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•  Aliya Gifford
•  Alyssa Hasty
•  Brian Welch

•  J Greg Terry
•  John Stafford
•  Myriam Diaz Martinez

•  Subhadra Gunawardana

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Communities

• Fat-Water MRI Lab

Publications

• The natriuretic peptides and fat metabolism.
  Wang TJ
  (2012) N Engl J Med 367: 377-8
• Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.
  Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS
  (2007) Nature 447: 959-65
• Obesity-associated variants within FTO form long-range functional connections with IRX3.
  Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MA
  (2014) Nature 507: 371-5
• The protein kinase IKKepsilon regulates energy balance in obese mice.
  Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR
  (2009) Cell 138: 961-75
• Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.
  Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM
  (2014) Cell 156: 304-16
• Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity.
  Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y
  (2006) Science 312: 1656-9
• Association between duration of overall and abdominal obesity beginning in young adulthood and coronary artery calcification in middle age.
  Reis JP, Loria CM, Lewis CE, Powell-Wiley TM, Wei GS, Carr JJ, Terry JG, Liu K
  (2013) JAMA 310: 280-8
• Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.
  Scarlett JM, Rojas JM, Matsen ME, Kaiyala KJ, Stefanovski D, Bergman RN, Nguyen HT, Dorfman MD, Lantier L, Wasserman DH, Mirzadeh Z, Unterman TG, Morton GJ, Schwartz MW
  (2016) Nat Med 22: 800-6
• Beta-adrenergic receptors and regulation of energy expenditure: a family affair.
  Robidoux J, Martin TL, Collins S
  (2004) Annu Rev Pharmacol Toxicol 44: 297-323
• SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.
  Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC
  (2013) Mol Cell 50: 686-98
• Anatomy and regulation of the central melanocortin system.
  Cone RD
  (2005) Nat Neurosci 8: 571-8
• Adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction in Costa Rica.
  Baylin A, Kabagambe EK, Ascherio A, Spiegelman D, Campos H
  (2003) Circulation 107: 1586-91
• Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice.
  Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS
  (2004) Circulation 110: 1492-8
• Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis.
  Albaugh VL, Judson JG, She P, Lang CH, Maresca KP, Joyal JL, Lynch CJ
  (2011) Mol Psychiatry 16: 569-81
• β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.
  Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, Cowan CA, Spiegelman BM, Gerszten RE
  (2014) Cell Metab 19: 96-108
• VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications.
  Robciuc MR, Kivelä R, Williams IM, de Boer JF, van Dijk TH, Elamaa H, Tigistu-Sahle F, Molotkov D, Leppänen VM, Käkelä R, Eklund L, Wasserman DH, Groen AK, Alitalo K
  (2016) Cell Metab 23: 712-24
• Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial.
  Nass R, Pezzoli SS, Oliveri MC, Patrie JT, Harrell FE, Clasey JL, Heymsfield SB, Bach MA, Vance ML, Thorner MO
  (2008) Ann Intern Med 149: 601-11
• Comparison of the direct and indirect effects of epinephrine on hepatic glucose production.
  Chu CA, Sindelar DK, Neal DW, Allen EJ, Donahue EP, Cherrington AD
  (1997) J Clin Invest 99: 1044-56
• Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes.
  Bordicchia M, Liu D, Amri EZ, Ailhaud G, Dessì-Fulgheri P, Zhang C, Takahashi N, Sarzani R, Collins S
  (2012) J Clin Invest 122: 1022-36
• Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.
  Li JZ, Huang Y, Karaman R, Ivanova PT, Brown HA, Roddy T, Castro-Perez J, Cohen JC, Hobbs HH
  (2012) J Clin Invest 122: 4130-44
• Obesity and the beta cell: lessons from leptin.
  Niswender KD, Magnuson MA
  (2007) J Clin Invest 117: 2753-6
• Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning.
  Liu D, Bordicchia M, Zhang C, Fang H, Wei W, Li JL, Guilherme A, Guntur K, Czech MP, Collins S
  (2016) J Clin Invest 126: 1704-16
• IRF3 promotes adipose inflammation and insulin resistance and represses browning.
  Kumari M, Wang X, Lantier L, Lyubetskaya A, Eguchi J, Kang S, Tenen D, Roh HC, Kong X, Kazak L, Ahmad R, Rosen ED
  (2016) J Clin Invest 126: 2839-54
• p62 links β-adrenergic input to mitochondrial function and thermogenesis.
  Müller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner KM, Hofmann S, Holland J, Küchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever SC, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J, Tschöp MH
  (2013) J Clin Invest 123: 469-78
• A decade of progress in adipose tissue macrophage biology.
  Hill AA, Reid Bolus W, Hasty AH
  (2014) Immunol Rev 262: 134-52
• Genetic risk factors for type 2 diabetes: a trans-regulatory genetic architecture?
  Elbein SC, Gamazon ER, Das SK, Rasouli N, Kern PA, Cox NJ
  (2012) Am J Hum Genet 91: 466-77
• Cross-tissue and tissue-specific eQTLs: partitioning the heritability of a complex trait.
  Torres JM, Gamazon ER, Parra EJ, Below JE, Valladares-Salgado A, Wacher N, Cruz M, Hanis CL, Cox NJ
  (2014) Am J Hum Genet 95: 521-34
• A functional synonymous coding variant in the IL1RN gene is associated with survival in septic shock.
  Meyer NJ, Ferguson JF, Feng R, Wang F, Patel PN, Li M, Xue C, Qu L, Liu Y, Boyd JH, Russell JA, Christie JD, Walley KR, Reilly MP
  (2014) Am J Respir Crit Care Med 190: 656-64
• A heart-adipose tissue connection in the regulation of energy metabolism.
  Collins S
  (2014) Nat Rev Endocrinol 10: 157-63
• Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function.
  Muraoka RS, Lenferink AE, Simpson J, Brantley DM, Roebuck LR, Yakes FM, Arteaga CL
  (2001) J Cell Biol 153: 917-32
• Interrogation of nonconserved human adipose lincRNAs identifies a regulatory role of in adipocyte metabolism.
  Zhang X, Xue C, Lin J, Ferguson JF, Weiner A, Liu W, Han Y, Hinkle C, Li W, Jiang H, Gosai S, Hachet M, Garcia BA, Gregory BD, Soccio RE, Hogenesch JB, Seale P, Li M, Reilly MP
  (2018) Sci Transl Med 10:
• Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling.
  Boucher J, Mori MA, Lee KY, Smyth G, Liew CW, Macotela Y, Rourk M, Bluher M, Russell SJ, Kahn CR
  (2012) Nat Commun 3: 902
• HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning.
  Ferrari A, Longo R, Fiorino E, Silva R, Mitro N, Cermenati G, Gilardi F, Desvergne B, Andolfo A, Magagnotti C, Caruso D, Fabiani E, Hiebert SW, Crestani M
  (2017) Nat Commun 8: 93