Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin. Winder DG, Mansuy IM, Osman M, Moallem TM, Kandel ER (1998) Cell 92: 25-37 Cytokinesis monitoring during development; rapid pole-to-pole shuttling of a signaling protein by localized kinase and phosphatase in Caulobacter. Matroule JY, Lam H, Burnette DT, Jacobs-Wagner C (2004) Cell 118: 579-90 Roles of serine/threonine phosphatases in hippocampal synaptic plasticity. Winder DG, Sweatt JD (2001) Nat Rev Neurosci 2: 461-74 Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase. Gould KL, Moreno S, Tonks NK, Nurse P (1990) Science 250: 1573-6 Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. Liu J, Ghanim M, Xue L, Brown CD, Iossifov I, Angeletti C, Hua S, Nègre N, Ludwig M, Stricker T, Al-Ahmadie HA, Tretiakova M, Camp RL, Perera-Alberto M, Rimm DL, Xu T, Rzhetsky A, White KP (2009) Science 323: 1218-22 A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A. Westphal RS, Anderson KA, Means AR, Wadzinski BE (1998) Science 280: 1258-61 Phospho-regulation of the Cdc14/Clp1 phosphatase delays late mitotic events in S. pombe. Wolfe BA, McDonald WH, Yates JR, Gould KL (2006) Dev Cell 11: 423-30 Lipid research picks up speed on the slopes of Taos. Field SJ, Lamia KA, Rameh LE, Cantley LC (2002) Dev Cell 2: 407-10 Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. Zhang X, Ozawa Y, Lee H, Wen YD, Tan TH, Wadzinski BE, Seto E (2005) Genes Dev 19: 827-39 Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent. Palmer ND, Musani SK, Yerges-Armstrong LM, Feitosa MF, Bielak LF, Hernaez R, Kahali B, Carr JJ, Harris TB, Jhun MA, Kardia SL, Langefeld CD, Mosley TH, Norris JM, Smith AV, Taylor HA, Wagenknecht LE, Liu J, Borecki IB, Peyser PA, Speliotes EK (2013) Hepatology 58: 966-75 B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression. Irish JM, Myklebust JH, Alizadeh AA, Houot R, Sharman JP, Czerwinski DK, Nolan GP, Levy R (2010) Proc Natl Acad Sci U S A 107: 12747-54 Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver. Kabashima T, Kawaguchi T, Wadzinski BE, Uyeda K (2003) Proc Natl Acad Sci U S A 100: 5107-12 Fission yeast Clp1p phosphatase regulates G2/M transition and coordination of cytokinesis with cell cycle progression. Trautmann S, Wolfe BA, Jorgensen P, Tyers M, Gould KL, McCollum D (2001) Curr Biol 11: 931-40 Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation. Chiang CW, Harris G, Ellig C, Masters SC, Subramanian R, Shenolikar S, Wadzinski BE, Yang E (2001) Blood 97: 1289-97 Cloning and characterization of a novel subunit of protein serine/threonine phosphatase 4 from mesangial cells. Wada T, Miyata T, Inagi R, Nangaku M, Wagatsuma M, Suzuki D, Wadzinski BE, Okubo K, Kurokawa K (2001) J Am Soc Nephrol 12: 2601-2608 Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers. Haruki N, Kawaguchi KS, Eichenberger S, Massion PP, Olson S, Gonzalez A, Carbone DP, Dang TP (2005) Cancer Res 65: 3555-61 Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway. McConnell JL, Gomez RJ, McCorvey LR, Law BK, Wadzinski BE (2007) Oncogene 26: 6021-30 PPM1A is a RelA phosphatase with tumor suppressor-like activity. Lu X, An H, Jin R, Zou M, Guo Y, Su PF, Liu D, Shyr Y, Yarbrough WG (2014) Oncogene 33: 2918-27 Novel blockade of protein kinase A-mediated phosphorylation of AMPA receptors. Vanhoose AM, Clements JM, Winder DG (2006) J Neurosci 26: 1138-45 Protein phosphatases and calcium/calmodulin-dependent protein kinase II-dependent synaptic plasticity. Colbran RJ (2004) J Neurosci 24: 8404-9 Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A. Bauman AL, Apparsundaram S, Ramamoorthy S, Wadzinski BE, Vaughan RA, Blakely RD (2000) J Neurosci 20: 7571-8 Rapid commitment to negative selection of a thymocyte line independent of CD4 co-engagement. Kovalik JP, Ansari B, Boothby M (1996) J Immunol 157: 5290-9 Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. Chiang CW, Kanies C, Kim KW, Fang WB, Parkhurst C, Xie M, Henry T, Yang E (2003) Mol Cell Biol 23: 6350-62 Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation. Wadzinski BE, Wheat WH, Jaspers S, Peruski LF, Lickteig RL, Johnson GL, Klemm DJ (1993) Mol Cell Biol 13: 2822-34 The mechanism of action of cantharidin in smooth muscle. Knapp J, Bokník P, Huke S, Lüss H, Müller FU, Müller T, Nacke P, Schmitz W, Vahlensieck U, Neumann J (1998) Br J Pharmacol 123: 911-9 Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit. Bryant JC, Westphal RS, Wadzinski BE (1999) Biochem J 339 ( Pt 2): 241-6 Carboxymethylation of nuclear protein serine/threonine phosphatase X. Kloeker S, Bryant JC, Strack S, Colbran RJ, Wadzinski BE (1997) Biochem J 327 ( Pt 2): 481-6 NH2-terminal modification of the phosphatase 2A catalytic subunit allows functional expression in mammalian cells. Wadzinski BE, Eisfelder BJ, Peruski LF, Mumby MC, Johnson GL (1992) J Biol Chem 267: 16883-8 Purification and identification of a novel subunit of protein serine/threonine phosphatase 4. Kloeker S, Wadzinski BE (1999) J Biol Chem 274: 5339-47 Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A. Westphal RS, Coffee RL, Marotta A, Pelech SL, Wadzinski BE (1999) J Biol Chem 274: 687-92 Phosphorylation and regulation of antidepressant-sensitive serotonin transporters. Ramamoorthy S, Giovanetti E, Qian Y, Blakely RD (1998) J Biol Chem 273: 2458-66 The RIPE3b1 activator of the insulin gene is composed of a protein(s) of approximately 43 kDa, whose DNA binding activity is inhibited by protein phosphatase treatment. Zhao L, Cissell MA, Henderson E, Colbran R, Stein R (2000) J Biol Chem 275: 10532-7 Phosphorylation-independent association of CXCR2 with the protein phosphatase 2A core enzyme. Fan GH, Yang W, Sai J, Richmond A (2001) J Biol Chem 276: 16960-8 A protein phosphatase-1gamma1 isoform selectivity determinant in dendritic spine-associated neurabin. Carmody LC, Bauman PA, Bass MA, Mavila N, DePaoli-Roach AA, Colbran RJ (2004) J Biol Chem 279: 21714-23 O-GlcNAc transferase is in a functional complex with protein phosphatase 1 catalytic subunits. Wells L, Kreppel LK, Comer FI, Wadzinski BE, Hart GW (2004) J Biol Chem 279: 38466-70 p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process. Zhu CB, Carneiro AM, Dostmann WR, Hewlett WA, Blakely RD (2005) J Biol Chem 280: 15649-58 Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes. Adams DG, Coffee RL, Zhang H, Pelech S, Strack S, Wadzinski BE (2005) J Biol Chem 280: 42644-54 Protein phosphatases 2A and 1 interact with occludin and negatively regulate the assembly of tight junctions in the CACO-2 cell monolayer. Seth A, Sheth P, Elias BC, Rao R (2007) J Biol Chem 282: 11487-98 Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation. Fritz A, Brayer KJ, McCormick N, Adams DG, Wadzinski BE, Vaillancourt RR (2006) J Biol Chem 281: 6236-45 Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt. Van Kanegan MJ, Adams DG, Wadzinski BE, Strack S (2005) J Biol Chem 280: 36029-36
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