (2010) J Clin Invest 120: 1824-35
• Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer.
  Dhawan P, Singh AB, Deane NG, No Y, Shiou SR, Schmidt C, Neff J, Washington MK, Beauchamp RD
  (2005) J Clin Invest 115: 1765-76
• Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury.
  Volckaert T, Dill E, Campbell A, Tiozzo C, Majka S, Bellusci S, De Langhe SP
  (2011) J Clin Invest 121: 4409-19
• Epithelial stem cell mutations that promote squamous cell carcinoma metastasis.
  White RA, Neiman JM, Reddi A, Han G, Birlea S, Mitra D, Dionne L, Fernandez P, Murao K, Bian L, Keysar SB, Goldstein NB, Song N, Bornstein S, Han Z, Lu X, Wisell J, Li F, Song J, Lu SL, Jimeno A, Roop DR, Wang XJ
  (2013) J Clin Invest 123: 4390-404
• CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies.
  McGeachie MJ, Wu AC, Tse SM, Clemmer GL, Sordillo J, Himes BE, Lasky-Su J, Chase RP, Martinez FD, Weeke P, Shaffer CM, Xu H, Denny JC, Roden DM, Panettieri RA, Raby BA, Weiss ST, Tantisira KG
  (2015) J Allergy Clin Immunol 136: 1503-1510
• p120-Catenin is required for mouse vascular development.
  Oas RG, Xiao K, Summers S, Wittich KB, Chiasson CM, Martin WD, Grossniklaus HE, Vincent PA, Reynolds AB, Kowalczyk AP
  (2010) Circ Res 106: 941-51
• Protecting your tail: regulation of cadherin degradation by p120-catenin.
  Kowalczyk AP, Reynolds AB
  (2004) Curr Opin Cell Biol 16: 522-7
• Regulation of Rho GTPases by p120-catenin.
  Anastasiadis PZ, Reynolds AB
  (2001) Curr Opin Cell Biol 13: 604-10
• β-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin.
  Tanjore H, Degryse AL, Crossno PF, Xu XC, McConaha ME, Jones BR, Polosukhin VV, Bryant AJ, Cheng DS, Newcomb DC, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE
  (2013) Am J Respir Crit Care Med 187: 630-9
• Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon.
  Lee E, Salic A, Kirschner MW
  (2001) J Cell Biol 154: 983-93
• Integrated biochemical and mechanical signals regulate multifaceted human embryonic stem cell functions.
  Li D, Zhou J, Wang L, Shin ME, Su P, Lei X, Kuang H, Guo W, Yang H, Cheng L, Tanaka TS, Leckband DE, Reynolds AB, Duan E, Wang F
  (2010) J Cell Biol 191: 631-44
• A core function for p120-catenin in cadherin turnover.
  Davis MA, Ireton RC, Reynolds AB
  (2003) J Cell Biol 163: 525-34