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•  Aliya Gifford
•  Alyssa Hasty
•  Brian Welch

•  J Greg Terry
•  John Stafford
•  Myriam Diaz Martinez

•  Subhadra Gunawardana

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Communities

• Fat-Water MRI Lab

Publications

• The natriuretic peptides and fat metabolism.
  Wang TJ
  (2012) N Engl J Med 367: 377-8
• Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.
  Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS
  (2007) Nature 447: 959-65
• Obesity-associated variants within FTO form long-range functional connections with IRX3.
  Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MA
  (2014) Nature 507: 371-5
• Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.
  Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM
  (2014) Cell 156: 304-16
• The protein kinase IKKepsilon regulates energy balance in obese mice.
  Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR
  (2009) Cell 138: 961-75
• Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity.
  Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y
  (2006) Science 312: 1656-9
• Association between duration of overall and abdominal obesity beginning in young adulthood and coronary artery calcification in middle age.
  Reis JP, Loria CM, Lewis CE, Powell-Wiley TM, Wei GS, Carr JJ, Terry JG, Liu K
  (2013) JAMA 310: 280-8
• Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.
  Scarlett JM, Rojas JM, Matsen ME, Kaiyala KJ, Stefanovski D, Bergman RN, Nguyen HT, Dorfman MD, Lantier L, Wasserman DH, Mirzadeh Z, Unterman TG, Morton GJ, Schwartz MW
  (2016) Nat Med 22: 800-6
• SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.
  Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC
  (2013) Mol Cell 50: 686-98
• Anatomy and regulation of the central melanocortin system.
  Cone RD
  (2005) Nat Neurosci 8: 571-8
• Adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction in Costa Rica.
  Baylin A, Kabagambe EK, Ascherio A, Spiegelman D, Campos H
  (2003) Circulation 107: 1586-91
• Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice.
  Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS
  (2004) Circulation 110: 1492-8
• Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis.
  Albaugh VL, Judson JG, She P, Lang CH, Maresca KP, Joyal JL, Lynch CJ
  (2011) Mol Psychiatry 16: 569-81
• VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications.
  Robciuc MR, Kivelä R, Williams IM, de Boer JF, van Dijk TH, Elamaa H, Tigistu-Sahle F, Molotkov D, Leppänen VM, Käkelä R, Eklund L, Wasserman DH, Groen AK, Alitalo K
  (2016) Cell Metab 23: 712-24
• β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.
  Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, Cowan CA, Spiegelman BM, Gerszten RE
  (2014) Cell Metab 19: 96-108
• Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial.
  Nass R, Pezzoli SS, Oliveri MC, Patrie JT, Harrell FE, Clasey JL, Heymsfield SB, Bach MA, Vance ML, Thorner MO
  (2008) Ann Intern Med 149: 601-11
• Comparison of the direct and indirect effects of epinephrine on hepatic glucose production.
  Chu CA, Sindelar DK, Neal DW, Allen EJ, Donahue EP, Cherrington AD
  (1997) J Clin Invest 99: 1044-56
• Obesity and the beta cell: lessons from leptin.
  Niswender KD, Magnuson MA
  (2007) J Clin Invest 117: 2753-6
• Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.
  Li JZ, Huang Y, Karaman R, Ivanova PT, Brown HA, Roddy T, Castro-Perez J, Cohen JC, Hobbs HH
  (2012) J Clin Invest 122: 4130-44
• IRF3 promotes adipose inflammation and insulin resistance and represses browning.
  Kumari M, Wang X, Lantier L, Lyubetskaya A, Eguchi J, Kang S, Tenen D, Roh HC, Kong X, Kazak L, Ahmad R, Rosen ED
  (2016) J Clin Invest 126: 2839-54
• A decade of progress in adipose tissue macrophage biology.
  Hill AA, Reid Bolus W, Hasty AH
  (2014) Immunol Rev 262: 134-52
• Genetic risk factors for type 2 diabetes: a trans-regulatory genetic architecture?
  Elbein SC, Gamazon ER, Das SK, Rasouli N, Kern PA, Cox NJ
  (2012) Am J Hum Genet 91: 466-77
• Cross-tissue and tissue-specific eQTLs: partitioning the heritability of a complex trait.
  Torres JM, Gamazon ER, Parra EJ, Below JE, Valladares-Salgado A, Wacher N, Cruz M, Hanis CL, Cox NJ
  (2014) Am J Hum Genet 95: 521-34
• A functional synonymous coding variant in the IL1RN gene is associated with survival in septic shock.
  Meyer NJ, Ferguson JF, Feng R, Wang F, Patel PN, Li M, Xue C, Qu L, Liu Y, Boyd JH, Russell JA, Christie JD, Walley KR, Reilly MP
  (2014) Am J Respir Crit Care Med 190: 656-64
• Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function.
  Muraoka RS, Lenferink AE, Simpson J, Brantley DM, Roebuck LR, Yakes FM, Arteaga CL
  (2001) J Cell Biol 153: 917-32
• Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling.
  Boucher J, Mori MA, Lee KY, Smyth G, Liew CW, Macotela Y, Rourk M, Bluher M, Russell SJ, Kahn CR
  (2012) Nat Commun 3: 902
• HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning.
  Ferrari A, Longo R, Fiorino E, Silva R, Mitro N, Cermenati G, Gilardi F, Desvergne B, Andolfo A, Magagnotti C, Caruso D, Fabiani E, Hiebert SW, Crestani M
  (2017) Nat Commun 8: 93
• Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice.
  Wu L, Parekh VV, Gabriel CL, Bracy DP, Marks-Shulman PA, Tamboli RA, Kim S, Mendez-Fernandez YV, Besra GS, Lomenick JP, Williams B, Wasserman DH, Van Kaer L
  (2012) Proc Natl Acad Sci U S A 109: E1143-52
• Pyruvate induces torpor in obese mice.
  Soto M, Orliaguet L, Reyzer ML, Manier ML, Caprioli RM, Kahn CR
  (2018) Proc Natl Acad Sci U S A 115: 810-815
• De novo generation of white adipocytes from the myeloid lineage via mesenchymal intermediates is age, adipose depot, and gender specific.
  Majka SM, Fox KE, Psilas JC, Helm KM, Childs CR, Acosta AS, Janssen RC, Friedman JE, Woessner BT, Shade TR, Varella-Garcia M, Klemm DJ
  (2010) Proc Natl Acad Sci U S A 107: 14781-6
• Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance.
  Wu L, Parekh VV, Hsiao J, Kitamura D, Van Kaer L
  (2014) Proc Natl Acad Sci U S A 111: E4638-47
• Increase in membrane uptake of long-chain fatty acids early during preadipocyte differentiation.
  Abumrad NA, Forest CC, Regen DM, Sanders S
  (1991) Proc Natl Acad Sci U S A 88: 6008-12
• Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes.
  Imai T, Jiang M, Chambon P, Metzger D
  (2001) Proc Natl Acad Sci U S A 98: 224-8
• Melanocortin-3 receptor regulates the normal fasting response.
  Renquist BJ, Murphy JG, Larson EA, Olsen D, Klein RF, Ellacott KL, Cone RD
  (2012) Proc Natl Acad Sci U S A 109: E1489-98
• Induction of aP2 gene expression by nonmetabolized long-chain fatty acids.
  Grimaldi PA, Knobel SM, Whitesell RR, Abumrad NA
  (1992) Proc Natl Acad Sci U S A 89: 10930-4