Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage. Morrow JD, Frei B, Longmire AW, Gaziano JM, Lynch SM, Shyr Y, Strauss WE, Oates JA, Roberts LJ (1995) N Engl J Med 332: 1198-203 Free radical lipid peroxidation: mechanisms and analysis. Yin H, Xu L, Porter NA (2011) Chem Rev 111: 5944-72 Isoprostane generation and function. Milne GL, Yin H, Hardy KD, Davies SS, Roberts LJ (2011) Chem Rev 111: 5973-96 Increased lipid peroxidation in patients with rhabdomyolysis. Holt S, Reeder B, Wilson M, Harvey S, Morrow JD, Roberts LJ, Moore K (1999) Lancet 353: 1241 Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver. Chaudhary AK, Nokubo M, Reddy GR, Yeola SN, Morrow JD, Blair IA, Marnett LJ (1994) Science 265: 1580-2 Free radical oxidation of polyunsaturated lipids: New mechanistic insights and the development of peroxyl radical clocks. Pratt DA, Tallman KA, Porter NA (2011) Acc Chem Res 44: 458-67 Interstrand DNA cross-links induced by alpha,beta-unsaturated aldehydes derived from lipid peroxidation and environmental sources. Stone MP, Cho YJ, Huang H, Kim HY, Kozekov ID, Kozekova A, Wang H, Minko IG, Lloyd RS, Harris TM, Rizzo CJ (2008) Acc Chem Res 41: 793-804 Fluorescent probes of the apoptolidins and their utility in cellular localization studies. DeGuire SM, Earl DC, Du Y, Crews BA, Jacobs AT, Ustione A, Daniel C, Chong KM, Marnett LJ, Piston DW, Bachmann BO, Sulikowski GA (2015) Angew Chem Int Ed Engl 54: 961-4 Formation of non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro. Lynch SM, Morrow JD, Roberts LJ, Frei B (1994) J Clin Invest 93: 998-1004 Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation. Morrow JD, Awad JA, Kato T, Takahashi K, Badr KF, Roberts LJ, Burk RF (1992) J Clin Invest 90: 2502-7 On the mechanism of biosynthesis of 5- and 15-series leukotrienes. Brash AR, Maas RL, Oates JA (1984) J Allergy Clin Immunol 74: 316-23 Pathogenesis of diquat-induced liver necrosis in selenium-deficient rats: assessment of the roles of lipid peroxidation and selenoprotein P. Burk RF, Hill KE, Awad JA, Morrow JD, Kato T, Cockell KA, Lyons PR (1995) Hepatology 21: 561-9 Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels. Fukuda K, Davies SS, Nakajima T, Ong BH, Kupershmidt S, Fessel J, Amarnath V, Anderson ME, Boyden PA, Viswanathan PC, Roberts LJ, Balser JR (2005) Circ Res 97: 1262-9 Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E. Yang H, Roberts LJ, Shi MJ, Zhou LC, Ballard BR, Richardson A, Guo ZM (2004) Circ Res 95: 1075-81 Formation of F2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitrite. Moore KP, Darley-Usmar V, Morrow J, Roberts LJ (1995) Circ Res 77: 335-41 The isoprostanes: their role as an index of oxidant stress status in human pulmonary disease. Morrow JD, Roberts LJ (2002) Am J Respir Crit Care Med 166: S25-30 Formation of isoprostane bicyclic endoperoxides from the autoxidation of cholesteryl arachidonate. Yin H, Havrilla CM, Morrow JD, Porter NA (2002) J Am Chem Soc 124: 7745-54 In vivo and in vitro lipid peroxidation of arachidonate esters: the effect of fish oil omega-3 lipids on product distribution. Davis TA, Gao L, Yin H, Morrow JD, Porter NA (2006) J Am Chem Soc 128: 14897-904 Tetrahydro-1,8-naphthyridinol analogues of alpha-tocopherol as antioxidants in lipid membranes and low-density lipoproteins. Nam TG, Rector CL, Kim HY, Sonnen AF, Meyer R, Nau WM, Atkinson J, Rintoul J, Pratt DA, Porter NA (2007) J Am Chem Soc 129: 10211-9 Site-specific synthesis and reactivity of oligonucleotides containing stereochemically defined 1,N2-deoxyguanosine adducts of the lipid peroxidation product trans-4-hydroxynonenal. Wang H, Kozekov ID, Harris TM, Rizzo CJ (2003) J Am Chem Soc 125: 5687-700 Kinetic products of linoleate peroxidation: rapid beta-fragmentation of nonconjugated peroxyls. Tallman KA, Pratt DA, Porter NA (2001) J Am Chem Soc 123: 11827-8 Tyrosine-lipid peroxide adducts from radical termination: para coupling and intramolecular Diels-Alder cyclization. Shchepin R, Möller MN, Kim HY, Hatch DM, Bartesaghi S, Kalyanaraman B, Radi R, Porter NA (2010) J Am Chem Soc 132: 17490-500 Minimizing tocopherol-mediated radical phase transfer in low-density lipoprotein oxidation with an amphiphilic unsymmetrical azo initiator. Culbertson SM, Vinqvist MR, Barclay LR, Porter NA (2001) J Am Chem Soc 123: 8951-60 The isoprostanes: unique bioactive products of lipid peroxidation. Morrow JD, Roberts LJ (1997) Prog Lipid Res 36: 1-21 A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation. Coffa G, Brash AR (2004) Proc Natl Acad Sci U S A 101: 15579-84 Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct. Mao H, Schnetz-Boutaud NC, Weisenseel JP, Marnett LJ, Stone MP (1999) Proc Natl Acad Sci U S A 96: 6615-20 Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases. Boutaud O, Aronoff DM, Richardson JH, Marnett LJ, Oates JA (2002) Proc Natl Acad Sci U S A 99: 7130-5 Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure. Boutaud O, Moore KP, Reeder BJ, Harry D, Howie AJ, Wang S, Carney CK, Masterson TS, Amin T, Wright DW, Wilson MT, Oates JA, Roberts LJ (2010) Proc Natl Acad Sci U S A 107: 2699-704 Molecular cloning of an allene oxide synthase: a cytochrome P450 specialized for the metabolism of fatty acid hydroperoxides. Song WC, Funk CD, Brash AR (1993) Proc Natl Acad Sci U S A 90: 8519-23 Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids. Morrow JD, Awad JA, Boss HJ, Blair IA, Roberts LJ (1992) Proc Natl Acad Sci U S A 89: 10721-5 A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Morrow JD, Hill KE, Burk RF, Nammour TM, Badr KF, Roberts LJ (1990) Proc Natl Acad Sci U S A 87: 9383-7 Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension. Fessel JP, Porter NA, Moore KP, Sheller JR, Roberts LJ (2002) Proc Natl Acad Sci U S A 99: 16713-8 The structure of coral allene oxide synthase reveals a catalase adapted for metabolism of a fatty acid hydroperoxide. Oldham ML, Brash AR, Newcomer ME (2005) Proc Natl Acad Sci U S A 102: 297-302 Evidence for a lipoxygenase mechanism in the biosynthesis of epoxide and dihydroxy leukotrienes from 15(S)-hydroperoxyicosatetraenoic acid by human platelets and porcine leukocytes. Maas RL, Brash AR (1983) Proc Natl Acad Sci U S A 80: 2884-8 In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG. Otteneder MB, Knutson CG, Daniels JS, Hashim M, Crews BC, Remmel RP, Wang H, Rizzo C, Marnett LJ (2006) Proc Natl Acad Sci U S A 103: 6665-9 Failure of antioxidant therapy to attenuate interstitial disease in rats with reversible nephrotic syndrome. Drukker A, Eddy AA (1998) J Am Soc Nephrol 9: 243-51 Oxidative stress and inflammation are associated with adiposity in moderate to severe CKD. Ramos LF, Shintani A, Ikizler TA, Himmelfarb J (2008) J Am Soc Nephrol 19: 593-9 Tamoxifen induces oxidative stress and mitochondrial apoptosis via stimulating mitochondrial nitric oxide synthase. Nazarewicz RR, Zenebe WJ, Parihar A, Larson SK, Alidema E, Choi J, Ghafourifar P (2007) Cancer Res 67: 1282-90 Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA. Wauchope OR, Mitchener MM, Beavers WN, Galligan JJ, Camarillo JM, Sanders WD, Kingsley PJ, Shim HN, Blackwell T, Luong T, deCaestecker M, Fessel JP, Marnett LJ (2018) Nucleic Acids Res 46: 3458-3467
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