Keyword Connections

•  Brian Christman
•  Julie Bastarache

•  Lorraine Ware
•  Ryan Stark

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Publications

• The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group.
  Bernard GR, Wheeler AP, Russell JA, Schein R, Summer WR, Steinberg KP, Fulkerson WJ, Wright PE, Christman BW, Dupont WD, Higgins SB, Swindell BB
  (1997) N Engl J Med 336: 912-8
• Treating patients with severe sepsis.
  Wheeler AP, Bernard GR
  (1999) N Engl J Med 340: 207-14
• Immunology. Getting sepsis therapy right.
  Hotchkiss RS, Sherwood ER
  (2015) Science 347: 1201-2
• Defining sepsis.
  Knaus WA, Harrell FE, Wagner DP
  (1994) JAMA 272: 1901
• Automated identification of postoperative complications within an electronic medical record using natural language processing.
  Murff HJ, FitzHenry F, Matheny ME, Gentry N, Kotter KL, Crimin K, Dittus RS, Rosen AK, Elkin PL, Brown SH, Speroff T
  (2011) JAMA 306: 848-55
• Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury.
  Rice TW, Wheeler AP, Thompson BT, deBoisblanc BP, Steingrub J, Rock P, NIH NHLBI Acute Respiratory Distress Syndrome Network of Investigators, NHLBI ARDS Clinical Trials Network
  (2011) JAMA 306: 1574-81
• Monitoring the inflammatory response to infection through the integration of MALDI IMS and MRI.
  Attia AS, Schroeder KA, Seeley EH, Wilson KJ, Hammer ND, Colvin DC, Manier ML, Nicklay JJ, Rose KL, Gore JC, Caprioli RM, Skaar EP
  (2012) Cell Host Microbe 11: 664-73
• A Two-Biomarker Model Predicts Mortality in the Critically Ill with Sepsis.
  Mikacenic C, Price BL, Harju-Baker S, O'Mahony DS, Robinson-Cohen C, Radella F, Hahn WO, Katz R, Christiani DC, Himmelfarb J, Liles WC, Wurfel MM
  (2017) Am J Respir Crit Care Med 196: 1004-1011
• Beta 2 microglobulin knockout mice are resistant to lethal intraabdominal sepsis.
  Sherwood ER, Lin CY, Tao W, Hartmann CA, Dujon JE, French AJ, Varma TK
  (2003) Am J Respir Crit Care Med 167: 1641-9
• Sepsis in cirrhosis: report on the 7th meeting of the International Ascites Club.
  Wong F, Bernardi M, Balk R, Christman B, Moreau R, Garcia-Tsao G, Patch D, Soriano G, Hoefs J, Navasa M, International Ascites Club
  (2005) Gut 54: 718-25
• Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18.
  Wynn JL, Wilson CS, Hawiger J, Scumpia PO, Marshall AF, Liu JH, Zharkikh I, Wong HR, Lahni P, Benjamin JT, Plosa EJ, Weitkamp JH, Sherwood ER, Moldawer LL, Ungaro R, Baker HV, Lopez MC, McElroy SJ, Colliou N, Mohamadzadeh M, Moore DJ
  (2016) Proc Natl Acad Sci U S A 113: E2627-35
• The immunopathogenesis of sepsis in elderly patients.
  Opal SM, Girard TD, Ely EW
  (2005) Clin Infect Dis 41 Suppl 7: S504-12
• Drotrecogin alfa (activated) treatment of older patients with severe sepsis.
  Ely EW, Angus DC, Williams MD, Bates B, Qualy R, Bernard GR
  (2003) Clin Infect Dis 37: 187-95
• Insights into severe sepsis in older patients: from epidemiology to evidence-based management.
  Girard TD, Opal SM, Ely EW
  (2005) Clin Infect Dis 40: 719-27
• Very late-onset group B Streptococcus meningitis, sepsis, and systemic shigellosis due to interleukin-1 receptor-associated kinase-4 deficiency.
  Krause JC, Ghandil P, Chrabieh M, Casanova JL, Picard C, Puel A, Creech CB
  (2009) Clin Infect Dis 49: 1393-6
• Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis.
  Tucker EI, Verbout NG, Leung PY, Hurst S, McCarty OJ, Gailani D, Gruber A
  (2012) Blood 119: 4762-8
• Proinflammatory cytokines and hemofiltration membranes.
  Goldfarb S, Golper TA
  (1994) J Am Soc Nephrol 5: 228-32
• Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans.
  Ferguson JF, Meyer NJ, Qu L, Xue C, Liu Y, DerOhannessian SL, Rushefski M, Paschos GK, Tang S, Schadt EE, Li M, Christie JD, Reilly MP
  (2015) Hum Mol Genet 24: 1801-12
• The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors: the VISIONS cohort magnetic resonance imaging study*.
  Gunther ML, Morandi A, Krauskopf E, Pandharipande P, Girard TD, Jackson JC, Thompson J, Shintani AK, Geevarghese S, Miller RR, Canonico A, Merkle K, Cannistraci CJ, Rogers BP, Gatenby JC, Heckers S, Gore JC, Hopkins RO, Ely EW, VISIONS Investigation, VISualizing Icu SurvivOrs Neuroradiological Sequelae
  (2012) Crit Care Med 40: 2022-32
• Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial.
  Janz DR, Bastarache JA, Rice TW, Bernard GR, Warren MA, Wickersham N, Sills G, Oates JA, Roberts LJ, Ware LB, Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis Study Group
  (2015) Crit Care Med 43: 534-41
• Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome.
  Calfee CS, Matthay MA, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB
  (2015) Crit Care Med 43: 1790-7
• Cecal ligation model of sepsis in mice: new insights.
  Bastarache JA, Matthay MA
  (2013) Crit Care Med 41: 356-7
• Statins and delirium during critical illness: a multicenter, prospective cohort study.
  Morandi A, Hughes CG, Thompson JL, Pandharipande PP, Shintani AK, Vasilevskis EE, Han JH, Jackson JC, Laskowitz DT, Bernard GR, Ely EW, Girard TD
  (2014) Crit Care Med 42: 1899-909
• Drotrecogin alfa (activated) (recombinant human activated protein C) for the treatment of severe sepsis.
  Bernard GR
  (2003) Crit Care Med 31: S85-93
• Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis.
  Ely EW, Laterre PF, Angus DC, Helterbrand JD, Levy H, Dhainaut JF, Vincent JL, Macias WL, Bernard GR, PROWESS Investigators
  (2003) Crit Care Med 31: 12-9
• Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis.
  Bernard GR, Ely EW, Wright TJ, Fraiz J, Stasek JE, Russell JA, Mayers I, Rosenfeld BA, Morris PE, Yan SB, Helterbrand JD
  (2001) Crit Care Med 29: 2051-9
• Aspirin for Sepsis Prophylaxis: An Ounce of Prevention?
  Casey JD, Semler MW, Bastarache JA
  (2017) Crit Care Med 45: 1959-1960
• A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation.
  Vincent JL, Ramesh MK, Ernest D, LaRosa SP, Pachl J, Aikawa N, Hoste E, Levy H, Hirman J, Levi M, Daga M, Kutsogiannis DJ, Crowther M, Bernard GR, Devriendt J, Puigserver JV, Blanzaco DU, Esmon CT, Parrillo JE, Guzzi L, Henderson SJ, Pothirat C, Mehta P, Fareed J, Talwar D, Tsuruta K, Gorelick KJ, Osawa Y, Kaul I
  (2013) Crit Care Med 41: 2069-79
• Association between cell-free hemoglobin, acetaminophen, and mortality in patients with sepsis: an observational study.
  Janz DR, Bastarache JA, Peterson JF, Sills G, Wickersham N, May AK, Roberts LJ, Ware LB
  (2013) Crit Care Med 41: 784-90
• Research in sepsis and acute respiratory distress syndrome: are we changing course?
  Bernard GR
  (1999) Crit Care Med 27: 434-6
• Effects of ibuprofen on the physiology and survival of hypothermic sepsis. Ibuprofen in Sepsis Study Group.
  Arons MM, Wheeler AP, Bernard GR, Christman BW, Russell JA, Schein R, Summer WR, Steinberg KP, Fulkerson W, Wright P, Dupont WD, Swindell BB
  (1999) Crit Care Med 27: 699-707
• Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome.
  O'Neal HR, Koyama T, Koehler EA, Siew E, Curtis BR, Fremont RD, May AK, Bernard GR, Ware LB
  (2011) Crit Care Med 39: 1343-50
• A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis.
  Rice TW, Wheeler AP, Bernard GR, Vincent JL, Angus DC, Aikawa N, Demeyer I, Sainati S, Amlot N, Cao C, Ii M, Matsuda H, Mouri K, Cohen J
  (2010) Crit Care Med 38: 1685-94
• Association between the choice of IV crystalloid and in-hospital mortality among critically ill adults with sepsis*.
  Raghunathan K, Shaw A, Nathanson B, Stürmer T, Brookhart A, Stefan MS, Setoguchi S, Beadles C, Lindenauer PK
  (2014) Crit Care Med 42: 1585-91
• Survival advantage of coagulation factor XI-deficient mice during peritoneal sepsis.
  Tucker EI, Gailani D, Hurst S, Cheng Q, Hanson SR, Gruber A
  (2008) J Infect Dis 198: 271-4
• Degradation products of fibrinogen and fibrin in bacteremia due to gram-negative rods.
  Satterwhite TK, Hawiger J, Burklow SL, Koenig MG
  (1973) J Infect Dis 127: 437-41
• Leukotriene B4 enhances innate immune defense against the puerperal sepsis agent Streptococcus pyogenes.
  Soares EM, Mason KL, Rogers LM, Serezani CH, Faccioli LH, Aronoff DM
  (2013) J Immunol 190: 1614-22
• PPAR-γ/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis.
  Ferreira AE, Sisti F, Sônego F, Wang S, Filgueiras LR, Brandt S, Serezani AP, Du H, Cunha FQ, Alves-Filho JC, Serezani CH
  (2014) J Immunol 192: 2357-65
• Neonatal CD71+ Erythroid Cells Do Not Modify Murine Sepsis Mortality.
  Wynn JL, Scumpia PO, Stocks BT, Romano-Keeler J, Alrifai MW, Liu JH, Kim AS, Alford CE, Matta P, Weitkamp JH, Moore DJ
  (2015) J Immunol 195: 1064-70