Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Talchai C, Xuan S, Kitamura T, DePinho RA, Accili D (2012) Nat Genet 44: 406-12, S1 Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Delong T, Wiles TA, Baker RL, Bradley B, Barbour G, Reisdorph R, Armstrong M, Powell RL, Reisdorph N, Kumar N, Elso CM, DeNicola M, Bottino R, Powers AC, Harlan DM, Kent SC, Mannering SI, Haskins K (2016) Science 351: 711-4 Insulin is required for the liver to respond to intraportal glucose delivery in the conscious dog. Pagliassotti MJ, Moore MC, Neal DW, Cherrington AD (1992) Diabetes 41: 1247-56 Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. Hayes MG, Urbanek M, Hivert MF, Armstrong LL, Morrison J, Guo C, Lowe LP, Scheftner DA, Pluzhnikov A, Levine DM, McHugh CP, Ackerman CM, Bouchard L, Brisson D, Layden BT, Mirel D, Doheny KF, Leya MV, Lown-Hecht RN, Dyer AR, Metzger BE, Reddy TE, Cox NJ, Lowe WL, HAPO Study Cooperative Research Group (2013) Diabetes 62: 3282-91 Glucose metabolism in vivo in four commonly used inbred mouse strains. Berglund ED, Li CY, Poffenberger G, Ayala JE, Fueger PT, Willis SE, Jewell MM, Powers AC, Wasserman DH (2008) Diabetes 57: 1790-9 Human proinsulin-specific antigenic determinants identified by monoclonal antibodies. Madsen OD, Frank BH, Steiner DF (1984) Diabetes 33: 1012-6 A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. Paterson AD, Waggott D, Boright AP, Hosseini SM, Shen E, Sylvestre MP, Wong I, Bharaj B, Cleary PA, Lachin JM, MAGIC (Meta-Analyses of Glucose and Insulin-related traits Consortium), Below JE, Nicolae D, Cox NJ, Canty AJ, Sun L, Bull SB, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group (2010) Diabetes 59: 539-49 The development and utility of a novel scale that quantifies the glycemic progression toward type 1 diabetes over 6 months. Sosenko JM, Skyler JS, Beam CA, Boulware D, Mahon JL, Krischer JP, Greenbaum CJ, Rafkin LE, Matheson D, Herold KC, Palmer JP, Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups (2015) Diabetes Care 38: 940-2 A new approach for diagnosing type 1 diabetes in autoantibody-positive individuals based on prediction and natural history. Sosenko JM, Skyler JS, DiMeglio LA, Beam CA, Krischer JP, Greenbaum CJ, Boulware D, Rafkin LE, Matheson D, Herold KC, Mahon J, Palmer JP, Type 1 Diabetes TrialNet Study Group, Diabetes Prevention Trial-Type 1 Study Group (2015) Diabetes Care 38: 271-6 Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment. Orban T, Bundy B, Becker DJ, Dimeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Marks JB, Monzavi R, Moran A, Peakman M, Raskin P, Russell WE, Schatz D, Wherrett DK, Wilson DM, Krischer JP, Skyler JS, Type 1 Diabetes TrialNet Abatacept Study Group (2014) Diabetes Care 37: 1069-75 Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA in New-Onset Type 1 Diabetes. Haller MJ, Schatz DA, Skyler JS, Krischer JP, Bundy BN, Miller JL, Atkinson MA, Becker DJ, Baidal D, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Herold KC, Marks JB, Moran A, Rodriguez H, Russell W, Wilson DM, Greenbaum CJ, Type 1 Diabetes TrialNet ATG-GCSF Study Group (2018) Diabetes Care 41: 1917-1925 The direct and indirect effects of insulin on hepatic glucose production in vivo. Cherrington AD, Edgerton D, Sindelar DK (1998) Diabetologia 41: 987-96 Immature transformed rat islet beta-cells differentially express C-peptides derived from the genes coding for insulin I and II as well as a transfected human insulin gene. Blume N, Petersen JS, Andersen LC, Kofod H, Dyrberg T, Michelsen BK, Serup P, Madsen OD (1992) Mol Endocrinol 6: 299-307 The production and characterization of monoclonal antibodies specific for human proinsulin using a sensitive microdot assay procedure. Madsen OD, Cohen RM, Fitch FW, Rubenstein AH, Steiner DF (1983) Endocrinology 113: 2135-44 The NC2 domain of collagen IX provides chain selection and heterotrimerization. Boudko SP, Zientek KD, Vance J, Hacker JL, Engel J, Bächinger HP (2010) J Biol Chem 285: 23721-31 Population-based, case-control study of blood C-peptide level and breast cancer risk. Yang G, Lu G, Jin F, Dai Q, Best R, Shu XO, Chen JR, Pan XY, Shrubsole M, Zheng W (2001) Cancer Epidemiol Biomarkers Prev 10: 1207-11 Effect of portal glucose sensing on incretin hormone secretion in a canine model. Edgerton DS, Kraft G, Smith MS, Moore LM, Farmer B, Scott M, Moore MC, Nauck MA, Cherrington AD (2019) Am J Physiol Endocrinol Metab 317: E244-E249 Chronic overeating impairs hepatic glucose uptake and disposition. Coate KC, Kraft G, Shiota M, Smith MS, Farmer B, Neal DW, Williams P, Cherrington AD, Moore MC (2015) Am J Physiol Endocrinol Metab 308: E860-7 Pretransplantation C-Peptide level predicts early posttransplantation diabetes mellitus and has an impact on survival after allogeneic stem cell transplantation. Griffith ML, Jagasia MH, Misfeldt AA, Chen H, Engelhardt BG, Kassim A, Savani BN, Survant M, Jagasia SM (2011) Biol Blood Marrow Transplant 17: 86-92 A novel glucagon receptor antagonist, NNC 25-0926, blunts hepatic glucose production in the conscious dog. Rivera N, Everett-Grueter CA, Edgerton DS, Rodewald T, Neal DW, Nishimura E, Larsen MO, Jacobsen LO, Kristensen K, Brand CL, Cherrington AD (2007) J Pharmacol Exp Ther 321: 743-52 Inhalation of human insulin is associated with improved insulin action compared with subcutaneous injection and endogenous secretion in dogs. Edgerton DS, Stettler KM, Neal DW, Scott M, Bowen L, Wilson W, Hobbs CH, Leach C, Strack TR, Cherrington AD (2006) J Pharmacol Exp Ther 319: 1258-64 The SDF-1α/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells. Kayali AG, Lopez AD, Hao E, Hinton A, Hayek A, King CC (2012) PLoS One 7: e38721 The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy. Urbanek M, Hayes MG, Lee H, Freathy RM, Lowe LP, Ackerman C, Jafari N, Dyer AR, Cox NJ, Dunger DB, Hattersley AT, Metzger BE, Lowe WL (2012) PLoS One 7: e32958 Effects of pharmacologic hyperglucagonemia on plasma amino acid concentrations in normal and diabetic man. Liljenquist JE, Lewis SB, Cherrington AD, Sinclair-Smith BC, Lacy WW (1981) Metabolism 30: 1195-9 A fall in portal vein insulin does not cause the alpha-cell response to mild, non-insulin-induced hypoglycemia in conscious dogs. Gustavson SM, Nishizawa M, Farmer B, Neal D, Brissova M, Powers AC, Cherrington AD (2003) Metabolism 52: 1418-25 Counterregulatory responses to hypoglycemia differ between glimepiride and glyburide in non diabetic individuals. Joy NG, Tate DB, Davis SN (2015) Metabolism 64: 729-37 Association between prostate-specific antigen and leptin, adiponectin, HbA1c or C-peptide among African-American and Caucasian men. Fowke JH, Matthews CM, Buchowski MS, Signorello LB, Chang SS, Cookson MS, Blot WJ (2008) Prostate Cancer Prostatic Dis 11: 264-9 Exaggerated epinephrine response to hypoglycemia in a physically fit, well-controlled IDDM subject. Davis SN, Goldstein RE, Cherrington AD, Price L (1994) Diabetes Res Clin Pract 22: 139-46
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